Systematic review on health effects of long-term exposure to UFP

  • BACKGROUND AND AIM [|] Due to their small size, ultrafine particles (UFP≤100nm) can reach deeply into the lungs and could exert higher toxicity on the body organs in comparison with fine particulate matter. Only ten epidemiological studies examined long-term UFP exposure and health effects according to the most recent review from 2019 that included studies until 2017. We systematically reviewed the literature on health effects of long-term exposure to UFP. METHOD [|] Epidemiological studies were searched comprehensively in PubMed and LUDOK (the Swiss literature database on air pollution and health) from January 2017 to September 2023. Original epidemiologic studies were included if they reported on the general or sub-populations, assessed long-term exposure of UFP measures, investigated clinical or preclinical health outcomes and reported a quantifiable measure of association. Internal validity of studies was evaluated with a risk of bias instrument. The project is funded by theBACKGROUND AND AIM [|] Due to their small size, ultrafine particles (UFP≤100nm) can reach deeply into the lungs and could exert higher toxicity on the body organs in comparison with fine particulate matter. Only ten epidemiological studies examined long-term UFP exposure and health effects according to the most recent review from 2019 that included studies until 2017. We systematically reviewed the literature on health effects of long-term exposure to UFP. METHOD [|] Epidemiological studies were searched comprehensively in PubMed and LUDOK (the Swiss literature database on air pollution and health) from January 2017 to September 2023. Original epidemiologic studies were included if they reported on the general or sub-populations, assessed long-term exposure of UFP measures, investigated clinical or preclinical health outcomes and reported a quantifiable measure of association. Internal validity of studies was evaluated with a risk of bias instrument. The project is funded by the Federal Ministry for the Environment, Nature Conversation, Nuclear Safety and Consumer Protection and supervised by the German Environment Agency (FKZ 3721 61 202 0). RESULTS [|] We identified 53 original studies investigating long-term associations. The vast majority were cohort studies (79.2%) conducted in the general population (62.3%). Half (54.7%) were located in western Europe. UFP was measured and modelled in various ways; more than a third of the studies (41.5%) used land-use regression models. Thirty studies adjusted for at least one co-pollutant. Most identified outcomes were cardiometabolic (43.4%), respiratory (13.2%) and birth outcomes (13.2%). Positive associations with long-term UFP exposure were reported for cardiometabolic, respiratory and birth outcomes for 78.5%, 42.9% and 50.0% of studies, respectively. CONCLUSIONS [|] The evidence base has increased substantially since the publication of the 2019 review. Positive associations were reported, in particular for cardiometabolic outcomes.show moreshow less

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Author:Pascale Haddad, Haeran JeongORCiD, Ron Kappeler, Hicran AltugORCiD, Zorana Jovanovic AndersenORCiD, Marie BergmannORCiD, Hanna BoogaardORCiD, Meltem Joss KutlarORCiD, Youn Hee LimORCiD, Steffen LoftORCiD, Tobias PohlORCiD, Barbara HoffmannORCiD
open access:Diamant - ohne Publikationskosten mit Lizenzhinweis
Fachbereich/Einrichtung:Hochschule Düsseldorf / Fachbereich - Maschinenbau und Verfahrenstechnik
Document Type:Conference Proceeding
Year of Completion:2024
Language of Publication:English
Publisher:Environmental Health Perspectives
Place of publication:Durham, NC
Parent Title (English):ISEE Conference Abstracts
Volume:2024
Issue:1
DOI:https://doi.org/10.1289/isee.2024.0574
ISSN:1078-0475
Tag:Ultrafeinstaub
GND Keyword:Exposition (Medizin); Luftverschmutzung; Umweltmedizin; Epidemiologie
Licence (German):keine Lizenz - nur Metadaten
Release Date:2025/01/24
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