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Aufgrund der §§ 2 Abs. 4 S. 1, 26 Abs. 3 S. 2 des Gesetzes über die Hochschulen des Landes Nord-rhein-Westfalen (Hochschulgesetz - HG) vom 16.09.2014 (GV. NRW. S. 547) in der aktuell gültigen Fassung und der Grundordnung der Hochschule Düsseldorf vom 08.10.2015 (Verkündungsblatt der Hochschule Düsseldorf, Amtliche Mitteilung Nr. 414) in der aktuell gültigen Fassung hat die Hochschule Düsseldorf die folgende Ordnung als Satzung erlassen.
Die Vierte Satzung zur Änderung der Prüfungsordnung für den gemeinsamen Bachelor-Studiengang Ton und Bild an der Hochschule Düsseldorf und der Robert Schumann Hochschule Düsseldorf vom 12.02.2021 (Verkündungsblatt der Hochschule Düsseldorf, Amtliche Mitteilung Nr. 735; Amts- und Mitteilungsblatt der Robert Schumann Hochschule Düsseldorf Nr. 103) ist wie folgt zu berichtigen: In Anlage 1 wird in dem Projektmodul RSH Modul in den Spalten Credits und Benotung die Angabe „16“ durch die Angabe „20“ ersetzt.
Düsseldorf, den 09.02.2022
819 - Betriebs- und Hygienekonzept für den Präsenzbetrieb der Hochschule Düsseldorf vom 01.02.2022
(2022)
We present a novel metric Spatial Recall Index to assess the performance of machine-learning (ML) algorithms for automotive applications, focusing on where in the image which performance occurs. Typical metrics like intersection-over-union (IoU), precisionrecallcurves or average precision (AP) quantify the performance over a whole database of images, neglecting spatial performance variations. But as the optics of camera systems are spatially variable over the field of view, the performance of ML-based algorithms is also a function of space, which we show in simulation: A realistic objective lens based on a Cooke-triplet that exhibits typical optical aberrations like astigmatism and chromatic aberration, all variable over field, is modeled. The model is then applied to a subset of the BDD100k dataset with spatially-varying kernels. We then quantify local changes in the performance of the pre-trained Mask R-CNN algorithm. Our examples demonstrate the spatial dependence of the performance of ML-based algorithms from the optical quality over field, highlighting the need to take the spatial dimension into account when training ML-based algorithms, especially when looking forward to autonomous driving applications.
Individual addressing of trapped ions and coupling of motional and spin states using RF radiation
(2009)
Individual electrodynamically trapped and laser cooled ions are addressed in frequency space using radio-frequency radiation in the presence of a static magnetic field gradient. In addition, an interaction between motional and spin states induced by an rf field is demonstrated employing rf optical double resonance spectroscopy. These are two essential experimental steps towards realizing a novel concept for implementing quantum simulations and quantum computing with trapped ions.
Vorwort Gender Report
Liebe Leserinnen und Leser,
wie bereits in den vergangenen Jahren haben wir auch in diesem Jahr erneut einen eigenständigen Gender Report als wichtige Ergänzung zum Zahlenspiegel der Hochschule Düsseldorf erstellt, der einen besonderen Fokus auf die Entwicklung und die aktuellen Zahlen der weiblichen Studierenden, Absolventinnen und Beschäftigten legt.
Insbesondere in der jüngsten Vergangenheit ist enorm viel Bewegung in die Debatte rund um das Thema „Gender (und) Diversity“ gekommen – eine wie wir finden äußerst erfreuliche Entwicklung, um immer mehr Menschen für eine offene Diskussion und paritätische Teilhabe zu sensibilisieren. Auch wenn die HSD mit der zielorientierten Umsetzung ihres „gender diversity action plan“ mit gutem Beispiel vorangeht und in der Vergangenheit bereits beachtliche Erfolge in Hinblick auf die Herstellung, Förderung und Wahrung von (Geschlechter-)Gerechtigkeit und verstärkter (Gender)Diversity erreicht hat, sind wir noch nicht am Ziel angelangt.
Vorwort
Liebe Leserinnen und Leser, ich freue mich, Ihnen auch in diesem besonderen Jahr unser statistisches Zahlenwerk vorstellen zu können. Die jüngste Gesamtausgabe – der Zahlenspiegel 2020 – ermöglicht Ihnen detaillierte Einblicke in die Studierenden- und Absolvent*innendaten sowie eine ausführliche Betrachtung der Beschäftigungsverhältnisse und Kennzahlen der Hochschule Düsseldorf.
Zur Abbildung der Zahlen der weiblichen Studierenden, Absolventinnen und Beschäftigten wurde im Rahmen der Umsetzung des „gender diversity action plan“ erneut ein eigenständiger Gender Report erstellt. ...
Aufgrund und im Rahmen der §§ 53-57 des Gesetzes über die Hochschulen des Landes Nordrhein-Westfalen vom 16. September 2014 (GV. NRW. S. 547) zuletzt geändert am 12. Juli 2019 (GV. NRW. S. 377) sowie die Verordnung über die Haushalts- und Wirtschaftsführung der Studierendenschaften der Universitäten, Fachhochschulen und Kunsthochschulen des Landes Nordrhein-Westfalen vom 6. Oktober 2005 (GV. NRW. S. 190) zuletzt geändert am 16. September 2014 (GV. NRW. S. 547) gibt sich die Studierendenschaft der Hochschule Düsseldorf folgende Satzung.
Performance Testing and Optimization of Solar Assisted Heating Systems for Multi Family Houses
(2016)
Market and simulation analysis of PVT applications for the determination of new PVT test procedures
(2014)
In dieser Arbeit werden die definierenden Eigenschaften von Open Educational Resources (OER) recherchiert. Wie können die Anforderungen an Inhalten, Medien-wahl, didaktischen Konzept mit einem hohen Grad an Interaktivität erfüllt werden? – Die Literatur zu diesen Fragestellungen liefert den aktuellen Forschungsstand.
Aufgrund der §§ 2 Abs. 4 S. 1, 26 Abs. 3 S. 2 des Gesetzes über die Hochschulen des Landes Nord-rhein-Westfalen (Hochschulgesetz - HG) vom 16.09.2014 (GV.NRW. S. 547) in der aktuell gültigen Fassung und der Grundordnung der Hochschule Düsseldorf vom 08.10.2015 (Verkündungsblatt der Hochschule Düsseldorf, Amtliche Mitteilung Nr. 414) in der aktuell gültigen Fassung hat der Fachbereichsrat des Fachbereichs Design der Hochschule Düsseldorf die folgende Ordnung als Satzung erlassen.
Aufgrund des § 82a Absatz 1 Satz 1 des Gesetzes über die Hochschulen des Landes Nordrhein-Westfalen (Hochschulgesetz - HG) vom 16.09.2014 (GV. NRW. S. 547) in der aktuell gültigen Fassung in Verbindung mit der Verordnung zur Bewältigung der durch die Coronavirus SARS-CoV-2- Epidemie an den Hochschulbetrieb gestellten Herausforderungen (Corona-Epidemie-Hochschulverordnung) vom 01.12.2021 (GV. NRW. S. 81) in der aktuell gültigen Fassung hat das Präsidium der Hochschule Düsseldorf die folgende Ordnung als Satzung erlassen.
Cell migration is associated with the dynamic protrusion of a thin actin-based cytoskeletal extension at the cell front, which has been shown to consist of two different substructures, the leading lamellipodium and the subsequent lamellum. While the formation of the lamellipodium is increasingly well understood, organizational principles underlying the emergence of the lamellum are just beginning to be unraveled. We report here on a 1D mathematical model which describes the reaction-diffusion processes of a polarized actin network in steady state, and reproduces essential characteristics of the lamellipodium-lamellum system. We observe a steep gradient in filament lengths at the protruding edge, a local depolymerization maximum a few microns behind the edge, as well as a differential dominance of the network destabilizer ADF/cofilin and the stabilizer tropomyosin. We identify simple and robust organizational principles giving rise to the derived network characteristics, uncoupled from the specifics of any molecular implementation, and thus plausibly valid across cell types. An analysis of network length dependence on physico-chemical system parameters implies that to limit array treadmilling to cellular dimensions, network growth has to be truncated by mechanisms other than aging-induced depolymerization, e.g., by myosin-associated network dissociation at the transition to the cell body. Our work contributes to the analytical understanding of the cytoskeletal extension's bisection into lamellipodium and lamellum and sheds light on how cells organize their molecular machinery to achieve motility.
To power dynamic processes in cells, the actin and microtubule cytoskeletons organize into complex structures. Although it is known that cytoskeletal coordination is vital for cell function, the mechanisms by which cross-linking proteins coordinate actin and microtubule activities remain poorly understood. In particular, it is unknown how the distinct mechanical properties of different actin architectures modulate the outcome of actin-microtubule interactions. To address this question, we engineered the protein TipAct, which links growing microtubule ends via end-binding proteins to actin filaments. We show that growing microtubules can be captured and guided by stiff actin bundles, leading to global actin-microtubule alignment. Conversely, growing microtubule ends can transport, stretch and bundle individual actin filaments, thereby globally defining actin filament organization. Our results provide a physical basis to understand actin-microtubule cross-talk, and reveal that a simple cross-linker can enable a mechanical feedback between actin and microtubule organization that is relevant to diverse biological contexts.
