TY - JOUR A1 - Huber, Florian A1 - Strehle, Dan A1 - Schnauß, Jörg A1 - Käs, Josef T1 - Formation of regularly spaced networks as a general feature of actin bundle condensation by entropic forces JF - New Journal of Physics KW - DOAJ Y1 - 2015 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-34833 SN - 1367-2630 VL - 17 IS - 4 PB - IOP Publishing ER - TY - JOUR A1 - Huber, Florian A1 - Verhoeven, Stefan A1 - Meijer, Christiaan A1 - Spreeuw, Hanno A1 - Castilla, Efraín A1 - Geng, Cunliang A1 - van der Hooft, Justin J. J. A1 - Rogers, Simon A1 - Belloum, Adam A1 - Diblen, Faruk A1 - Spaaks, Jurriaan H. T1 - matchms - processing and similarity evaluation of mass spectrometry data JF - Journal of Open Source Software KW - DOAJ Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-34856 SN - 2475-9066 VL - 5 IS - 52 PB - Cold Spring Harbor Laboratory ER - TY - JOUR A1 - Stuhrmann, Björn A1 - Huber, Florian A1 - Käs, Josef T1 - Robust organizational principles of protrusive biopolymer networks in migrating living cells JF - Plos One N2 - Cell migration is associated with the dynamic protrusion of a thin actin-based cytoskeletal extension at the cell front, which has been shown to consist of two different substructures, the leading lamellipodium and the subsequent lamellum. While the formation of the lamellipodium is increasingly well understood, organizational principles underlying the emergence of the lamellum are just beginning to be unraveled. We report here on a 1D mathematical model which describes the reaction-diffusion processes of a polarized actin network in steady state, and reproduces essential characteristics of the lamellipodium-lamellum system. We observe a steep gradient in filament lengths at the protruding edge, a local depolymerization maximum a few microns behind the edge, as well as a differential dominance of the network destabilizer ADF/cofilin and the stabilizer tropomyosin. We identify simple and robust organizational principles giving rise to the derived network characteristics, uncoupled from the specifics of any molecular implementation, and thus plausibly valid across cell types. An analysis of network length dependence on physico-chemical system parameters implies that to limit array treadmilling to cellular dimensions, network growth has to be truncated by mechanisms other than aging-induced depolymerization, e.g., by myosin-associated network dissociation at the transition to the cell body. Our work contributes to the analytical understanding of the cytoskeletal extension's bisection into lamellipodium and lamellum and sheds light on how cells organize their molecular machinery to achieve motility. KW - DOAJ Y1 - 2011 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-34901 SN - 1932-6203 N1 - Funding: This work has been supported by the Leipzig Graduate College ‘‘GK 1097 InterNeuro - Interdisciplinary Approaches in Cellular Neuroscience’’ (http:// www.uni-leipzig.de/˜ineuro/) and the Graduate School ‘‘Leipzig School of Natural Sciences - Building with Molecules and Nano-objects (BuildMoNa)’’ (http://www. buildmona.de/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. VL - 6 IS - 1 PB - Public Library of Science (PLoS) ER - TY - JOUR A1 - Preciado López, Magdalena A1 - Huber, Florian A1 - Grigoriev, Ilya A1 - Steinmetz, Michel O. A1 - Akhmanova, Anna A1 - Koenderink, Gijsje H. A1 - Dogterom, Marileen T1 - Actin-microtubule coordination at growing microtubule ends JF - Nature Communications N2 - To power dynamic processes in cells, the actin and microtubule cytoskeletons organize into complex structures. Although it is known that cytoskeletal coordination is vital for cell function, the mechanisms by which cross-linking proteins coordinate actin and microtubule activities remain poorly understood. In particular, it is unknown how the distinct mechanical properties of different actin architectures modulate the outcome of actin-microtubule interactions. To address this question, we engineered the protein TipAct, which links growing microtubule ends via end-binding proteins to actin filaments. We show that growing microtubules can be captured and guided by stiff actin bundles, leading to global actin-microtubule alignment. Conversely, growing microtubule ends can transport, stretch and bundle individual actin filaments, thereby globally defining actin filament organization. Our results provide a physical basis to understand actin-microtubule cross-talk, and reveal that a simple cross-linker can enable a mechanical feedback between actin and microtubule organization that is relevant to diverse biological contexts. KW - DOAJ Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-34878 SN - 2041-1723 VL - 5 PB - Springer Nature ER - TY - GEN T1 - 855 - Zweite