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Cell migration is associated with the dynamic protrusion of a thin actin-based cytoskeletal extension at the cell front, which has been shown to consist of two different substructures, the leading lamellipodium and the subsequent lamellum. While the formation of the lamellipodium is increasingly well understood, organizational principles underlying the emergence of the lamellum are just beginning to be unraveled. We report here on a 1D mathematical model which describes the reaction-diffusion processes of a polarized actin network in steady state, and reproduces essential characteristics of the lamellipodium-lamellum system. We observe a steep gradient in filament lengths at the protruding edge, a local depolymerization maximum a few microns behind the edge, as well as a differential dominance of the network destabilizer ADF/cofilin and the stabilizer tropomyosin. We identify simple and robust organizational principles giving rise to the derived network characteristics, uncoupled from the specifics of any molecular implementation, and thus plausibly valid across cell types. An analysis of network length dependence on physico-chemical system parameters implies that to limit array treadmilling to cellular dimensions, network growth has to be truncated by mechanisms other than aging-induced depolymerization, e.g., by myosin-associated network dissociation at the transition to the cell body. Our work contributes to the analytical understanding of the cytoskeletal extension's bisection into lamellipodium and lamellum and sheds light on how cells organize their molecular machinery to achieve motility.
282 - Fachbereichsordnung für den Fachbereich Medien der Fachhochschule Düsseldorf vom 28.11.2011
(2011)
Aufgrund des § 26 Abs. 3 Satz 2 des Gesetzes über die Hochschulen des Landes Nordrhein-Westfalen (Hochschulgesetz-HG) in der Fassung vom 01.01.2007, der Grundordnung der Fachhochschule Düsseldorf vom 12.07.2010 geändert durch Satzung vom 26.10.2011 hat der Fachbereichsrat des Fachbereichs Medien der Fachhochschule Düsseldorf folgende Fachbereichsordnung erlassen: