TY - JOUR A1 - Voss, Karsten A1 - Musall, Eike A1 - Lichtmeß, Markus T1 - From Low Energy to Net Zero-Energy Buildings: Status and Perspectives JF - Journal of Green Building N2 - “Net Zero-Energy Building” has become a popular catchphrase to describe the synergy between energy-efficient building and renewable energy utilisation to achieve a balanced energy budget over an annual cycle. Taking into account the energy exchange with a grid overcomes the limitations of energy-autonomous buildings with the need for seasonal energy storage on-site. Although the expression, “Net Zero-Energy Building,” appears in many energy policy documents, a harmonised definition or a standardised balancing method is still lacking. This paper reports on the background and the various effects influencing the energy balance approach. After discussing the national energy code framework in Germany, a harmonised terminology and balancing procedure is proposed. The procedure takes not only the energy balance but also energy efficiency and load matching into account. KW - Eigene Methodik Y1 - 2011 U6 - https://doi.org/10.3992/jgb.6.1.46 VL - 6 IS - 1 SP - 46 EP - 57 PB - College Publishing ER - TY - JOUR A1 - Voss, Karsten A1 - Musall, Eike T1 - Null- und Plusenergiegebäude: Allgemeine Bilanzierungsverfahren und Schnittstellen zur normativen Praxis in Deutschland JF - EnEVaktuell N2 - Die Begriffe „Nullenergiehaus“ oder „Plusenergiehaus“ sind in den letzten Jahren national und international zum Inbegriff für die konsequente Zusammenführung von Maßnahmen zur drastischen Energieeinsparung und optimierter, dezentraler Nutzung erneuerbarer Energien geworden. Dabei geht es nicht um energieautarke Gebäude und die dabei große Herausforderung der saisonalen Energiespeicherung. Grundidee ist, dass die von einem Gebäude in ein Netz eingespeiste Energiemenge in der Jahresbilanz mindestens dem Energiebezug entspricht. Sowohl im Kontext der Fortführung der europäischen Gebäuderichtline als auch im aktuellen Energiekonzept und Energieforschungsprogramm der Bundesregierung wird das Thema besetzt. KW - Nullenergiehaus KW - Energieinsparung Y1 - 2011 UR - https://www.btga-arch.uni-wuppertal.de/fileadmin/architektur/btga-arch/btga_veroeffentlichungen/btga_zeitschrift/Null-_und_Plusenergiegeb%EF%BF%BDude_EnEVaktuell_12_2011.pdf IS - IV SP - 3 EP - 5 PB - DIN Deutsches Institut für Normung e.V. ER - TY - JOUR A1 - Musall, Eike A1 - Voss, Karsten T1 - Renewable Energy Ratio in Net Zero Energy Buildings JF - REHVA Journal KW - Bilanzierung KW - Definitionsbeschrieb Y1 - 2014 UR - https://www.rehva.eu/rehva-journal/chapter/renewable-energy-ratio-in-net-zero-energy-buildings VL - 51 IS - 3 SP - 14 EP - 18 PB - REHVA ER - TY - JOUR A1 - de Bánffy-Hall, Alicia A1 - Hill, Burkhard T1 - Community Music: Eine Einführung JF - KULTURELLE BILDUNG ONLINE Y1 - 2017 UR - https://doi.org/10.25529/92552.79 U6 - https://doi.org/10.25529/92552.79 PB - Bundesakademie für Kulturelle Bildung ER - TY - JOUR A1 - de Bánffy-Hall, Alicia A1 - Hill, Burkhard T1 - Community Music: Eine Einführung JF - kubi-online Y1 - 2017 UR - https://www.kubi-online.de/artikel/community-music-einfuehrung ER - TY - JOUR A1 - Hörner, Fernand T1 - La flexibilité historique de l’aura : de Walter Benjamin à Radiohead JF - Communication & Langages Y1 - 2015 U6 - https://doi.org/10.4074/S0336150015012041 N1 - © NecPlus. Tous droits réservés pour tous pays VL - 2 IS - 184 SP - 61 EP - 77 PB - cairn-int.info ER - TY - JOUR A1 - Tophoven, Silke T1 - Buchbesprechung: Siegrist, J./Wahrendorf, M. (Hrsg.) (2016): Work Stress and Health in a Globalized Economy. The Model of Effort-Reward Imbalance. Cham: Springer International Publishing JF - WSI-Mitteilungen Y1 - 2017 UR - https://www.nomos-elibrary.de/10.5771/0342-300X-2017-3-224/buchbesprechung-jahrgang-70-2017-heft-3 VL - 70 IS - 3 PB - Nomos ER - TY - JOUR A1 - Tophoven, Silke A1 - Tisch, Anita T1 - Dimensionen prekärer Beschäftigung und Gesundheit im mittleren Lebensalter JF - WSI-Mitteilungen Y1 - 2016 UR - https://doi.org/10.5771/0342-300X-2016-2-105 U6 - https://doi.org/10.5771/0342-300X-2016-2-105 VL - 69 IS - 2 SP - 105 EP - 112 PB - Nomos ER - TY - JOUR A1 - Rauch, Angela A1 - Tophoven, Silke A1 - Eggs, Johannes A1 - Tisch, Anita T1 - Arbeitsbezogene