TY - JOUR A1 - Papastavrou, Areti A1 - Schmidt, Ina A1 - Deng, Kefu A1 - Steinmann, Paul T1 - On age-dependent bone remodeling JF - Journal of Biomechanics N2 - A number of previous studies have investigated the possibilities of modelling the change in density of bones. Remodeling can be formulated at the constitutive or the kinematic level. In this work we introduce a formulation for the density growth process which takes not only the mechanical stimulus into account but also the influence of age on the evolution of growth. We demonstrate the implementation in the context of the finite element method. This novel approach is illustrated for a simple uniaxial extension test and is verified against previous numerical results. Moreover, two further physiologically motivated examples are performed. The results of the proposed modified model show excellent agreement with comparable results from literature and are promising for the application to real-life problems. KW - bone remodeling KW - density change KW - growth KW - finite element method KW - adaption Y1 - 2020 U6 - https://doi.org/10.1016/j.jbiomech.2020.109701 SN - 1873-2380 IS - 103 PB - Elsevier BV CY - Amsterdam ER - TY - JOUR A1 - Papastavrou, Areti A1 - Schmidt, Ina A1 - Steinmann, Paul T1 - On biological availability dependent bone remodeling JF - Computer Methods in Biomechanics and Biomedical Engineering N2 - Modeling the evolution of bone density is relevant for understanding, simulation and possible prediction of bone response to external and internal influences. In this work we present a formulation for the bone density evolution process that takes into account not only the commonly considered mechanical stimulus, but, as novelty, also the influence of the availability of nutrients and hormones, with its implementation pursued within the finite element method. A simple uni-axial extension test is used to illustrate and compare our novel model against the classical approach. The results of the proposed modified model are promising for application to real-life problems. KW - bone remodeling KW - density change KW - finite element method Y1 - 2020 U6 - https://doi.org/10.1080/10255842.2020.1736050 SN - 1476-8259 VL - 23 (2020) PB - Informa UK Limited ER -