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Emergent complexity of the cytoskeleton: from single filaments to tissue

  • Despite their overwhelming complexity, living cells display a high degree of internal mechanical and functional organization which can largely be attributed to the intracellular biopolymer scaffold, the cytoskeleton. Being a very complex system far from thermodynamic equilibrium, the cytoskeleton's ability to organize is at the same time challenging and fascinating. The extensive amounts of frequently interacting cellular building blocks and their inherent multifunctionality permits highly adaptive behavior and obstructs a purely reductionist approach. Nevertheless (and despite the field's relative novelty), the physics approach has already proved to be extremely successful in revealing very fundamental concepts of cytoskeleton organization and behavior. This review aims at introducing the physics of the cytoskeleton ranging from single biopolymer filaments to multicellular organisms. Throughout this wide range of phenomena, the focus is set on the intertwined nature of the differentDespite their overwhelming complexity, living cells display a high degree of internal mechanical and functional organization which can largely be attributed to the intracellular biopolymer scaffold, the cytoskeleton. Being a very complex system far from thermodynamic equilibrium, the cytoskeleton's ability to organize is at the same time challenging and fascinating. The extensive amounts of frequently interacting cellular building blocks and their inherent multifunctionality permits highly adaptive behavior and obstructs a purely reductionist approach. Nevertheless (and despite the field's relative novelty), the physics approach has already proved to be extremely successful in revealing very fundamental concepts of cytoskeleton organization and behavior. This review aims at introducing the physics of the cytoskeleton ranging from single biopolymer filaments to multicellular organisms. Throughout this wide range of phenomena, the focus is set on the intertwined nature of the different physical scales (levels of complexity) that give rise to numerous emergent properties by means of self-organization or self-assembly.show moreshow less

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    © 2013 The Author(s). Published by Taylor & Francis. This is an Open Access article. Non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly attributed, cited, and is not altered, transformed, or built upon in any way, is permitted. The moral rights of the named author(s) have been asserte

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Author:Florian HuberORCiD, Jörg Schnauß, S. Rönicke, P. Rauch, K. Müller, C. Fütterer, Josef Käs
open access (DINI-Set):open_access
Fachbereich/Einrichtung:Hochschule Düsseldorf / Fachbereich - Medien
Document Type:Article
Year of Completion:2013
Language of Publication:English
Publisher:Taylor & Francis
Parent Title (English):Advances in Physics
Volume:62
Issue:1
First Page:1
Last Page:112
URN:urn:nbn:de:hbz:due62-opus-34812
Related URL:http://www.ncbi.nlm.nih.gov/pubmed/24748680
DOI:https://doi.org/10.1080/00018732.2013.771509
ISSN:1460-6976
Dewey Decimal Classification:0 Informatik, Informationswissenschaft, allgemeine Werke / 00 Informatik, Wissen, Systeme / 004 Datenverarbeitung; Informatik
Licence (German):Creative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International
Release Date:2021/11/22
Note:
Acknowledgment:
We thank Klaus Kroy, Dan Strehle, Tobias Kießling, Matti Gralka, Harald Herrmann, Denis Wirtz, and Michael Höckel for very helpful comments, discussions, and proof reading. We further like to thank Steve Pawlizak, Thomas Fuhs, Daniel Koch, BjöStuhrmann, and Franziska Wetzel for contributing data and additional illustrations. This work was supported by the graduate school “Building with Molecules and Nano-Objects” (BuildMoNa).
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