TY - JOUR A1 - Deckert, Carsten A1 - Schomaker, Rahel M. T1 - Cultural tightness–looseness and national innovativeness: impacts of tolerance and diversity of opinion JF - Journal of Innovation and Entrepreneurship N2 - The links between innovativeness as a driver of economic performance, and the determinants of innovativeness have been investigated by management scholars and economists for decades, focusing mostly on “hard factors” as investment in research and development, or education. Focusing on a relatively neglected, but in times of globalization even more important aspect, the infuence of cultural characteristics on innovativeness, we apply diferent econometric models to test for links between cultural tightness and looseness on the one hand, and national innovativeness on the other hand. We fnd that cultural tightness—in the sense of homogenous and intolerant societies—has a negative link to national innovativeness, while cultural looseness—in the sense of tolerant and diverse societies—displays a positive link to national innovativeness. KW - DOAJ KW - DEAL KW - Innovation KW - Kultur KW - Toleranz KW - Diversity of opinion Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-36515 SN - 2192-5372 VL - 11 SP - 1 EP - 19 PB - Springer Nature ER - TY - JOUR A1 - Krebs, Christian A1 - Müller, Patrick A1 - Braun, Alexander T1 - Impact of Windshield Optical Aberrations on Visual Range Camera Based Classification Tasks Performed by CNNs JF - London Imaging Meeting Y1 - 2021 SN - 0-89208-346-6 U6 - https://doi.org/10.2352/issn.2694-118X.2021.LIM-83 SN - 2694-118X VL - 2021 IS - 1 SP - 83 EP - 87 PB - Ingenta connect ER - TY - JOUR A1 - Müller, Patrick A1 - Brummel, Mattis A1 - Braun, Alexander T1 - Spatial recall index for machine learning algorithms JF - London Imaging Meeting N2 - We present a novel metric Spatial Recall Index to assess the performance of machine-learning (ML) algorithms for automotive applications, focusing on where in the image which performance occurs. Typical metrics like intersection-over-union (IoU), precisionrecallcurves or average precision (AP) quantify the performance over a whole database of images, neglecting spatial performance variations. But as the optics of camera systems are spatially variable over the field of view, the performance of ML-based algorithms is also a function of space, which we show in simulation: A realistic objective lens based on a Cooke-triplet that exhibits typical optical aberrations like astigmatism and chromatic aberration, all variable over field, is modeled. The model is then applied to a subset of the BDD100k dataset with spatially-varying kernels. We then quantify local changes in the performance of the pre-trained Mask R-CNN algorithm. Our examples demonstrate the spatial dependence of the performance of ML-based algorithms from the optical quality over field, highlighting the need to take the spatial dimension into account when training ML-based algorithms, especially when looking forward to autonomous driving applications. Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-35657 SN - 0-89208-346-6 VL - 2021 IS - 1 SP - 58 EP - 62 PB - Society for Imaging Science and Technology ER - TY - JOUR A1 - Millard, Jeremy A1 - Sorivelle, Marie A1 - Deljanin, Sarah A1 - Unterfrauner, Elisabeth A1 - Voigt, Christian T1 - Is the Maker Movement Contributing to Sustainability? JF - Sustainability KW - DOAJ Y1 - 2018 U6 - https://doi.org/10.3390/su10072212 SN - 2071-1050 N1 - 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). VL - 10 IS - 7 PB - MDPI ER - TY - JOUR A1 - Seebacher, Lisa M. A1 - Vana, Irina A1 - Voigt, Christian A1 - Tschank, Juliet T1 - Is Science for Everyone? Exploring Intersectional Inequalities in Connecting With Science JF - Frontiers in Education KW - DOAJ Y1 - 2021 UR - www.frontiersin.org/articles/10.3389/feduc.2021.673850/full#supplementary-material U6 - https://doi.org/10.3389/feduc.2021.673850 SN - 2504-284X N1 - The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/feduc.2021.673850/full#supplementary-material. Copyright © 2021 Seebacher, Vana, Voigt and Tschank. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms E-ISSN(s): VL - 6 PB - Frontiers ER - TY - JOUR A1 - Huber, Florian A1 - Strehle, Dan A1 - Schnauß, Jörg A1 - Käs, Josef T1 - Formation of regularly spaced networks as a general feature of actin bundle condensation by entropic forces JF - New Journal of Physics KW - DOAJ Y1 - 2015 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-34833 SN - 1367-2630 VL - 17 IS - 4 PB - IOP Publishing ER - TY - JOUR A1 - Huber, Florian A1 - van der Burg, Sven A1 - van der Hooft, Justin J. J. A1 - Ridder, Lars T1 - MS2DeepScore: a novel deep learning similarity measure to compare tandem mass spectra JF - Journal of Cheminformatics N2 - Mass spectrometry data is one of the key sources of information in many workflows in medicine and across the life sciences. Mass fragmentation spectra are generally considered to be characteristic signatures of the chemical compound they originate from, yet the chemical structure itself usually cannot be easily deduced from the spectrum. Often, spectral similarity measures are used as a proxy for structural similarity but this approach is strongly limited by a generally poor correlation between both metrics. Here, we propose MS2DeepScore: a novel Siamese neural network to predict the structural similarity between two chemical structures solely based on their MS/MS fragmentation spectra. Using a cleaned dataset of > 100,000 mass spectra of about 15,000 unique known compounds, we trained MS2DeepScore to predict structural similarity scores for spectrum pairs with high accuracy. In addition, sampling different model varieties through Monte-Carlo Dropout is used to further improve the predictions and assess the model's prediction uncertainty. On 3600 spectra of 500 unseen compounds, MS2DeepScore is able to identify highly-reliable structural matches and to predict Tanimoto scores for pairs of molecules based on their fragment spectra with a root mean squared error of about 0.15. Furthermore, the prediction uncertainty estimate can be used to select a subset of predictions with a root mean squared error of about 0.1. Furthermore, we demonstrate that MS2DeepScore outperforms classical spectral similarity measures in retrieving chemically related compound pairs from large mass spectral datasets, thereby illustrating its potential for spectral library matching. Finally, MS2DeepScore can also be used to create chemically meaningful mass spectral embeddings that could be used to cluster large numbers of spectra. Added to the recently introduced unsupervised Spec2Vec metric, we believe that machine learning-supported mass spectral similarity measures have great potential for a range of metabolomics data processing pipelines. KW - DOAJ Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-34847 UR - http://www.ncbi.nlm.nih.gov/pubmed/34715914 SN - 1758-2946 N1 - J.J.J.v.d.H. acknowledges funding from an ASDI eScience grant, ASDI.2017.030, from the Netherlands eScience Center. VL - 13 IS - 1 PB - Cold Spring Harbor Laboratory ER - TY - JOUR A1 - Preciado López, Magdalena A1 - Huber, Florian A1 - Grigoriev, Ilya A1 - Steinmetz, Michel O. A1 - Akhmanova, Anna A1 - Koenderink, Gijsje H. A1 - Dogterom, Marileen T1 - Actin-microtubule coordination at growing microtubule ends JF - Nature Communications N2 - To power dynamic processes in cells, the actin and microtubule cytoskeletons organize into complex structures. Although it is known that cytoskeletal coordination is vital for cell function, the mechanisms by which cross-linking proteins coordinate actin and microtubule activities remain poorly understood. In particular, it is unknown how the distinct mechanical properties of different actin architectures modulate the outcome of actin-microtubule interactions. To address this question, we engineered the protein TipAct, which links growing microtubule ends via end-binding proteins to actin filaments. We show that growing microtubules can be captured and guided by stiff actin bundles, leading to global actin-microtubule alignment. Conversely, growing microtubule ends can transport, stretch and bundle individual actin filaments, thereby globally defining actin filament organization. Our results provide a physical basis to understand actin-microtubule cross-talk, and reveal that a simple cross-linker can enable a mechanical feedback between actin and microtubule organization that is relevant to diverse biological contexts. KW - DOAJ Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-34878 SN - 2041-1723 VL - 5 PB - Springer Nature ER - TY - JOUR A1 - Adamatzky, Andrew A1 - Huber, Florian A1 - Schnauß, Jörg T1 - Computing on actin bundles network JF - Scientific Reports N2 - Actin filaments are conductive to ionic currents, mechanical and voltage solitons. These travelling localisations can be utilised to generate computing circuits from actin networks. The propagation of localisations on a single actin filament is experimentally unfeasible to control. Therefore, we consider excitation waves propagating on bundles of actin filaments. In computational experiments with a two-dimensional slice of an actin bundle network we show that by using an arbitrary arrangement of electrodes, it is possible to implement two-inputs-one-output circuits. Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-34665 UR - http://www.ncbi.nlm.nih.gov/pubmed/31685834 SN - 2045-2322 VL - 9 IS - 1 PB - Springer Nature ER - TY - JOUR A1 - Adamatzky, Andrew A1 - Schnauß, Jörg A1 - Huber, Florian T1 - Actin droplet machine JF - Royal Society Open Science N2 - The actin droplet machine is a computer model of a three-dimensional network of actin bundles developed in a droplet of a physiological solution, which implements mappings of sets of binary strings. The actin bundle network is conductive to travelling excitations, i.e. impulses. The machine is interfaced with an arbitrary selected set of k electrodes through which stimuli, binary strings of length k represented by impulses generated on the electrodes, are applied and responses are recorded. The responses are recorded in a form of impulses and then converted to binary strings. The machine's state is a binary string of length k: if there is an impulse recorded on the ith electrode, there is a '1' in the ith position of the string, and '0' otherwise. We present a design of the machine and analyse its state transition graphs. We envisage that actin droplet machines could form an elementary processor of future massive parallel computers made from biopolymers. Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-34675 UR - http://www.ncbi.nlm.nih.gov/pubmed/31903204 SN - 2054-5703 N1 - A.A. was partially supported by EPSRC grant no. EP/P016677/1. The authors declare that they have no competing interests. VL - 6 IS - 12 PB - Royal Soc. Publ. ER - TY - JOUR A1 - Huber, Florian A1 - Ridder, Lars A1 - Verhoeven, Stefan A1 - Spaaks, Jurriaan H. A1 - Diblen, Faruk A1 - Rogers, Simon A1 - van der Hooft, Justin J. J. T1 - Spec2Vec: Improved mass spectral similarity scoring through learning of structural relationships JF - PLOS Computational Biology N2 - Spectral similarity is used as a proxy for structural similarity in many tandem mass spectrometry (MS/MS) based metabolomics analyses such as library matching and molecular networking. Although weaknesses in the relationship between spectral similarity scores and the true structural similarities have been described, little development of alternative scores has been undertaken. Here, we introduce Spec2Vec, a novel spectral similarity score inspired by a natural language processing algorithm-Word2Vec. Spec2Vec learns fragmental relationships within a large set of spectral data to derive abstract spectral embeddings that can be used to assess spectral similarities. Using data derived from GNPS MS/MS libraries including spectra for nearly 13,000 unique molecules, we show how Spec2Vec scores correlate better with structural similarity than cosine-based scores. We demonstrate the advantages of Spec2Vec in library matching and molecular networking. Spec2Vec is computationally more scalable allowing structural analogue searches in large databases within seconds. Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-34687 UR - http://www.ncbi.nlm.nih.gov/pubmed/33591968 SN - 1553-7358 N1 - Data Availability Statement: The pre-processed, cleaned dataset with all positive ionization mode spectra can be downloaded from https://doi.org/10.5281/zenodo.3978118, the original raw data can be accessed from https://doi.org/10.5281/zenodo.3979010. Funding: J.J.J.v.d.H. acknowledges funding from an ASDI eScience grant, ASDI.2017.030, from the Netherlands eScience Center—NLeSC, www.esciencecenter.nl, The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. VL - 17 IS - 2 PB - Cold Spring Harbor Laboratory ER - TY - JOUR A1 - Benim, Ali Cemal A1 - Pfeiffelmann, Björn T1 - Comparison of Combustion Models for Lifted Hydrogen Flames within RANS Framework JF - Energies KW - DOAJ Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-27727 SN - 1996-1073 VL - 13 IS - 1 PB - MDPI ER - TY - JOUR A1 - Fomin, Alexey A1 - Petelin, Daniil A1 - Jahr, Andreas T1 - Synthesis and Analysis of a Novel Linkage Mechanism with the Helical Motion of the End-Effector JF - Robotics Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-27736 SN - 2218-6581 N1 - Supplementary Material ist verfügbar: https://www.mdpi.com/2218-6581/9/3/53/s1 (Zip mit mov-Datei) VL - 9 IS - 3 SP - 1 EP - 15 PB - MDPI ER - TY - JOUR A1 - Shahzad, Azeem A1 - Gulistan, Uzma A1 - Ali, Ramzan A1 - Iqbal, Azhar A1 - Benim, Ali Cemal A1 - Kamran, Muhammad A1 - Khan, Salah Ud-Din A1 - Khan, Shahab Ud-Din A1 - Farooq, Aamir T1 - Numerical Study of Axisymmetric Flow and Heat Transfer in a Liquid Film over an Unsteady Radially Stretching Surface JF - Mathematical Problems in Engineering Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-27755 N1 - Acknowledgments The authors would like to sincerely appreciate funding from Researchers Supporting Project (no. RSP-2020/58), King Saud University, Riyadh, Saudi Arabia. R. Ali acknowledges the School of Art and Sciences, University of Central Asia, Kyrgyz Republic, for travel grant to visit the Department of Basic