Satzung zur Änderung der Prüfungsordnung für den gemeinsamen Bachelorstudiengang Ton und Bild an der Hochschule Düsseldorf und der Robert Schumann Hochschule Düsseldorf vom 31.08.2022 BT - 31.08.2022 - Änderung 2 der PO 2018 N2 - Aufgrund der §§ 2 Abs. 4, 64 Abs. 1 des Gesetzes über die Hochschulen des Landes Nordrhein- Westfalen (Hochschulgesetz - HG) vom 16.09.2014 (GV. NRW. S. 547) in der aktuell gültigen Fassung haben die Hochschule Düsseldorf und die Robert Schumann Hochschule Düsseldorf einvernehmlich die folgende Ordnung als Satzung erlassen. T3 - Amtliche Mitteilungen : Verkündungsblatt der Hochschule Düsseldorf - 855 KW - Amtliche Mitteilungen KW - Ordnung KW - Prüfungsrecht KW - Robert Schumann Hochschule KW - Bachelor KW - Ton und Bild KW - PO2018 KW - Prüfungsordnung Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-38167 CY - Düsseldorf ER - TY - THES A1 - Leuer, Sebastian T1 - Sharper Crypto-API Analysis: Entwicklung eines integrierten Plugins zur statischen Code-Analyse der Nutzung von Krypto-APIs in C# N2 - Untersuchungen haben ergeben, dass bis zu 95% aller verfügbaren Android Apps mindestens einen Programmierfehler bei der Verwendung von sogenannten Krypto-APIs besitzen. Bei korrekter Anwendung dieser APIs können mit ihnen sensible System- und Benutzerdaten vor Angriffen geschützt werden. Bisher gibt es nur wenige verfügbare Tool-basierte Hilfsmittel für Programmierer, welche die Verwendungsfehler identifzieren können. Für die Programmiersprache Java konnten bislang nur sehr wenige dieser spezialisierten Hilfsmittel gefunden werden, darunter das statische Codeanalysetool CogniCrypt. Ein derartiges Werkzeug für C# konnte nicht gefunden werden. Diese Arbeit befasst sich mit der Entwicklung eines Plugins für die IDE Visual Studio zur statischen Codeanalyse namens Sharper Crypto-API Analysis. Sein Hauptziel ist, Programmierern beim Verwenden der .NET Krypto-API mit der Programmiersprache C# zu unterstützen. Durch Beobachtungen im Entwicklungsprozess sollen einerseits die Parallelen und Unterschiede zwischen der Java- und der C#-Welt im Umgang mit Krypto-APIs erkennbar werden. Andererseits beschreibt diese Arbeit den erforderlichen Aufwand, um ein hoch spezialisiertes, statisches Codeanalysetool zu entwickeln. Die Beobachtungen zeigen, dass die Unterschiede der Java- und C#-Technologien nicht oberflächlich, sondern hauptsächlich im Detail liegen und daher während der Implementierung des Tools besondere Aufmerksamkeit erfordern. Die Entwicklungsphase selbst zeigt sich als besonders anspruchsvoll, da mit Unsicherheitsfaktoren bezüglich der Funktions- und Verhaltensweisen von Visual Studio umgegangen werden müssen. Das Hauptziel von Sharper Crypto-API Analysis konnte durch die Implementation von vier Hauptfunktionsgruppen umgesetzt werden. Die wichtigste von ihnen ist das Bereitstellen von Codeanalysen, welche ausschließlich auf die Verwendung der .NET Krypto-API spezialisiert sind. Die hier entwickelten Codeanalysen betrachten besonders Fehlerquellen, die Programmierer am häufigsten begehen. Um den Programmierern nachhaltig Wissen bezüglich der Krypto-API zu vermitteln, führt diese Arbeit erweiterte Analyseberichte ein, die zusätzlich über Schwachstellen oder Angriffsszenarien informieren. Besonderheiten und Alleinstellungsmerkmale der anderen Funktionsgruppen werden in dieser Arbeit unter besonderer Berücksichtigung von Implementationshinweisen dokumentiert. N2 - Recent researches have shown that up to 95% of all available Andriod Apps contain at least one programming error caused by wrongly applying so-called Crypto-APIs. By using these APIs, applications can ensure protection of sensitive data against attacks. Currently there is a very limited amount of program-based tools available which help programmers identifying their mistakes in using Crypto-APIs. The programming language Java seems to be most prominent as many of the few tools found are specialized for this language. One of them is called CogniCrypt. A specialized tool for the C# programming language however could not be found. The thesis at hand addresses the development of a static code analysis plugin for the IDE Visual Studio called Sharper Crypto-API Analysis. To assist programmers using the .NET Crypto-API in C# shall be its main goal. Observations during the development process shall point out differences between the Java and C# ecosystems in handling Crypto-APIs. Furthermore the work at hand describes the necessary expenditure to develop a static code analysis tool. On the one hand the observations show differences between Java and C#, which only become obvious after a careful examination. Hence, attention must be paid during the implmentation of the tool. On the other hand the development process