Bronze - frei zugänglich aber ohne Lizenzhinweis, d.h. keine Weitergabe
Refine
Year of publication
Document Type
- Conference Proceeding (24)
- Article (21)
- Workingpaper / Report (11)
- Master's Thesis (3)
- Part of a Book (2)
- Bachelor Thesis (1)
- Doctoral Thesis (1)
Language
- English (63) (remove)
Keywords
- Deutschland (2)
- FHD (2)
- Fremdvergleichsgrundsatz (2)
- Germany (2)
- Gewinnverlagerung (2)
- Mixed Reality (2)
- Unternehmensbesteuerung (2)
- corporate income tax (2)
- fairness (2)
- profit-shifting (2)
Department/institution
- Fachbereich - Medien (23)
- Fachbereich - Maschinenbau und Verfahrenstechnik (22)
- Fachbereich - Sozial- & Kulturwissenschaften (6)
- Fachbereich - Elektro- & Informationstechnik (5)
- Creative Media Production and Entertainment Computing (3)
- Fachbereich - Wirtschaftswissenschaften (3)
- Fachbereich - Architektur (2)
- Sound and Vibration Engineering (2)
- Digitale Vernetzung und Informationssicherheit (1)
- Hochschulbibliothek (1)
Men afflicted with hypogonadism have reduced fat-free mass and in some cases a loss in muscle strength. We hypothesize that muscle elasticity of the lower extremities differs between patients with hypogonadism and healthy controls. The shear modulus of the soleus muscle was measured non-invasively using MR elastography (MRE) at 0%, 5%, 10%, 15%, and 20% of the subject’s maximum applied force. The results from this study showed statistical differences between the patients and controls, even though there were no statistical differences in applied force.
Men afflicted with chronic obstructive pulmonary disease (COPD) show signs of muscle dysfunction, such as increased muscle fatigue and acidosis during exercise. We hypothesize that muscle elasticity of the lower extremities differs between patients with COPD and age-related controls. The shear modulus of the soleus muscle was measured non-invasively using MR elastography (MRE) at 0%, 5%, 10%, 15%, and 20% of the subject’s maximum applied force. The results from this study showed statistical differences between the patients and controls, even though there were no statistical differences in the maximum applied force.
Eye tracking is a measurement technique for determining the orientation and viewing direction of an individual’s eyes. It allows for an evaluation of the individual’s gaze and other related information.There is a wide variety of application areas for eye tracking, however the usage in engineeringindustry is still limited. This paper presents a case study for the use of eye tracking in a testingstation for electrical circuit breakers. The case study aims to evaluate the measurement and analysispossible with the Tobii wearable eye tracking system. From the case study, possibilities, limitationsand considerations for eye tracking in industrial settings are identified and discussed. The paperconcludes that while eye tracking can be used to effectively capture and visualize insightfulinformation, it faces major challenges related to subjectivity in analysis and labour intensiveness.
Abstract The modulation-transfer function (MTF) is a fundamental optical metric to measure the optical quality of an imaging system. In the automotive industry it is used to qualify camera systems for ADAS/AD. Each modern ADAS/AD system includes evaluation algorithms for environment perception and decision making that are based on AI/ML methods and neural networks. The performance of these AI algorithms is measured by established metrics like Average Precision (AP) or precision-recall-curves. In this article we research the robustness of the link between the optical quality metric and the AI performance metric. A series of numerical experiments were performed with object detection and instance segmentation algorithms (cars, pedestrians) evaluated on image databases with varying optical quality. We demonstrate with these that for strong optical aberrations a distinct performance loss is apparent, but that for subtle optical quality differences – as might arise during production tolerances – this link does not exhibit a satisfactory correlation. This calls into question how reliable the current industry practice is where a produced camera is tested end-of-line (EOL) with the MTF, and fixed MTF thresholds are used to qualify the performance of the camera-under-test.
