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A New Approach to Flux Coupling Analysis of Metabolic Networks

Please always quote using this URN:urn:nbn:de:0296-matheon-3501
  • Flux coupling analysis is a method to identify blocked and coupled reactions in a metabolic network at steady state. We present a new approach to flux coupling analysis, which uses a minimum set of generators of the steady state flux cone. Our method does not require to reconfigure the network by splitting reversible reactions into forward and backward reactions. By distinguishing different types of reactions (irreversible, pseudo-irreversible, fully reversible), we show that reaction coupling relationships can only hold between certain reaction types. Based on this mathematical analysis, we propose a new algorithm for flux coupling analysis.

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Metadaten
Author:Abdelhalim Larhlimi, Alexander Bockmayr
URN:urn:nbn:de:0296-matheon-3501
Referee:Günter M. Ziegler
Document Type:Preprint, Research Center Matheon
Language:English
Date of first Publication:2006/07/19
Release Date:2006/07/17
Institute:Freie Universität Berlin
Preprint Number:338
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