revealed itsself to be challenging because of unpredictable and undocumented behaviour of the host platform Visual Studio. The main goal of Sharper Crypto-API Analysis could be achieved by implementing four primary function classes. The most important class contains code analyzers which investigate exspecially the usage of the .NET Crypto-API. In particular the analysis specialized at errors which programmers tend to do most commonly. In addition to analyzing bare source code the tool also presents more detailed reports that shall help programmers to understand weaknesses and attacks their code allows to perform and most importantly how to fix the identified issues. Lastly this work will also document the other function classes and point out their features and behaviours with a special consideration on implementation details. KW - Krypto-API KW - C# KW - Plug in KW - Statische Analyse Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-16430 CY - Düsseldorf ER - TY - CHAP A1 - von Berg, Markus A1 - Prinz, Lukas A1 - Steffens, Jochen T1 - Comparing individual perception of timbre and reverberance BT - Proceedings of the 24th International Congress on Acoustics N2 - Room reverberation alters the spatial impression and timbre of a sound by modulating its spectral and temporal characteristics. Thus, we argue that, on a perceptual level, reverberation basically breaks down into interaural differences and spectro-temporal cues and that the separation of a perceived timbre into a sound source and a surrounding room is a purely cognitive process. To investigate the connection between the perception of reverberation cues and timbre analysis, the sensitivity for changes in reverberation was compared to timbre perception abilities. The Timbre Perception Test was used to measure the perception of the temporal envelope, spectral centroid, and spectral flux of artificial sounds. Sensitivity for changes in reverberation time was tested with a discrimination task using speech and noise with speech-alike spectral and temporal envelopes as source signals. Musical and acoustical expertise was assessed through the Goldsmiths Musical Sophistication Index and self-reports on experience with and knowledge of acoustics. There was a considerable correlation between timbre and reverberance perception ability, but timbre perception and academic experience predicted only 41% of the variance in reverberance perception. Still, perception abilities related to similar acoustical phenomena seem to be better indicators of listening skills than self-reports on acoustical or musical expertise. KW - Timbre KW - Klangfarbe KW - Reverberation KW - Nachhall Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-38706 UR - https://ica2022korea.org/data/Proceedings_A11.pdf CY - Gyeoungju, Südkorea ER - TY - THES A1 - Wolff, Philipp-Sebastian T1 - Ein Tutorial über die Erstellung einer Microservicearchitektur in einer Continuous Delivery Umgebung basierend auf Best-Practice N2 - Die Digitalisierung fordert kontinuierlich neue Services für bestehende Produkte, revolutioniert Produktionsmethoden und verändert Geschäftsmodelle. Continuous Delivery bietet in der agilen Softwareentwicklung mit kurzen Entwicklungszyklen die Antwort auf diesen Wandel. Die Verwendung einer Continuous Delivery-Umgebung (CD-Umgebung) erfordert einerseits zwar einen initialen Einrichtungsaufwand. Andererseits kann durch den Einsatz einer CD-Umgebung das gesamte Projekt an Schnelligkeit gewinnen. In Kombination mit Microservice-Architekturen lassen sich kleine Deployment-Einheiten umsetzen. Microservice-Architekturen bringen einen Mehrwert durch Flexibilität, Skalierung, Automatisierung, standardisierte Schnittstellen und Ausfallsicherheit. Microservices fungieren autark in verteilten Systemen und weisen nur sehr geringe Abhängigkeiten zu anderen Services auf. Die Kommunikation findet über einheitliche Schnittstellen statt, weshalb Implementierungsdetails der Microservices nach außen betrachtet irrelevant sind. Für die Umsetzung der CD-Umgebung wird der web-basierte Git-Repository-Manager GitLab in Kombination mit der Container-Orchestrierungsplattform Kubernetes verwendet, da sich beide Programme einfach integrieren lassen. Innerhalb eines Tutorials wird, basierend auf Best Practices anhand des Beispiels der HSD-Card, erläutert wie eine Microservice-Architektur mit Spring Boot, als Anwendung umgesetzt werden kann. Für die Erstellung der Microservice-Architektur legt das Tutorial Schwerpunkte auf die Verwendung von Software Design Pattern (DDD), die Struktur innerhalb Spring Boot, die Kommunikation via REST sowie die Skalierung, das Load-Balancing und die Überführung in die CD-Umgebung. KW - Microservice Continuous Delivery Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-19437 