TY - GEN A1 - Gänzler, Tobias A1 - Volkwein, Stefan A1 - Weiser, Martin T1 - SQP Methods for Parameter Identi cation Problems arising in Hyperthermia N2 - The paper introduces an identification problem arising in modern regional hyperthermia, a cancer therapy aiming at heating the tumor by microwave radiation. The task is to identify the highly individual perfusion, which affects the resulting temperature distribution, from MR measurements. The identification problem is formulated as an optimization problem. Existence of a solution and optimality conditions are analyzed. Different regularizations and problem variants are considered. For the numerical solution, a standard SQP method is used. Sufficient conditions for the convergence of the method are derived. Finally, numerical examples on artificial as well as clinical data are presented. Y1 - 2005 UR - https://opus4.kobv.de/opus4-matheon/frontdoor/index/index/docId/241 UR - https://nbn-resolving.org/urn:nbn:de:0296-matheon-2418 ER -