TY - JOUR A1 - Schmolz, Manfred A1 - März, Reinhard A1 - Schaudt, Marco A1 - Schaudt, Cornelia A1 - Lauster, Caroline T1 - Immunomodulatory Activities of a Concentrated Fruit and Vegetable Juice Tested in a Randomized, Placebo-Controlled, Double-Blind Clinical Trial in Healthy Volunteers T2 - Food and Nutrition Sciences N2 - A randomized, placebo-controlled trial with healthy volunteers (n = 22) was conducted to investigate the immunomodulatory activities of a concentrated fruit and vegetable juice over a period of 7 weeks. Immune response was characterized with the True-culture (R) whole blood assay. Out of 30 cytokines significant increases (t-test, p< 0,05) were shown for the T-cell dependent cytokines GM-CSF, IFNgamma (p = 0,078), IL-4, IL-10, IL-17 and TNFbeta after 3 days of juice intake. The study confirmed former results of stable levels of cytokines over several weeks within the individual, while the variabilty between individuals can be high. Studies must be designed analyzed carefully to be able to characterize immune responses properly. KW - Klinisches Experiment KW - Cytokine KW - Saft KW - Randomized Placebo-Controlled Clinical Trial KW - Ex Vivo KW - Cytokine KW - Juice Concentrate Y1 - 2014 UR - https://opus4.kobv.de/opus4-ohm/frontdoor/index/index/docId/8 UR - https://nbn-resolving.org/urn:nbn:de:bvb:92-opus-1255 VL - 2014 IS - 5 ER -