CY - Düsseldorf ER - TY - THES A1 - Mehlhorn, Nils T1 - Mobile Cross-Platform Development from a Progressive Perspective N2 - Progressive web applications (PWAs) seem to be the next big thing in the mobile landscape. These are web applications with “super-powers” which are meant to provide the kinds of user experiences previously only native mobile applications could. Therefore they are able to match native applications in their capabilities but still thrive on the reachability of the web. They achieve this by implementing certain characteristics which originate from innovative standards and sophisticated best practices. Conveniently, as it is the web, PWAs are working seamlessly cross-platform. One of the closest things to a PWA so far may be an application created with the NativeScript framework. Such an application is also developed with web technologies yet able to use any native interface directly. This is made possible by using a designated runtime for mediating between JavaScript and the mobile system. Eventually, NativeScript is able to offer a high degree nativity yet also of convenient abstraction during development. This paper is set out to deliver further insight into both approaches by contrasting them based on the characteristics of PWAs. For this purpose, these characteristics are elaborated and adjusted to be applicable to native mobile applications. Hence a reasonable basis for what to expect from a native application is derived. Then NativeScript is assessed on this basis by the means of transferable concepts and technologies as well as a prototypic mobile application. Finally, an informed discussion and conclusion is performed based on the results. The comprehensive characteristics of PWAs resolve previous shortcomings with well thought out concepts and new technologies. These are transferable to native mobile applications to a far extent and may also be put into practice with NativeScript. The framework’s approach may be very well called ingenious, however, in the long run it might fall short of the innovative concept of PWAs. Having said this, it is still able to serve as a practical measure for creating appealing user experiences for multiple systems with arguably little effort. Due to large overlap a transformation between the two application types is a realistic option. Either way, web technologies are far from what they used to be and it is exciting to see how the mobile and web landscape will evolve in the future. KW - NativeScript KW - Progressive Web Apps KW - Cross-Plattform Entwicklung KW - NativeScript KW - Progressive Web Apps KW - cross-platform development Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-11285 ER - TY - CHAP A1 - Herder, Jens A1 - Büntig, Fabian A1 - Daemen, Jeff A1 - Lang, Jaroslaw A1 - Lück, Florian A1 - Säger, Mitja A1 - Sörensen, Roluf A1 - Hermanni, Markus A1 - Vonolfen, Wolfgang T1 - Subtle Animations using Talent Tracking in a Virtual (TV) Studio T2 - 17th International Conference on Human and Computer N2 - Markerless talent tracking is widely used for interactions and animations within virtual environments. In a virtual (tv) studio talents could be overburden by interaction tasks because camera and text require extensive attention. We take a look into animations and inter- actions within a studio, which do not require any special attention or learning. We show the generation of an artificial shadow from a talent, which ease the keying process, where separation of real shadows from the background is a difficult task. We also demonstrate animations of footsteps and dust. Furthermore, capturing talents’ height can also be used to adjust the parameters of elements in the virtual environment, like the position and scaling of a virtual display. In addition to the talents, a rigid body was tracked as placeholder for graphics, easing the interaction tasks for a talent. Two test productions show the possibilities, which subtle animations offer. In the second production, the rendering was improved (shadows, filtering, normal maps, ...) and instead of using the rigid body to move an object (a flag), the animation was only controlled by the hand’s position. KW - talent tracking KW - virtual studios KW - realtime animations KW - FHD KW - Virtual (TV) Studio Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-16009 UR - http://vsvr.medien.hs-duesseldorf.de/publications/hc2014-subtle-animations-abstract.html CY - Hamamatsu/Aizu-Wakamatsu/Duesseldorf ER - TY - JOUR A1 - Lepa, Steffen A1 - Steffens, Jochen A1 - Herzog, Martin A1 - Egermann, Hauke T1 - Popular Music as Entertainment Communication: How Perceived Semantic Expression Explains Liking of Previously Unknown Music JF - Media and