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A Lattice-Theoretic Framework for Metabolic Pathway Analysis

Please always quote using this URN:urn:nbn:de:0296-matheon-12067
  • Constraint-based analysis of metabolic networks has become a widely used approach in computational systems biology. In the simplest form, a metabolic network is represented by a stoichiometric matrix and thermodynamic information on the irreversibility of certain reactions. Then one studies the set of all steady-state flux vectors satisfying these stoichiometric and thermodynamic constraints. We introduce a new lattice-theoretic framework for the computational analysis of metabolic networks, which focuses on the support of the flux vectors, i.e., we consider only the qualitative information whether or not a certain reaction is active, but not its specific flux rate. Our lattice-theoretic view includes classical metabolic pathway analysis as a special case, but turns out to be much more flexible and general, with a wide range of possible applications. We show how important concepts from metabolic pathway analysis, such as blocked reactions, flux coupling, or elementary modes, can be generalized to arbitrary lattice-based models. We develop corresponding general algorithms and present a number of computational results.

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Metadaten
Author:Yaron A. B. Goldstein, Alexander Bockmayr
URN:urn:nbn:de:0296-matheon-12067
Referee:Peter Deuflhard
Document Type:Preprint, Research Center Matheon
Language:English
Date of first Publication:2013/04/23
Release Date:2013/04/23
Tag:constraint-based analysis; lattice theory; metabolic networks,
Institute:Research Center Matheon
Freie Universität Berlin
MSC-Classification:92-XX BIOLOGY AND OTHER NATURAL SCIENCES / 92Cxx Physiological, cellular and medical topics / 92C42 Systems biology, networks
Preprint Number:1006
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