TY - CHAP A1 - Rakow, Thomas C. ED - Ebling, Dirk T1 - Werkzeuge zur Unterstützung der Kollaboration in Präsenzumgebungen T2 - Forschungsreport 2013 N2 - Werkzeuge zur Kollaboration unterstützen die Beteiligten bei der gemeinsamen Bearbeitung einer Aufgabe. Diese Aufgaben sind so vielfältig wie die Erstellung eines Dokuments, einer Enzyklopädie, einer Website, eines Maschinenbauteils oder einer Werbekampagne. KW - E-Business KW - FHD Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-17506 UR - https://nbn-resolving.org/urn:nbn:de:hbz:due62-opus-8662 SP - 78 EP - 79 PB - Fachhochschule Düsseldorf CY - Düsseldorf ER - TY - JOUR A1 - Preciado López, Magdalena A1 - Huber, Florian A1 - Grigoriev, Ilya A1 - Steinmetz, Michel O. A1 - Akhmanova, Anna A1 - Koenderink, Gijsje H. A1 - Dogterom, Marileen T1 - Actin-microtubule coordination at growing microtubule ends JF - Nature Communications N2 - To power dynamic processes in cells, the actin and microtubule cytoskeletons organize into complex structures. Although it is known that cytoskeletal coordination is vital for cell function, the mechanisms by which cross-linking proteins coordinate actin and microtubule activities remain poorly understood. In particular, it is unknown how the distinct mechanical properties of different actin architectures modulate the outcome of actin-microtubule interactions. To address this question, we engineered the protein TipAct, which links growing microtubule ends via end-binding proteins to actin filaments. We show that growing microtubules can be captured and guided by stiff actin bundles, leading to global actin-microtubule alignment. Conversely, growing microtubule ends can transport, stretch and bundle individual actin filaments, thereby globally defining actin filament organization. Our results provide a physical basis to understand actin-microtubule cross-talk, and reveal that a simple cross-linker can enable a mechanical feedback between actin and microtubule organization that is relevant to diverse biological contexts. KW - DOAJ Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-34878 SN - 2041-1723 VL - 5 PB - Springer Nature ER -