Communication Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-23602 VL - 8 IS - 3 SP - 191 EP - 204 PB - Cogitatio ER - TY - RPRT A1 - Weidekamp-Maicher, Manuela T1 - Technikberatung als integrierter Baustein der Wohnberatung: Anforderungen an professionelle Technikberatung aus Sicht ausgewählter Expert*innen N2 - Technikberatung stellt eine neue soziale Dienstleistung dar, die angesichts der steigenden Potenziale assistiver digitaler Technologien an Relevanz gewinnt. Der Bericht befasst sich mit der Bestimmung von Anforderungen an professionelle Technikberatung als integriertem Baustein der Wohnberatung in Nordrhein-Westfalen (Deutschland). Das methodische Vorgehen beruht auf 20 Expert*inneninterviews. Die Befragten repräsentieren verschiedene Handlungsfelder, u. a. Wohn- und Technikberatung, Technikentwicklung, Wohnungswirtschaft, Wissenschaft, Kommunalpolitik, Pflegekassen usw. Die Ergebnisse führten zur Bildung von drei Kernthemen: Anforderungen an professionelle Technikberatung, Rahmenbedingungen und Aufgaben von Technikberatung auf institutioneller und gesamtgesellschaftlicher Ebene sowie Erwartungen an Politik, Wissenschaft und andere Akteure. Zusammenfassend betrachtet zeigt sich, dass Technikberatung neue Kompetenzen benötigt, deren Vermittlung auf Dauer, z. B. durch spezifische Schulungen, institutionalisiert werden muss. Die Integration von Technikberatung in die Wohnberatung erweitert zudem ihre Aufgaben, ihren Beratungsanspruch und erfordert den Aufbau neuer Kooperationen. Ihr Erfolg ist von einer Reihe förderlicher Rahmenbedingungen abhängig, z. B. politischer, ökonomischer, qualifikatorischer und ideeller Art. Eine Transformation aller sozialen Beratungsleistungen kann jedoch nicht allein aus der Perspektive der Wohnberatung vorangetrieben werden, sondern muss alle Beratungsstrukturen im kommunalen Raum berücksichtigen. N2 - Technology counselling represents a new social service that is gaining relevance in view of the increasing potential of assistive digital technologies. The report deals with the identification of requirements for professional technology counselling as an integrated component of housing counselling in North Rhine-Westphalia (Germany). The methodological approach is based on 20 interviews with experts. The interviewees represent various fields of action, including housing and technology counselling, technology development, companies in the housing sector, science, local politics, long-term care insurance companies, etc. The results led to the formation of three core themes: Requirements for professional technology counselling, framework conditions and tasks of technology counselling on an institutional and societal level, and expectations on politics, science and other actors. In summary, it can be seen that technology counselling requires new competences, the teaching of which must be institutionalized in the long term, e.g. through specific training courses. The integration of technology counselling into housing counselling also expands its tasks, its counselling claim and requires the establishment of new cooperations. Its success depends on a number of conducive framework conditions, e.g. political, economic, qualification and idealistic. However, a transformation of all social counselling services cannot be driven forward from the perspective of housing counselling alone but must take into account all counselling structures in the municipal space. KW - Wohnberatung KW - Wohnen im Alter KW - assistive Technik KW - Technikberatung Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-39044 SN - 978-3-941334-36-6 CY - Düsseldorf ER - TY - JOUR A1 - Kampa, Miriam A1 - Finke, Johannes A1 - Stalder, Tobias A1 - Bucher, Leandra A1 - Klapperich, Holger A1 - Mertl, Fabian A1 - Zimmer, Christian A1 - Geiger, Christian A1 - Hassenzahl, Marc A1 - Klucken, Tim T1 - Facilitating relaxation and stress reduction in healthy participants through a virtual reality intervention: study protocol for a non-inferiority randomized controlled trial JF - Trials KW - MIREVI Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-40118 SN - 1745-6215 N1 - Open Access funding enabled and organized by Projekt DEAL. This work is funded by the Bundesministerium für Bildung und Forschung (BMBF, Funding number: 16SV8068). The funding source was not involved in the study design; the collection, analysis, and interpretation of data; in the writing of the report; or the decision to submit the article for publication. (see SPIRIT item 4). VL - 23 PB - BMC ER - TY - CHAP A1 - von Berg, Markus A1 - Schwörer, Paul A1 - Prinz, Lukas A1 - Steffens, Jochen T1 - Analysis of physical and perceptual properties of room impulse responses: development of an online tool T2 - Forum Acusticuum 2023: 10th Convention of European