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The world has already warmed by more than 1.2C compared with preindustrial levels, resulting in profound, immediate, and rapidly worsening health effects, and moving dangerously close to the agreed limit of maintaining temperatures “well below 2C”. These health impacts are seen on every continent, with the ongoing spread of dengue virus across South America, the cardiovascular and respiratory effects of record heatwaves and wildfires in Australia, western North America, and western Europe, and the undernutrition and mental health effects of floods and droughts in China, Bangladesh, Ethiopia, and South Africa. In the long term, climate change threatens the very foundations of human health and wellbeing, with the Global Risks Report registering climate change as one of the five most damaging or probable global risks every year for the past decade.