Mass spectrometry data is one of the key sources of information in many workflows in medicine and across the life sciences. Mass fragmentation spectra are generally considered to be characteristic signatures of the chemical compound they originate from, yet the chemical structure itself usually cannot be easily deduced from the spectrum. Often, spectral similarity measures are used as a proxy for structural similarity but this approach is strongly limited by a generally poor correlation between both metrics. Here, we propose MS2DeepScore: a novel Siamese neural network to predict the structural similarity between two chemical structures solely based on their MS/MS fragmentation spectra. Using a cleaned dataset of > 100,000 mass spectra of about 15,000 unique known compounds, we trained MS2DeepScore to predict structural similarity scores for spectrum pairs with high accuracy. In addition, sampling different model varieties through Monte-Carlo Dropout is used to further improve the predictions and assess the model's prediction uncertainty. On 3600 spectra of 500 unseen compounds, MS2DeepScore is able to identify highly-reliable structural matches and to predict Tanimoto scores for pairs of molecules based on their fragment spectra with a root mean squared error of about 0.15. Furthermore, the prediction uncertainty estimate can be used to select a subset of predictions with a root mean squared error of about 0.1. Furthermore, we demonstrate that MS2DeepScore outperforms classical spectral similarity measures in retrieving chemically related compound pairs from large mass spectral datasets, thereby illustrating its potential for spectral library matching. Finally, MS2DeepScore can also be used to create chemically meaningful mass spectral embeddings that could be used to cluster large numbers of spectra. Added to the recently introduced unsupervised Spec2Vec metric, we believe that machine learning-supported mass spectral similarity measures have great potential for a range of metabolomics data processing pipelines.
Despite their overwhelming complexity, living cells display a high degree of internal mechanical and functional organization which can largely be attributed to the intracellular biopolymer scaffold, the cytoskeleton. Being a very complex system far from thermodynamic equilibrium, the cytoskeleton's ability to organize is at the same time challenging and fascinating. The extensive amounts of frequently interacting cellular building blocks and their inherent multifunctionality permits highly adaptive behavior and obstructs a purely reductionist approach. Nevertheless (and despite the field's relative novelty), the physics approach has already proved to be extremely successful in revealing very fundamental concepts of cytoskeleton organization and behavior. This review aims at introducing the physics of the cytoskeleton ranging from single biopolymer filaments to multicellular organisms. Throughout this wide range of phenomena, the focus is set on the intertwined nature of the different physical scales (levels of complexity) that give rise to numerous emergent properties by means of self-organization or self-assembly.
Many different cell types are able to migrate by formation of a thin actin-based cytoskeletal extension. Recently, it became evident that this extension consists of two distinct substructures, designated lamellipodium and lamellum, which differ significantly in their kinetic and kinematic properties as well as their biochemical composition. We developed a stochastic two-dimensional computer simulation that includes chemical reaction kinetics, G-actin diffusion, and filament transport to investigate the formation of growing actin networks in migrating cells. Model parameters were chosen based on experimental data or theoretical considerations. In this work, we demonstrate the system's ability to form two distinct networks by self-organization. We found a characteristic transition in mean filament length as well as a distinct maximum in depolymerization flux, both within the first 1-2 microm. The separation into two distinct substructures was found to be extremely robust with respect to initial conditions and variation of model parameters. We quantitatively investigated the complex interplay between ADF/cofilin and tropomyosin and propose a plausible mechanism that leads to spatial separation of, respectively, ADF/cofilin- or tropomyosin-dominated compartments. Tropomyosin was found to play an important role in stabilizing the lamellar actin network. Furthermore, the influence of filament severing and annealing on the network properties is explored, and simulation data are compared to existing experimental data.
Despite its impressive complexity the cytoskeleton succeeds to persistently organize itself and thus the cells' interior. In contrast to classical man-made machines, much of the cellular organization originates from inherent self-assembly and self-organization allowing a high degree of autonomy for various functional units. Recent experimental and theoretical studies revealed numerous examples of cytoskeleton components that arrange and organize in a self-regulative way. In the present review we want to shortly summarize some of the principle mechanisms that are able to inherently trigger and regulate the cytoskeleton organization. Although taken individually most of these regulative principles are rather simple with intuitively predictable consequences, combinations of two or more of these mechanisms can quickly give rise to very complex, unexpected behavior and might even be able to explain the formation of different functional units out of a common pool of available building blocks.