Acoustics Association, Turin, Italy, 11th-15th September 2023 N2 - Over the past decades, research in room acoustics has established several derivative measures of an impulse response, some of which are incorporated in the ISO 3382 standards. These parameters intend to represent perceptual qualities, but were developed without a consistent modeling of room acoustical perception. More recent research proposed comprehensive inventories of room acoustic perception that are purely based on evaluations by human subjects, such as the Room Acoustical Quality Index (RAQI). In this work RA-QI scores acquired for 70 room impulse responses were predicted from room acoustical parameters. Except for Reverberance, the prediction of RAQI factors performed rather poor. In most cases, the sound source had a greater impact on RAQI scores. All analyses are published in an online tool, where users can upload omnidirectional and binaural impulse responses, and instantly obtain and visualize several physical descriptors, as well as predicted RAQI scores for three different sound sources. So far, acceptable prediction accuracy is achieved for Reverberance, Strength, Irregular Decay, Clarity and Intimacy. Larger data sets of evaluated impulse responses are required to improve the model performance and enable reliable predictions of room acoustical quality. Therefore, the administration of RAQI evaluations within the website is currently being developed. Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-41955 PB - EAA ER - TY - JOUR A1 - Schreiber, Andreas A1 - Struminksi, Regina T1 - Visualizing the Provenance of Personal Data Using Comics JF - Computers KW - DOAJ Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-40286 SN - 2073-431X VL - 7 IS - 1 PB - MDPI ER - TY - JOUR A1 - Huber, Florian A1 - van der Burg, Sven A1 - van der Hooft, Justin J. J. A1 - Ridder, Lars T1 - MS2DeepScore: a novel deep learning similarity measure to compare tandem mass spectra JF - Journal of Cheminformatics N2 - Mass spectrometry data is one of the key sources of information in many workflows in medicine and across the life sciences. Mass fragmentation spectra are generally considered to be characteristic signatures of the chemical compound they originate from, yet the chemical structure itself usually cannot be easily deduced from the spectrum. Often, spectral similarity measures are used as a proxy for structural similarity but this approach is strongly limited by a generally poor correlation between both metrics. Here, we propose MS2DeepScore: a novel Siamese neural network to predict the structural similarity between two chemical structures solely based on their MS/MS fragmentation spectra. Using a cleaned dataset of > 100,000 mass spectra of about 15,000 unique known compounds, we trained MS2DeepScore to predict structural similarity scores for spectrum pairs with high accuracy. In addition, sampling different model varieties through Monte-Carlo Dropout is used to further improve the predictions and assess the model's prediction uncertainty. On 3600 spectra of 500 unseen compounds, MS2DeepScore is able to identify highly-reliable structural matches and to predict Tanimoto scores for pairs of molecules based on their fragment spectra with a root mean squared error of about 0.15. Furthermore, the prediction uncertainty estimate can be used to select a subset of predictions with a root mean squared error of about 0.1. Furthermore, we demonstrate that MS2DeepScore outperforms classical spectral similarity measures in retrieving chemically related compound pairs from large mass spectral datasets, thereby illustrating its potential for spectral library matching. Finally, MS2DeepScore can also be used to create chemically meaningful mass spectral embeddings that could be used to cluster large numbers of spectra. Added to the recently introduced unsupervised Spec2Vec metric, we believe that machine learning-supported mass spectral similarity measures have great potential for a range of metabolomics data processing pipelines. KW - DOAJ Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-34847 UR - http://www.ncbi.nlm.nih.gov/pubmed/34715914 SN - 1758-2946 N1 - J.J.J.v.d.H. acknowledges funding from an ASDI eScience grant, ASDI.2017.030, from the Netherlands eScience Center. VL - 13 IS - 1 PB - Cold Spring Harbor Laboratory ER - TY - JOUR A1 - Steffens, Jochen A1 - Wilczek, Tobias A1 - Weinzierl, Stefan T1 - Junk Food or Haute Cuisine to the Ear? – Investigating the Relationship Between Room Acoustics, Soundscape, Non-Acoustical Factors, and the Perceived Quality of Restaurants JF - Frontiers in Built Environment N2 - Sound and music are well-studied aspects of the quality of experience in restaurants; the role of the room