TY - INPR A1 - Müller, Silke A1 - März, Reinhard A1 - Schmolz, Manfred A1 - Drewelow, Bernd A1 - Eschmann, Klaus A1 - Meiser, Peter T1 - Placebo-controlled randomized clinical trial on the immunomodulating activities of low- and high-dose bromelain after oral administration - new evidence on the antiinflammatory mode of action of bromelain N2 - In a randomized controlled multiple cross-over trial, the effect of a single application of 1000 and 3000 F.I.P. bromelain on 6 cytokines, of male healthy volunteers was studied. The analysis of cytokines (Interferon gamma, IL-2, IL-6, IL8, IL-10, IL13 and MCP-1) was performed with the TrueCulture(tm) whole-blood culture system (EDI GmbH). With a single dose of 3000 F. I. P. bromelain, IFNgamma was found to be significantly stimulated in the afternoon hours compared to placebo (p = 0.043; Mixed Linear Model, Bonferroni adjusted). N2 - In einer randomisierten, controlleirten Cross-Over-Studie wurde der Effekt einer einmaligen Appliaktion von 1000 bzw. 3000 F. I. P. Bromelain (Ursapharm GmbH, Saarbrücken)untersucht. Endpunkte waren 6 Zytokine(Interferon gamma, IL-2, IL-6, IL8, IL-10, IL13 and MCP-1), die mittels TrueCulture-Test-System (EDI-GmbH, Reutlingen) analysiert wurden. Die Analyse mittels Gemischtem Linearen Model ergab, dass die Doseriung von 3000 F.I.P. Bromelain einen signifikanten Anstieg im Vergleich zu Plazebo bewirkte (p=0,043, Bonferroni-korrigiert). KW - Immune System KW - bromelain KW - cytokines KW - antiinflammatory activity KW - circadian rhythm Y1 - 2013 UR - https://opus4.kobv.de/opus4-ohm/frontdoor/index/index/docId/52 UR - https://nbn-resolving.org/urn:nbn:de:bvb:92-opus-1022 N1 - Originalversion zu finden in: Phytotherpy Research. 27(2013)2, S.199-204 http://onlinelibrary.wiley.com/doi/10.1002/ptr.4678/abstract ER -