Performance Testing and Optimization of Solar Assisted Heating Systems for Multi Family Houses
(2016)
Market and simulation analysis of PVT applications for the determination of new PVT test procedures
(2014)
Many different cell types are able to migrate by formation of a thin actin-based cytoskeletal extension. Recently, it became evident that this extension consists of two distinct substructures, designated lamellipodium and lamellum, which differ significantly in their kinetic and kinematic properties as well as their biochemical composition. We developed a stochastic two-dimensional computer simulation that includes chemical reaction kinetics, G-actin diffusion, and filament transport to investigate the formation of growing actin networks in migrating cells. Model parameters were chosen based on experimental data or theoretical considerations. In this work, we demonstrate the system's ability to form two distinct networks by self-organization. We found a characteristic transition in mean filament length as well as a distinct maximum in depolymerization flux, both within the first 1-2 microm. The separation into two distinct substructures was found to be extremely robust with respect to initial conditions and variation of model parameters. We quantitatively investigated the complex interplay between ADF/cofilin and tropomyosin and propose a plausible mechanism that leads to spatial separation of, respectively, ADF/cofilin- or tropomyosin-dominated compartments. Tropomyosin was found to play an important role in stabilizing the lamellar actin network. Furthermore, the influence of filament severing and annealing on the network properties is explored, and simulation data are compared to existing experimental data.
The rock material pentlandite with the composition Fe4.5Ni4.5S8 was synthesized via high temperature synthesis from the elements. The structure and composition of the material was characterized via powder X-ray diffraction (PXRD), Mössbauer spectroscopy (MB), scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and energy dispersive X-ray spectroscopy (EDX). Two preparation methods of pentlandite bulk electrodes are presented. In the first approach a piece of synthetic pentlandite rock is directly contacted via a wire ferrule. The second approach utilizes pentlandite pellets, pressed from finely ground powder, which is immobilized in a Teflon casing. Both electrodes, whilst being prepared by an additive-free method, reveal high durability during electrocatalytic conversions in comparison to common drop-coating methods. We herein showcase the striking performance of such electrodes to accomplish the hydrogen evolution reaction (HER) and present a standardized method to evaluate the electrocatalytic performance by electrochemical and gas chromatographic methods. Furthermore, we report stability tests via potentiostatic methods at an overpotential of 0.6 V to explore the material limitations of the electrodes during electrolysis under industrial relevant conditions.
In the present contribution, the utilization of steel-mill gases for an industrial methanol synthesis process is described. The focus of this work is on the influence of syngas compositions derived from steel-mill gases on an industrial Cu/ZnO/Al2O3 catalyst. Elevated CO2 and H2O concentrations seem to have an irreversible impact on the activity of the catalyst. In order to obtain realistic gas composition for the catalyst tests, a process simulation of the methanol synthesis was conducted. The calculated gas compositions at the reactor inlet were applied in a practical test in order to evaluate the catalyst stability under steel mill gas conditions. No noticeable deactivation was observed.
The optimization of full-scale biogas plant operation is of great importance to make biomass a competitive source of renewable energy. The implementation of innovative control and optimization algorithms, such as Nonlinear Model Predictive Control, requires an online estimation of operating states of biogas plants. This state estimation allows for optimal control and operating decisions according to the actual state of a plant. In this paper such a state estimator is developed using a calibrated simulation model of a full-scale biogas plant, which is based on the Anaerobic Digestion Model No.1. The use of advanced pattern recognition methods shows that model states can be predicted from basic online measurements such as biogas production, CH4 and CO2 content in the biogas, pH value and substrate feed volume of known substrates. The machine learning methods used are trained and evaluated using synthetic data created with the biogas plant model simulating over a wide range of possible plant operating regions. Results show that the operating state vector of the modelled anaerobic digestion process can be predicted with an overall accuracy of about 90%. This facilitates the application of state-based optimization and control algorithms on full-scale biogas plants and therefore fosters the production of eco-friendly energy from biomass.
We present a system that exploits mobile rotational tracking and photospherical imagery to allow users to share their environment with remotely connected peers “on the go.” We surveyed related interfaces and developed a unique groupware application that shares a mixed reality space with spatially-oriented live video feeds. Users can collaborate through realtime audio, video, and drawings in a virtual space. The developed system was tested in a preliminary user study, which confirmed an increase in spatial and situational awareness among viewers as well as reduction in cognitive workload. Believing that our system provides a novel style of collaboration in mixed reality environments, we discuss future applications and extensions of our prototype.