acoustical conditions, their influence on the visitors’ soundscape evaluation and their impact on the overall customer satisfaction in restaurants, however, has received less scientific attention. The present field study therefore investigated whether sound pressure level, reverberation time, and soundscape pleasantness can predict factors associated with overall restaurant quality. In total, 142 persons visiting 12 restaurants in Berlin rated relevant acoustical and non-acoustical factors associated with restaurant quality. Simultaneously, the A-weighted sound pressure level (LA,eq,15) was measured, and the reverberation time in the occupied state (T20,occ) was obtained by measurements performed in the unoccupied room and a subsequent calculation of the occupied condition according to DIN 18041. Results from linear mixed-effects models revealed that both the LA,eq,15 and T20,occ had a significant influence on soundscape pleasantness and eventfulness, whereby the effect of T20,occ was meditated by the LA,eq,15. Also, the LA,eq,15 as well as soundscape pleasantness were significant predictors of overall restaurant quality. A comprehensive structural equation model including both acoustical and non-acoustical factors, however, indicates that the effect of soundscape pleasantness on overall restaurant quality is mediated by the restaurant’s atmosphere. Our results support and extend previous findings which suggest that the acoustical design of restaurants involves a trade-off between comfort and liveliness, depending on the desired character of the place. KW - DOAJ Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-32115 SN - 2297-3362 N1 - The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fbuil.2021.676009/full#supplementary-material; ut:000655121500001 VL - 676009 PB - Frontiers ER - TY - JOUR A1 - Haberfehlner, Helga A1 - van de Ven, Shankara S. A1 - van der Burg, Sven A. A1 - Huber, Florian A1 - Georgievska, Sonja A1 - Aleo, Ignazio A1 - Harlaar, Jaap A1 - Bonouvrié, Laura A. A1 - van der Krogt, Marjolein M. A1 - Buizer, Annemieke I. T1 - Towards automated video-based assessment of dystonia in dyskinetic cerebral palsy: A novel approach using markerless motion tracking and machine learning JF - Frontiers in Robotics and AI Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-40592 SN - 2296-9144 VL - 10 PB - Frontiers ER - TY - JOUR A1 - Wojciechowski, Manfred A1 - Pogscheba, Patrick T1 - Building a COVID-Safe Navigation App Using a Meta-Model Based Context Server JF - sensors N2 - Building context-aware applications is an already widely researched topic. It is our belief that context awareness has the potential to supplement the Internet of Things, when a suitable methodology including supporting tools will ease the development of context-aware applications. We believe that a meta-model based approach can be key to achieving this goal. In this paper, we present our meta-model based methodology, which allows us to define and build application-specific context models and the integration of sensor data without any programming. We describe how that methodology is applied with the implementation of a relatively simple context-aware COVID-safe navigation app. The outcome showed that programmers with no experience in context-awareness were able to understand the concepts easily and were able to effectively use it after receiving a short training. Therefore, context-awareness is able to be implemented within a short amount of time. We conclude that this can also be the case for the development of other context-aware applications, which have the same context-awareness characteristics. We have also identified further optimization potential, which we will discuss at the conclusion of this article. KW - context awareness KW - internet of things KW - development methodology KW - meta model KW - context query language Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-39570 SN - 1424-8220 VL - 22 IS - 24 SP - 1 EP - 14 PB - MDPI ER - TY - GEN T1 - 896 - Erste Satzung zur Änderung der Fachbereichsordnung für den Fachbereich Medien der Hochschule Düsseldorf vom 07.08.2023 N2 - Aufgrund der §§ 2 Abs. 4 S. 1, 26 Abs. 3 S. 2 des Gesetzes über die Hochschulen des Landes Nordrhein-Westfalen (Hochschulgesetz - HG) vom 16.09.2014 (GV. NRW. S. 547) in der aktuell gültigen Fassung und der Grundordnung der Hochschule Düsseldorf vom 08.10.2015 (Verkündungsblatt der Hochschule Düsseldorf, Amtliche Mitteilung Nr. 414) in der aktuell gültigen Fassung hat die Hochschule Düsseldorf die folgende Ordnung als Satzung erlassen. T3 - Amtliche Mitteilungen : Verkündungsblatt der Hochschule Düsseldorf - 896 KW - Amtliche Mitteilungen Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-41424 CY - Düsseldorf ER -