@unpublished{MuellerMaerzSchmolzetal.2012, author = {M{\"u}ller, Silke and M{\"a}rz, Reinhard and Schmolz, Manfred and Drewelow, Bernd and Eschmann, Klaus and Meiser, Peter}, title = {Placebo-controlled randomized clinical trial on the immunomodulating activities of low- and high-dose bromelain after oral administration - new evidence on the antiinflammatory mode of action of bromelain}, organization = {Instiute of Clinical Pharmacology, Medical Faculty, University of Rostock}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:92-opus-1022}, year = {2012}, abstract = {In a randomized controlled multiple cross-over trial, the effect of a single application of 1000 and 3000 F.I.P. bromelain on 6 cytokines, of male healthy volunteers was studied. The analysis of cytokines (Interferon gamma, IL-2, IL-6, IL8, IL-10, IL13 and MCP-1) was performed with the TrueCulture(tm) whole-blood culture system (EDI GmbH). With a single dose of 3000 F. I. P. bromelain, IFNgamma was found to be significantly stimulated in the afternoon hours compared to placebo (p = 0.043; Mixed Linear Model, Bonferroni adjusted).}, language = {en} }