@article{RichterZimniTomovaetal.2021, author = {Richter, Kneginja and Zimni, Melanie and Tomova, Iva and Retzer, Lukas and H{\"o}fig, Joachim and Kellner, Stefanie and Fries, Carla and Bernstein, Karina and Hitzl, Wolfgang and Hillemacher, Thomas and Miloseva, Lence and Acker, Jens}, title = {Insomnia Associated with Tinnitus and Gender Differences}, series = {International Journal of Environmental Research and Public Health}, volume = {18}, journal = {International Journal of Environmental Research and Public Health}, number = {6}, publisher = {MDPI AG}, issn = {1660-4601}, doi = {10.3390/ijerph18063209}, pages = {10}, year = {2021}, abstract = {Chronic tinnitus causes a decrease in well-being and can negatively affect sleep quality. It has further been indicated that there are clinically relevant gender differences, which may also have an impact on sleep quality. By conducting a retrospective and explorative data analysis for differences in patients with tinnitus and patients diagnosed with tinnitus and insomnia, hypothesized differences were explored in the summed test scores and on item-level of the validated psychometric instruments. A cross-sectional study was conducted collecting data from a sample of tinnitus patients (n = 76). Insomnia was diagnosed in 49 patients. Gender differences were found on aggregated test scores of the MADRS and BDI with men scoring higher than women, indicating higher depressive symptoms in men. Women stated to suffer more from headaches (p \< 0.003), neck pain (p \< 0.006) and nervousness as well as restlessness (p \< 0.02). Women also reported an increase in tinnitus loudness in response to stress compared to men (p \< 0.03). Male individuals with tinnitus and insomnia have higher depression scores and more clinically relevant depressive symptoms than women, who suffer more from psychosomatic symptoms. The results indicate a need for a targeted therapy of depressive symptoms in male patients and targeted treatment of psychosomatic symptoms, stress-related worsening of insomnia and tinnitus in women.}, language = {en} } @article{RichterKellnerHillemacheretal.2021, author = {Richter, Kneginja and Kellner, Stefanie and Hillemacher, Thomas and Golubnitschaja, Olga}, title = {Sleep quality and COVID-19 outcomes: the evidence-based lessons in the framework of predictive, preventive and personalised (3P) medicine}, series = {EPMA Journal}, volume = {12}, journal = {EPMA Journal}, number = {2}, publisher = {Springer Science and Business Media LLC}, issn = {1878-5077}, doi = {10.1007/s13167-021-00245-2}, pages = {221 -- 241}, year = {2021}, abstract = {Sleep quality and duration play a pivotal role in maintaining physical and mental health. In turn, sleep shortage, deprivation and disorders are per evidence the risk factors and facilitators of a broad spectrum of disorders, amongst others including depression, stroke, chronic inflammation, cancers, immune defence insufficiency and individual predisposition to infection diseases with poor outcomes, for example, related to the COVID-19 pandemic. Keeping in mind that COVID-19-related global infection distribution is neither the first nor the last pandemic severely affecting societies around the globe to the costs of human lives accompanied with enormous economic burden, lessons by predictive, preventive and personalised (3P) medical approach are essential to learn and to follow being better prepared to defend against global pandemics. To this end, under extreme conditions such as the current COVID-19 pandemic, the reciprocal interrelationship between the sleep quality and individual outcomes becomes evident, namely, at the levels of disease predisposition, severe versus mild disease progression, development of disease complications, poor outcomes and related mortality for both - population and healthcare givers. The latter is the prominent example clearly demonstrating the causality of severe outcomes, when the long-lasting work overload and shift work rhythm evidently lead to the sleep shortage and/or deprivation that in turn causes immune response insufficiency and strong predisposition to the acute infection with complications. This article highlights and provides an in-depth analysis of the concerted risk factors related to the sleep disturbances under the COVID-19 pandemic followed by the evidence-based recommendations in the framework of predictive, preventive and personalised medical approach.}, language = {en} } @article{LichtAltFuchsetal.2021, author = {Licht, Christiane and Alt, Eva and Fuchs, Sarah and Ruttmann, Axel and Richter, Kneginja and Hillemacher, Thomas}, title = {Repetitive transcranial magnetic stimulation (rTMS) for catatonia}, series = {Brain Stimulation}, volume = {14}, journal = {Brain Stimulation}, number = {6}, publisher = {Elsevier BV}, issn = {1935-861X}, doi = {10.1016/j.brs.2021.10.154}, year = {2021}, language = {en} }