Sciences, UET, Taxila, and CFS, Düsseldorf. VL - 2020 SP - 1 EP - 9 PB - Hindawi ER - TY - JOUR A1 - Girod, Kai A1 - Lohmann, Heiko A1 - Schlüter, Stefan A1 - Kaluza, Stefan T1 - Methanol Synthesis with Steel-Mill Gases: Simulation and Practical Testing of Selected Gas Utilization Scenarios JF - Processes Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-26928 VL - 8 IS - 12 PB - MDPI ER - TY - JOUR A1 - Glembin, Jens A1 - Adam, Mario A1 - Deidert, Jörn A1 - Jagnow, Kati A1 - Rockendorf, Gunter A1 - Wirth, Hans Peter T1 - Simulation and Evaluation of Different Boiler Implementations and Configurations in Solar Thermal Combi Systems JF - Energy Procedia KW - Kessel und große Solarthermieanlagen Y1 - 2012 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-27350 N1 - Acknowledgements The work presented in this paper has been realized within the project “Integration von Heizkesseln in Wärmeverbundsysteme mit großen Solaranlagen“ (Integration of heating boilers in thermal energy distribution circuits with large solar systems), which has been funded by the German Ministry for Environment, Nature Conservation and Nu-clear Safety based on a decision of the German Federal Parliament (FKZ 0325958Z). Within the project, the authors developed a new boiler model for dynamic simulations and validated it against test rig and field data. Field measurements and additional system simulations have been used to analyze and evaluate the interaction of the solar thermal system and the boiler. The authors are grateful for the project support. The content of this publication is in the responsibility of the authors. VL - 30 SP - 601 EP - 610 PB - Elsevier ER - TY - JOUR A1 - Schramm, Sebastian A1 - Adam, Mario T1 - Storage in Solar Process Heat Applications JF - Energy Procedia KW - Solare-Prozesswärme-Standards Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-27244 SN - 1876-6102 N1 - PII: S1876610214003981 VL - 48 SP - 1202 EP - 1209 PB - Elsevier ER - TY - JOUR A1 - Kernebeck, Sven A1 - Holle, Daniela A1 - Pogscheba, Patrick A1 - Jordan, Felix A1 - Mertl, Fabian A1 - Huldtgren, Alina A1 - Bader, Sebastian A1 - Kirste, Thomas A1 - Teipel, Stefan A1 - Holle, Bernhard A1 - Halek, Margareta T1 - A Tablet App- and Sensor-Based Assistive Technology Intervention for Informal Caregivers to Manage the Challenging Behavior of People With Dementia (the insideDEM Study): Protocol for a Feasibility Study JF - JMIR research protocols Y1 - 2019 U6 - https://doi.org/10.2196/11630 VL - 8 IS - 2 PB - JMIR ER - TY - JOUR A1 - Möllmann, Anne A1 - Hunger, Antje A1 - Dusend, Christina A1 - van den Hout, Marcel A1 - Buhlmann, Ulrike T1 - Gazing at facial features increases dissociation and decreases attractiveness ratings in non-clinical females - A potential explanation for a common ritual in body dysmorphic disorder JF - PloS one N2 - Rituals, such as gazing at faces, are common in body dysmorphic disorder (BDD) and appear in cognitive-behavioral models as a maintaining factor. Rituals are also common in obsessive-compulsive disorder (OCD). In contrast to OCD, the proposed associations between rituals and intrusive thoughts/appearance preoccupation have not been empirically investigated for BDD. We examined if the assumed effect of gazing rituals on attractiveness ratings exists and if it is associated with dissociation. In an experiment, we asked N = 65 non-clinical females to focus on the nose of a photographed face at pre- and post-test. In between, participants gazed at the nose of either the same (relevant gazing) or another face (irrelevant gazing). We found increasing dissociation after gazing in both conditions and a differentially stronger decrease of attractiveness ratings in the relevant gazing condition. Our findings support the hypothesized effect of gazing rituals on attractiveness evaluation in cognitive-behavioral models for BDD. Y1 - 2019 U6 - https://doi.org/10.1371/journal.pone.0219791 VL - 14 IS - 7 PB - PLoS ER - TY - JOUR A1 - Langmann, Reinhard T1 - Distributed Web-Based Control System JF - International Journal of Online Engineering (iJOE) Y1 - 2010 U6 - https://doi.org/10.3991/ijoe.v6i3.1345 VL - 6 IS - 3 PB - iJOE ER - TY - JOUR A1 - Bhattacharyya, Suvanjan A1 - Chattopadhyay, Himadri A1 - Banerjee, Arnab A1 - Benim, Ali Cemal T1 - Heat transfer and flow field in a circular twisted channel JF - MATEC Web of Conferences Y1 - 2018 U6 - https://doi.org/10.1051/matecconf/201824001005 VL - 240 PB - edp sciences ER - TY - JOUR A1 - Niemann, Jörg A1 - Pisla, Adrian T1 - Sustainable Potentials and Risks Assess in Automation and Robotization Using the Life Cycle Management Index Tool—LY-MIT JF - Sustainability KW - FLiX KW - DOAJ Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-27966 SN - 2071-1050 VL - 10 IS - 12 PB - MDPI ER -