gesundheitsrelevante Faktoren im fortgeschrittenen Erwerbsalter: eine Studie mit neuen Analysemöglichkeiten JF - WSI-Mitteilungen Y1 - 2015 U6 - https://doi.org/10.5771/0342-300X-2015-3-212 VL - 68 IS - 3 SP - 212 EP - 218 PB - Nomos ER - TY - JOUR A1 - Willers, Christoph A1 - Deckert, Carsten T1 - eFood in Deutschland JF - Der Betriebswirt N2 - Im Vergleich zu „Pionierbranchen“ wie Mode oder Medien steht der Online-Handel mit Lebensmitteln erst am Anfang. Dabei kann dieser zu einem Wettbewerbsvorteil werden – wenn der Handel es richtig angeht. Auf der anderen Seite steht das Risiko einer strategischen Falle, d.h. es wird unter Umständen aufgrund der Widerstände beim Verbraucher nur ein Nischenmarkt bedient, der eine geringe Profitabilität aufweist. Im Spannungsfeld „Marktpotenzial auf Handelsseite“ vs. „Zurückhaltung beim Verbraucher“ rücken dabei Fragen der Kommunikationspolitik im Online-Lebensmittelhandel in den Fokus. Für eine erfolgreiche Umsetzung stellt eine eindeutige Typologie eine notwendige Basis dar, um die konkreten Bedürfnisse potenzieller Konsumenten anzusprechen. Ein Engagement im eFood-Bereich ist daher als Investition in die zukünftige Entwicklung der Märkte und ihrer Zielgruppen zu betrachten. Although online trading in the food sector is still in early stages, it may become a competitive edge – if retailers go about it the right way. On the other hand, due to consumer resistance, there is the risk of serving only a niche market, which cannot be maintained in terms of profitability. Therefore, a stronger focus on communication policies is needed. Engaging in the eFood sector finally has to be seen as an important investment into future markets and their target groups. Keywords: online lebensmittelhandel, lieferfenster, informationszeitalter, face to the customer Y1 - 2015 U6 - https://doi.org/10.3790/dbw.56.4.10 VL - 56 IS - 11 SP - 10 EP - 15 PB - Duncker & Humblot ER - TY - JOUR A1 - Kampa, Miriam A1 - Finke, Johannes A1 - Stalder, Tobias A1 - Bucher, Leandra A1 - Klapperich, Holger A1 - Mertl, Fabian A1 - Zimmer, Christian A1 - Geiger, Christian A1 - Hassenzahl, Marc A1 - Klucken, Tim T1 - Facilitating relaxation and stress reduction in healthy participants through a virtual reality intervention: study protocol for a non-inferiority randomized controlled trial JF - Trials KW - MIREVI Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-40118 SN - 1745-6215 N1 - Open Access funding enabled and organized by Projekt DEAL. This work is funded by the Bundesministerium für Bildung und Forschung (BMBF, Funding number: 16SV8068). The funding source was not involved in the study design; the collection, analysis, and interpretation of data; in the writing of the report; or the decision to submit the article for publication. (see SPIRIT item 4). VL - 23 PB - BMC ER - TY - JOUR A1 - Galban, Craig A1 - Maderwald, Stefan A1 - Eggebrecht, Holger A1 - Grote, Wolfgang A1 - de Greiff, A. A1 - Uffmann, K. A1 - Ladd, M. E. T1 - Monitoring the Effects of Chronic Obstructive Pulmonary Disease on Muscle Elasticity by MR Elastography JF - Proc. Intl. Soc. Mag. Reson. Med. N2 - Men afflicted with chronic obstructive pulmonary disease (COPD) show signs of muscle dysfunction, such as increased muscle fatigue and acidosis during exercise. We hypothesize that muscle elasticity of the lower extremities differs between patients with COPD and age-related controls. The shear modulus of the soleus muscle was measured non-invasively using MR elastography (MRE) at 0%, 5%, 10%, 15%, and 20% of the subject’s maximum applied force. The results from this study showed statistical differences between the patients and controls, even though there were no statistical differences in the maximum applied force. Y1 - 2005 UR - https://cds.ismrm.org/protected/05MProceedings/PDFfiles/02015.pdf VL - 13 SP - 2015 ER - TY - JOUR A1 - Galban, Craig A1 - Maderwald, Stefan A1 - Herrmann, Burkhard A1 - Brauck, K. A1 - Grote, Wolfgang A1 - de Greiff, A. A1 - Uffmann, K. A1 - Ladd, M. T1 - Measuring Skeletal Muscle Elasticity in Patients with Hypogonadism by MR Elastography JF - Proc. Intl. Soc. Mag. Reson. Med. N2 - Men afflicted with hypogonadism have reduced fat-free mass and in some cases a loss in muscle strength. We hypothesize that muscle elasticity