The methylotrophic yeast Hansenula polymorpha has been established as a highly efficient expression system. Strong promoters derived from the methanol metabolism pathway and mitotically stable high-copy integration have made this organism very effective for heterologous protein expression.
To improve the processing of secretory proteins targeted by the MFα prepro sequence, variations in the amino acid composition near the processing site of Kex2p were investigated (Manuscript I). The insertion of Ala-Pro between MFα prepro sequence and protein of interest leads to an improved processing of the signal sequence in case of interleukin-6 (IL-6) and interferon-α 2a (IFNα-2a). Modeling of the transition sequences confirmed a better exposition of the Kex2p-cleavage site in dependency of Ala-Pro insertions. Analysis of the secreted proteins revealed activity of an Ala-Pro specific endoprotease. Partial removal of the N-terminal Ala-Pro dipeptide was also detected during IFNα-2a processing. The putative protease responsible for the processing of Ala-Pro dipeptides was identified by gene deletion. Significant similarities with Saccharomyces cerevisiae Ste13p were identified.
To generally improve productivity in the H. polymorpha system new fusion protein strategies were investigated (Manuscript II). The recombinantly strongly expressed cytosolic ferritin heavy chain (FTH1) was analyzed with regard to its potential as fusion partner for difficult-to-express target proteins. A fragment of the parathyroid hormone (PTH) was chosen to explore whether fusion to FTH1 enhances PTH stability. We could show that the expression level of this fusion protein was at least of the magnitude of that of FTH1 without fusion partner. The solubility of the fusion protein was increased in comparison to FTH1 alone and no degradation of PTH occurred when fused C-terminally to FTH1.
Ectoine and 5-hydroxyectoine belong to the family of compatible solutes which are known to contribute to the adaptation of the cell to osmotic stress by mediation of a constant turgor. H. polymorpha was engineered to express the enzymes of the H. elongata 5-hydroxyectoine biosynthesis pathway (Manuscript III). Expression of the enzymes EctB, EctA, EctC and EctD in H. polymorpha resulted in production of 5-hydroxyectoine in gram per liter scale with almost full conversion of ectoine to 5-hydroxyectoine. We showed that 5-hydroxyectoine synthesis was influenced by feeding of methanol during cultivation. Furthermore, 5-hydroxyectoine synthesis was downregulated by the addition of methionine, lysine or threonine indicating the existence of a feedback regulated aspartate kinase in H. polymorpha.
This essay looks at the potentials and limitations of user research for studies on the practice of drama education. To date, this field has been dominated by impact studies. After illustrating the blind spots that are created by taking this research approach to the practice of drama education, we will present the user research perspective and look at the opportunities that it provides to generate new, differentiated knowledge. User research makes it possible to illuminate the processes of acquiring and using knowledge in terms of its delivery. It also provides a potential framework of analysis for placing these processes in the delivery context, which includes subjective learning types, relevance and institutional and social conditions. This expanded perspective will make it possible to identify the factors that foster and limit benefits and reflect them in practice.
We report about several experiments on applying mixed reality technology in the context of accessing collective memories from atomic bombs, Holocaust and Second World War. We discuss the impact of Virtual Reality, Augmented Virtuality and Augmented Reality for specific memorial locations. We show how to use a virtual studio for demonstrating an augmented reality application for a specific location in a remote session within a video conference. Augmented Virtuality is used to recreate the local environment, thus providing a context and helping the participants recollect emotions related to a certain place. This technique demonstrates the advantages of using virtual (VR) and augmented (AR) reality environments for rapid prototyping and pitching project ideas in a live remote setting.
“Net Zero-Energy Building” has become a popular catchphrase to describe the synergy between energy-efficient building and renewable energy utilisation to achieve a balanced energy budget over an annual cycle. Taking into account the energy exchange with a grid overcomes the limitations of energy-autonomous buildings with the need for seasonal energy storage on-site. Although the expression, “Net Zero-Energy Building,” appears in many energy policy documents, a harmonised definition or a standardised balancing method is still lacking. This paper reports on the background and the various effects influencing the energy balance approach. After discussing the national energy code framework in Germany, a harmonised terminology and balancing procedure is proposed. The procedure takes not only the energy balance but also energy efficiency and load matching into account.