TY - GEN A1 - David, Laszlo A1 - Bockmayr, Alexander T1 - Computing elementary flux modes involving a set of target reactions N2 - Elementary flux mode (EM) analysis is an important tool in the constraint-based analysis of genome-scale metabolic networks. Due to the combinatorial complexity of these networks, as well as the advances in the level of detail to which they can be reconstructed, an exhaustive enumeration of all EMs is often not practical. Therefore, in recent years interest has shifted towards searching EMs with specific properties. We present a novel method that allows computing EMs containing a given set of target reactions. This generalizes previous algorithms where the set of target reactions consists of a single reaction. In the one-reaction case, our method compares favorably to the previous approaches. In addition, we present several applications of our algorithm for computing EMs containing two target reactions in genome-scale metabolic networks. KW - constraint-based analysis; metabolic networks; elementary flux modes Y1 - 2013 UR - https://opus4.kobv.de/opus4-matheon/frontdoor/index/index/docId/1262 UR - https://nbn-resolving.org/urn:nbn:de:0296-matheon-12621 ER -