@article{MuellerMaerzSchmolzetal., author = {Mueller, Silke and M{\"a}rz, Reinhard and Schmolz, Manfred and Drewelow, Bernd}, title = {Intraindividual long term stability and response corridors of cytokines in healthy volunteers detected by a standardized whole-blood culture system for bed-side-application}, series = {BMC Medical Research Methodology}, volume = {2012}, journal = {BMC Medical Research Methodology}, publisher = {BioMed Central}, organization = {Institute for Clinical Pharmacology, Medical Faculty, University of RostockUniversit{\"a}tsklinik Rostock}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:92-opus-1014}, abstract = {Up to now, cytokines have been regarded as difficult parameters for the characterisation of the immune system. The study shows that, depending of the type of cytokine, the variability of these potent mediators of immune functions in fact be high high between subjects, but relatively small within a subject. By using appropriate statistical techniques, the use of cytokines as endpoints in investigational clinical studies has become possible.}, subject = {Immunsystem}, language = {en} } @article{SchmolzMaerzSchaudtetal.2014, author = {Schmolz, Manfred and M{\"a}rz, Reinhard and Schaudt, Marco and Schaudt, Cornelia and Lauster, Caroline}, title = {Immunomodulatory Activities of a Concentrated Fruit and Vegetable Juice Tested in a Randomized, Placebo-Controlled, Double-Blind Clinical Trial in Healthy Volunteers}, series = {Food and Nutrition Sciences}, volume = {2014}, journal = {Food and Nutrition Sciences}, number = {5}, organization = {EDI GmbH, Reutlingen}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:92-opus-1255}, pages = {341-350}, year = {2014}, abstract = {A randomized, placebo-controlled trial with healthy volunteers (n = 22) was conducted to investigate the immunomodulatory activities of a concentrated fruit and vegetable juice over a period of 7 weeks. Immune response was characterized with the True-culture (R) whole blood assay. Out of 30 cytokines significant increases (t-test, p< 0,05) were shown for the T-cell dependent cytokines GM-CSF, IFNgamma (p = 0,078), IL-4, IL-10, IL-17 and TNFbeta after 3 days of juice intake. The study confirmed former results of stable levels of cytokines over several weeks within the individual, while the variabilty between individuals can be high. Studies must be designed analyzed carefully to be able to characterize immune responses properly.}, subject = {Klinisches Experiment}, language = {en} }