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The task of the Center for Language Research is to provide content-based English language instruction for students of computer science and engineering. As such, we find ourselves at the confluence of many of the streams currently running through the English Language Teaching profession, including English for Science and Technology (EST), English for Academic Purposes (EAP), English for Specific Purposes (ESP), Computer-assisted language learning (CALL), content-based instruction, and multimedia applications in foreign language pedagogy. This paper describes our initial attempts to construct a number of World Wide Web pages where students will be able to study EST, EAP, and computer science topics on their own in a multimedia environment.
Education at the University of Aizu is focussed upon computer science. Besides being the subject matter of many courses, however, the computer also plays a vital role in the educational process itself, both in the distribution of instructional media, and in providing students with valuable practical experience. All students have unlimited access (24-hours-a-day) to individual networked workstations, most of which are multimedia-capable (even video capture is possible in two exercise rooms). Without software and content tailored for computer-aided instruction, the hardware becomes an expensive decoration. In any case, there is a need to better educate the instructors and students in the use of the equipment. In the interest of facilitating effective, collaborative use of network-based computers in teaching, this article explores the impact that a network environment can have on such activities. First, as a general overview, and to examine the motivation for the use of a network environment in teaching, this article reviews a range of different styles of collaboration. Then the article shows what kind of tools are available for use, within the context of what has come to be called Computer-Supported Cooperative Work (CSCW).
The Sound Spatialization Framework is a C++ toolkit and development environment for providing advanced sound spatialization for virtual reality and multimedia applications. The Sound Spatialization Framework provides many powerful display and user-interface features not found in other sound spatialization software packages. It provides facilities that go beyond simple sound source spatialization: visualization and editing of the soundscape, multiple sinks, clustering of sound sources, monitoring and controlling resource management, support for various spatialization backends, and classes for MIDI animation and handling.
The construction of a basis of a certain lattice of interest is a basic tool in many fields of algorithmic number theory. All too often we can not compute with the original lattices because of irrational numbers involved but have to work with approximations of them. While helpful bounds were shown about the reduction of lattice bases in cite{buchmann94reducing}, here we introduce the notion of a $(epsilon,delta)$-constructable basis of a lattice and determine the precision of vectors that is necessary to extend a set to a $(epsilon,delta)$-constructable basis.
Cell migration is associated with the dynamic protrusion of a thin actin-based cytoskeletal extension at the cell front, which has been shown to consist of two different substructures, the leading lamellipodium and the subsequent lamellum. While the formation of the lamellipodium is increasingly well understood, organizational principles underlying the emergence of the lamellum are just beginning to be unraveled. We report here on a 1D mathematical model which describes the reaction-diffusion processes of a polarized actin network in steady state, and reproduces essential characteristics of the lamellipodium-lamellum system. We observe a steep gradient in filament lengths at the protruding edge, a local depolymerization maximum a few microns behind the edge, as well as a differential dominance of the network destabilizer ADF/cofilin and the stabilizer tropomyosin. We identify simple and robust organizational principles giving rise to the derived network characteristics, uncoupled from the specifics of any molecular implementation, and thus plausibly valid across cell types. An analysis of network length dependence on physico-chemical system parameters implies that to limit array treadmilling to cellular dimensions, network growth has to be truncated by mechanisms other than aging-induced depolymerization, e.g., by myosin-associated network dissociation at the transition to the cell body. Our work contributes to the analytical understanding of the cytoskeletal extension's bisection into lamellipodium and lamellum and sheds light on how cells organize their molecular machinery to achieve motility.
Despite their overwhelming complexity, living cells display a high degree of internal mechanical and functional organization which can largely be attributed to the intracellular biopolymer scaffold, the cytoskeleton. Being a very complex system far from thermodynamic equilibrium, the cytoskeleton's ability to organize is at the same time challenging and fascinating. The extensive amounts of frequently interacting cellular building blocks and their inherent multifunctionality permits highly adaptive behavior and obstructs a purely reductionist approach. Nevertheless (and despite the field's relative novelty), the physics approach has already proved to be extremely successful in revealing very fundamental concepts of cytoskeleton organization and behavior. This review aims at introducing the physics of the cytoskeleton ranging from single biopolymer filaments to multicellular organisms. Throughout this wide range of phenomena, the focus is set on the intertwined nature of the different physical scales (levels of complexity) that give rise to numerous emergent properties by means of self-organization or self-assembly.
To power dynamic processes in cells, the actin and microtubule cytoskeletons organize into complex structures. Although it is known that cytoskeletal coordination is vital for cell function, the mechanisms by which cross-linking proteins coordinate actin and microtubule activities remain poorly understood. In particular, it is unknown how the distinct mechanical properties of different actin architectures modulate the outcome of actin-microtubule interactions. To address this question, we engineered the protein TipAct, which links growing microtubule ends via end-binding proteins to actin filaments. We show that growing microtubules can be captured and guided by stiff actin bundles, leading to global actin-microtubule alignment. Conversely, growing microtubule ends can transport, stretch and bundle individual actin filaments, thereby globally defining actin filament organization. Our results provide a physical basis to understand actin-microtubule cross-talk, and reveal that a simple cross-linker can enable a mechanical feedback between actin and microtubule organization that is relevant to diverse biological contexts.
Marktdaten
(2018)
Die in der Schriftenreihe Trading verwendeten Forschungsdaten beinhalten historische Kursdaten, geliefert von Lenz+Partner AG (Deutschland), für eine Auswahl an Aktien. Die Datei „FEBRDUSA_1“ zeigt diese Auswahl in Form der deutschen Wertpapierkennnummer (Spalte „Titel“), des Handelszeitraums (Spalten „Beginn“ und „Ende“) und des Aktiennamens. Kursdaten sind in dieser Datei nicht enthalten, sondern liegen in einer umfangreichen Datenbank vor.
Die Marktdaten umfassen 867 Aktien und sind das Ergebnis eines im Jahr 2015 durchgeführten Auswahlprozesses mit dem Ziel, Datenqualität und Handelbarkeit der Aktien zu verbessern. Es wurden folgende Bedingungen gefordert:
- Die Aktien werden an der Frankfurter Börse gehandelt.
- Sie sind in einem der deutschen Aktienindizes DAX, MDAX, TECDAX, SDAX, HDAX, CDAX, Technology All Share, Prime All Share und GEX oder in den amerikanischen Aktienindizes S&P 500 oder Nasdaq 100 gelistet.
- Die Kursdaten der in Frankfurt gehandelten Aktien enden nicht vor dem Jahr 2014.
- Der (unbereinigte) Eröffnungskurs Ende 2013 beträgt mindestens 1 EUR. Diese Bedingung soll dazu beitragen, das Handeln von „penny stocks“ zu verhindern.
Die vorliegende Marktdefinition resultierte in 867 Aktien, die frühestens am 11. Dezember 2014 enden, sodass eine Auswertung der Marktdaten mit vollständigen Kurswerten bis zu diesem Zeitpunkt möglich ist. Der Markt ist groß genug, um interessante Kaufbedingungen mit einer ausreichend großen Anzahl an Kaufkandidaten zu untersuchen.