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SQP Methods for Parameter Identi cation Problems arising in Hyperthermia

Please always quote using this URN:urn:nbn:de:0296-matheon-2418
  • The paper introduces an identification problem arising in modern regional hyperthermia, a cancer therapy aiming at heating the tumor by microwave radiation. The task is to identify the highly individual perfusion, which affects the resulting temperature distribution, from MR measurements. The identification problem is formulated as an optimization problem. Existence of a solution and optimality conditions are analyzed. Different regularizations and problem variants are considered. For the numerical solution, a standard SQP method is used. Sufficient conditions for the convergence of the method are derived. Finally, numerical examples on artificial as well as clinical data are presented.

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Metadaten
Author:Tobias Gänzler, Stefan Volkwein, Martin Weiser
URN:urn:nbn:de:0296-matheon-2418
Referee:Fredi Tröltzsch
Document Type:Preprint, Research Center Matheon
Language:English
Date of first Publication:2005/04/14
Release Date:2005/03/24
Institute:Technische Universität Berlin
Zuse Institute Berlin (ZIB)
Preprint Number:237
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