Spec2Vec: Improved mass spectral similarity scoring through learning of structural relationships
(2021)
Spectral similarity is used as a proxy for structural similarity in many tandem mass spectrometry (MS/MS) based metabolomics analyses such as library matching and molecular networking. Although weaknesses in the relationship between spectral similarity scores and the true structural similarities have been described, little development of alternative scores has been undertaken. Here, we introduce Spec2Vec, a novel spectral similarity score inspired by a natural language processing algorithm-Word2Vec. Spec2Vec learns fragmental relationships within a large set of spectral data to derive abstract spectral embeddings that can be used to assess spectral similarities. Using data derived from GNPS MS/MS libraries including spectra for nearly 13,000 unique molecules, we show how Spec2Vec scores correlate better with structural similarity than cosine-based scores. We demonstrate the advantages of Spec2Vec in library matching and molecular networking. Spec2Vec is computationally more scalable allowing structural analogue searches in large databases within seconds.
Actin droplet machine
(2019)
The actin droplet machine is a computer model of a three-dimensional network of actin bundles developed in a droplet of a physiological solution, which implements mappings of sets of binary strings. The actin bundle network is conductive to travelling excitations, i.e. impulses. The machine is interfaced with an arbitrary selected set of k electrodes through which stimuli, binary strings of length k represented by impulses generated on the electrodes, are applied and responses are recorded. The responses are recorded in a form of impulses and then converted to binary strings. The machine's state is a binary string of length k: if there is an impulse recorded on the ith electrode, there is a '1' in the ith position of the string, and '0' otherwise. We present a design of the machine and analyse its state transition graphs. We envisage that actin droplet machines could form an elementary processor of future massive parallel computers made from biopolymers.
Actin filaments are conductive to ionic currents, mechanical and voltage solitons. These travelling localisations can be utilised to generate computing circuits from actin networks. The propagation of localisations on a single actin filament is experimentally unfeasible to control. Therefore, we consider excitation waves propagating on bundles of actin filaments. In computational experiments with a two-dimensional slice of an actin bundle network we show that by using an arbitrary arrangement of electrodes, it is possible to implement two-inputs-one-output circuits.
Als Einführung in die Benutzung der Software SQL Developer Command Line (SQLcl) von Oracle werden folgende Aktionen erklärt: Anmelden, Ausgeben von Tabellen und ihren Metadaten, Verwenden der Befehlshistorie, Formatieren der Ausgabe, Speichern, Bearbeiten und Wiederverwenden von Befehlen sowie das Anlegen von Logdateien. Vorausgesetzt werden geringe Vorkenntnisse von relationalen Datenbankmanagementsystemen mit SQL. Das Video wurde im Rahmen des Projektes EILD.nrw entwickelt, gefördert durch das Ministerium für Kultur und Wissenschaft gemeinsam mit der Digitalen Hochschule NRW (DH.NRW) in der Förderlinie „OERContent.nrw“ (Open Education Resources).
Kohlendioxid, Biomasse und Regenerativer Strom - Ressourcen einer neuen Kohlenstoffwirtschaft?
(2017)
The rock material pentlandite with the composition Fe4.5Ni4.5S8 was synthesized via high temperature synthesis from the elements. The structure and composition of the material was characterized via powder X-ray diffraction (PXRD), Mössbauer spectroscopy (MB), scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and energy dispersive X-ray spectroscopy (EDX). Two preparation methods of pentlandite bulk electrodes are presented. In the first approach a piece of synthetic pentlandite rock is directly contacted via a wire ferrule. The second approach utilizes pentlandite pellets, pressed from finely ground powder, which is immobilized in a Teflon casing. Both electrodes, whilst being prepared by an additive-free method, reveal high durability during electrocatalytic conversions in comparison to common drop-coating methods. We herein showcase the striking performance of such electrodes to accomplish the hydrogen evolution reaction (HER) and present a standardized method to evaluate the electrocatalytic performance by electrochemical and gas chromatographic methods. Furthermore, we report stability tests via potentiostatic methods at an overpotential of 0.6 V to explore the material limitations of the electrodes during electrolysis under industrial relevant conditions.
Methanol Synthesis with Steel Mill Gases: Performance Investigations in an On‐Site Technical Center
(2021)
In the present contribution, the utilization of steel-mill gases for an industrial methanol synthesis process is described. The focus of this work is on the influence of syngas compositions derived from steel-mill gases on an industrial Cu/ZnO/Al2O3 catalyst. Elevated CO2 and H2O concentrations seem to have an irreversible impact on the activity of the catalyst. In order to obtain realistic gas composition for the catalyst tests, a process simulation of the methanol synthesis was conducted. The calculated gas compositions at the reactor inlet were applied in a practical test in order to evaluate the catalyst stability under steel mill gas conditions. No noticeable deactivation was observed.
Hochschulreport 2020
(2021)