@article{MuellerMaerzSchmolzetal., author = {Mueller, Silke and M{\"a}rz, Reinhard and Schmolz, Manfred and Drewelow, Bernd}, title = {Intraindividual long term stability and response corridors of cytokines in healthy volunteers detected by a standardized whole-blood culture system for bed-side-application}, series = {BMC Medical Research Methodology}, volume = {2012}, journal = {BMC Medical Research Methodology}, publisher = {BioMed Central}, organization = {Institute for Clinical Pharmacology, Medical Faculty, University of RostockUniversit{\"a}tsklinik Rostock}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:92-opus-1014}, abstract = {Up to now, cytokines have been regarded as difficult parameters for the characterisation of the immune system. The study shows that, depending of the type of cytokine, the variability of these potent mediators of immune functions in fact be high high between subjects, but relatively small within a subject. By using appropriate statistical techniques, the use of cytokines as endpoints in investigational clinical studies has become possible.}, subject = {Immunsystem}, language = {en} }