of the lower extremities differs between patients with hypogonadism and healthy controls. The shear modulus of the soleus muscle was measured non-invasively using MR elastography (MRE) at 0%, 5%, 10%, 15%, and 20% of the subject’s maximum applied force. The results from this study showed statistical differences between the patients and controls, even though there were no statistical differences in applied force. Y1 - 2005 UR - https://cds.ismrm.org/protected/05MProceedings/PDFfiles/02016.pdf VL - 13 SP - 2016 ER - TY - JOUR A1 - Huber, Florian A1 - van der Burg, Sven A1 - van der Hooft, Justin J. J. A1 - Ridder, Lars T1 - MS2DeepScore: a novel deep learning similarity measure to compare tandem mass spectra JF - Journal of Cheminformatics N2 - Mass spectrometry data is one of the key sources of information in many workflows in medicine and across the life sciences. Mass fragmentation spectra are generally considered to be characteristic signatures of the chemical compound they originate from, yet the chemical structure itself usually cannot be easily deduced from the spectrum. Often, spectral similarity measures are used as a proxy for structural similarity but this approach is strongly limited by a generally poor correlation between both metrics. Here, we propose MS2DeepScore: a novel Siamese neural network to predict the structural similarity between two chemical structures solely based on their MS/MS fragmentation spectra. Using a cleaned dataset of > 100,000 mass spectra of about 15,000 unique known compounds, we trained MS2DeepScore to predict structural similarity scores for spectrum pairs with high accuracy. In addition, sampling different model varieties through Monte-Carlo Dropout is used to further improve the predictions and assess the model's prediction uncertainty. On 3600 spectra of 500 unseen compounds, MS2DeepScore is able to identify highly-reliable structural matches and to predict Tanimoto scores for pairs of molecules based on their fragment spectra with a root mean squared error of about 0.15. Furthermore, the prediction uncertainty estimate can be used to select a subset of predictions with a root mean squared error of about 0.1. Furthermore, we demonstrate that MS2DeepScore outperforms classical spectral similarity measures in retrieving chemically related compound pairs from large mass spectral datasets, thereby illustrating its potential for spectral library matching. Finally, MS2DeepScore can also be used to create chemically meaningful mass spectral embeddings that could be used to cluster large numbers of spectra. Added to the recently introduced unsupervised Spec2Vec metric, we believe that machine learning-supported mass spectral similarity measures have great potential for a range of metabolomics data processing pipelines. KW - DOAJ Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-34847 UR - http://www.ncbi.nlm.nih.gov/pubmed/34715914 SN - 1758-2946 N1 - J.J.J.v.d.H. acknowledges funding from an ASDI eScience grant, ASDI.2017.030, from the Netherlands eScience Center. VL - 13 IS - 1 PB - Cold Spring Harbor Laboratory ER - TY - JOUR A1 - Zimmermann, Peter A1 - Neumann, Anna A1 - Çelik, Fatma A1 - Kindler, Heinz T1 - Sexuelle Gewalt gegen Kinder in Familien - Ein Forschungsüberblick JF - Sexuologie. Zeitschrift für Sexualmedizin, Sexualtherapie und Sexualwissenschaft Y1 - 2011 U6 - https://doi.org/10.61387/S.2011.34.16 SN - 0944-7105 VL - 18 IS - 34 SP - 119 EP - 142 PB - Deutsche Gesellschaft für Sexualmedizin, Sexualtherapie und Sexualwissenschaft ER - TY - JOUR A1 - Kernebeck, Sven A1 - Holle, Daniela A1 - Pogscheba, Patrick A1 - Jordan, Felix A1 - Mertl, Fabian A1 - Huldtgren, Alina A1 - Bader, Sebastian A1 - Kirste, Thomas A1 - Teipel, Stefan A1 - Holle, Bernhard A1 - Halek, Margareta T1 - A Tablet App- and Sensor-Based Assistive Technology Intervention for Informal Caregivers to Manage the Challenging Behavior of People With Dementia (the insideDEM Study): Protocol for a Feasibility Study JF - JMIR research protocols Y1 - 2019 U6 - https://doi.org/10.2196/11630 VL - 8 IS - 2 PB - JMIR ER - TY - JOUR A1 - Preciado López, Magdalena A1 - Huber, Florian A1 - Grigoriev, Ilya A1 - Steinmetz, Michel O. A1 - Akhmanova, Anna A1 - Koenderink, Gijsje H. A1 - Dogterom, Marileen T1 - Actin-microtubule coordination at growing microtubule ends JF - Nature Communications N2 - To power dynamic processes in cells, the actin and microtubule cytoskeletons organize into complex structures. Although it is known that cytoskeletal coordination is vital for cell function, the mechanisms by which cross-linking proteins coordinate actin and microtubule activities remain poorly understood. In particular, it is unknown how the distinct mechanical properties of different actin architectures modulate the outcome of actin-microtubule interactions. To address this question, we engineered the protein TipAct, which links growing microtubule ends via end-binding proteins to actin filaments. We show that growing microtubules can be captured and guided by stiff actin bundles, leading to global actin-microtubule alignment. Conversely, growing microtubule ends can transport, stretch and bundle individual actin filaments, thereby globally defining actin filament organization. Our results provide a physical basis to understand actin-microtubule cross-talk, and reveal that a simple cross-linker can enable a mechanical feedback between actin and microtubule organization that is relevant to diverse biological contexts. KW - DOAJ Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-34878 SN - 2041-1723 VL - 5 PB - Springer Nature ER - TY - JOUR A1 - Huber, Florian A1 - Ridder, Lars A1 - Verhoeven, Stefan A1 - Spaaks, Jurriaan H. A1 - Diblen, Faruk A1 - Rogers, Simon A1 - van der Hooft, Justin J. J. T1 - Spec2Vec: Improved mass spectral similarity scoring through learning of structural relationships JF - PLOS Computational Biology N2 - Spectral similarity is used as a proxy for structural similarity in many tandem mass spectrometry (MS/MS) based metabolomics analyses such as library matching and molecular networking. Although weaknesses in the relationship between spectral similarity scores and the true structural similarities have been described, little development of alternative scores has been undertaken. Here, we introduce Spec2Vec, a novel spectral similarity score inspired by a natural language processing algorithm-Word2Vec. Spec2Vec learns fragmental relationships within a large set of spectral data to derive abstract spectral embeddings that can be used to assess spectral similarities. Using data derived from GNPS MS/MS libraries including spectra for nearly 13,000 unique molecules, we show how Spec2Vec scores correlate better with structural similarity than cosine-based scores. We demonstrate the advantages of Spec2Vec in library matching and molecular networking. Spec2Vec is computationally more scalable allowing structural analogue searches in large databases within seconds. Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-34687 UR - http://www.ncbi.nlm.nih.gov/pubmed/33591968 SN - 1553-7358 N1 - Data Availability Statement: The pre-processed, cleaned dataset with all positive ionization mode spectra can be downloaded from https://doi.org/10.5281/zenodo.3978118, the original raw data can be accessed from https://doi.org/10.5281/zenodo.3979010. Funding: J.J.J.v.d.H. acknowledges funding from an ASDI eScience grant, ASDI.2017.030, from the Netherlands eScience Center—NLeSC, www.esciencecenter.nl, The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. VL - 17 IS - 2 PB - Cold Spring Harbor Laboratory ER - TY - JOUR A1 - Hiesinger, Karolin A1 - Tophoven, Silke T1 - Job requirement level, work demands, and health: a prospective study among older workers JF - International Archives of Occupational and Environmental Health KW - Mediation KW - Mental health KW - Older workers KW - Physical health KW - Physical work demands KW - Psychosocial work demands Y1 - 2019 UR - https://rdcu.be/b5E30 U6 - https://doi.org/10.1007/s00420-019-01451-2 VL - 92 SP - 1139 EP - 1149 PB - Springer ER - TY - JOUR A1 - Hiesinger, Karolin A1 - Tophoven, Silke A1 - March, Stefanie T1 - Geschlechtsspezifische Verzerrungen bei der Erfassung von Depressivität JF - Prävention und Gesundheitsförderung KW - BDI-V KW - Befragungsmodus KW - Bevölkerungsumfragen KW - Depressivität KW - Geschlechtsspezifische Verzerrung Y1 - 2018 UR - https://rdcu.be/b5FXp U6 - https://doi.org/10.1007/s11553-017-0634-x VL - 13 IS - 3 SP - 211 EP - 217 PB - Springer ER -