TY - JOUR A1 - van Rießen, Anne A1 - Aghamiri, Kathrin A1 - Streck, Rebekka T1 - Einblicke in pandemische Alltage der Kinder- und Jugendhilfe oder: Was macht eigentlich 'gute' Soziale Arbeit aus? JF - Forum für Kinder- und Jugendarbeit Y1 - 2021 UR - https://www.kinder-undjugendarbeit.de/fileadmin/user_upload/FORUM_2021/Aghamiri_Streck_van_Riessen_FORUM_3-4-2021.pdf SN - 1434-4696 VL - 37 IS - 3/4 PB - Verb. Kinder- und Jugendarbeit Hamburg e.V. CY - Hamburg ER - TY - JOUR A1 - van Rießen, Anne A1 - Fehlau, Michael T1 - Sozialräumliche Analysemethoden im Kontext von Digitalisierung JF - Sozialraum.de Y1 - 2021 UR - https://www.sozialraum.de/sozialraeumliche-analyse-und-beteiligungsmethoden-im-kontext-von-digitalisierung.php SN - 1868-2596 VL - 2 IS - 13 ER - TY - JOUR A1 - Unterfrauner, Elisabeth A1 - Voigt, Christian A1 - Hofer, Margit T1 - The effect of maker and entrepreneurial education on self-efficacy and creativity JF - Entrepreneurship Education Y1 - 2021 U6 - https://doi.org/10.1007/s41959-021-00060-w SN - 2520-8152 VL - 4 IS - 4 SP - 403 EP - 424 PB - Springer Nature ER - TY - JOUR A1 - Seebacher, Lisa M. A1 - Vana, Irina A1 - Voigt, Christian A1 - Tschank, Juliet T1 - Is Science for Everyone? Exploring Intersectional Inequalities in Connecting With Science JF - Frontiers in Education KW - DOAJ Y1 - 2021 UR - www.frontiersin.org/articles/10.3389/feduc.2021.673850/full#supplementary-material U6 - https://doi.org/10.3389/feduc.2021.673850 SN - 2504-284X N1 - The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/feduc.2021.673850/full#supplementary-material. Copyright © 2021 Seebacher, Vana, Voigt and Tschank. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms E-ISSN(s): VL - 6 PB - Frontiers ER - TY - JOUR A1 - Girod, Kai A1 - Lohmann, Heiko A1 - Kaluza, Stefan T1 - Methanol Synthesis with Steel Mill Gases: Performance Investigations in an On‐Site Technical Center JF - Chemie Ingenieur Technik KW - DEAL Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-34409 SN - 1522-2640 N1 - he investigations within the scope of the project Carbon2Chem® are funded by the German Federal Ministry of Education and Research (BMBF; support code: 03EK3039F). We also thank our project partners in the Carbon2Chem subproject L2 (methanol synthesis) for the trustful cooperation. Open access funding enabled and organized by Projekt DEAL. VL - 93 IS - 5 SP - 850 EP - 855 PB - Wiley ER - TY - JOUR A1 - Häusler, Alexander T1 - Erweiterung extrem rechten Resonazraums oder neue Form der „Delegitimierung des Staates“? Die Bewegung der Pandemie-Leugner*innen JF - DISS-Journal KW - Forena Y1 - 2021 UR - http://www.diss-duisburg.de/download/dissjournal-dl/DISS-Journal-41-2021.pdf SN - 2701-3081 IS - #41 SP - 14 EP - 17 PB - DISS ER - TY - JOUR A1 - Das, Sampad Gobinda A1 - Bhattacharyya, Suvanjan A1 - Chattopadhyay, Himadri A1 - Benim, Ali Cemal T1 - Transport Phenomenon of Simultaneously Developing Flow and Heat Transfer in Twisted Sinusoidal Wavy Microchannel under Pulsating Inlet Flow Condition JF - Heat Transfer Engineering Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-27697 SP - 1 EP - 14 PB - Taylor & Francis ER - TY - JOUR A1 - Funk, Lothar T1 - Collective good: the economics of pandemic policy JF - Wirtschaftsdienst KW - DOAJ Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-26875 SN - 1613-978X N1 - Open Access wird durch die ZBW — Leibniz-Informationszentrum Wirtschaft gefördert. VL - 101 IS - 1 PB - Springer Nature ER - TY - JOUR A1 - Kuske, Silke A1 - Borgmann, Sandra Olivia A1 - Wolf, Florian A1 - Bleck, Christian T1 - Emotional Safety in the Context of Dementia: A Multiperspective Qualitative Study JF - Journal of Alzheimer's disease KW - Alertness KW - attention KW - caffeine KW - cognition KW - learning KW - memory KW - mood, performance KW - peer Y1 - 2021 UR - http://www.ncbi.nlm.nih.gov/pubmed/33285639 U6 - https://doi.org/10.3233/jad-201110 VL - 79 IS - 1 SP - 355 EP - 375 PB - IOS ER - TY - JOUR A1 - Huber, Florian A1 - Ridder, Lars A1 - Verhoeven, Stefan A1 - Spaaks, Jurriaan H. A1 - Diblen, Faruk A1 - Rogers, Simon A1 - van der Hooft, Justin J. J. T1 - Spec2Vec: Improved mass spectral similarity scoring through learning of structural relationships JF - PLOS Computational Biology N2 - Spectral similarity is used as a proxy for structural similarity in many tandem mass spectrometry (MS/MS) based metabolomics analyses such as library matching and molecular networking. Although weaknesses in the relationship between spectral similarity scores and the true structural similarities have been described, little development of alternative scores has been undertaken. Here, we introduce Spec2Vec, a novel spectral similarity score inspired by a natural language processing algorithm-Word2Vec. Spec2Vec learns fragmental relationships within a large set of spectral data to derive abstract spectral embeddings that can be used to assess spectral similarities. Using data derived from GNPS MS/MS libraries including spectra for nearly 13,000 unique molecules, we show how Spec2Vec scores correlate better with structural similarity than cosine-based scores. We demonstrate the advantages of Spec2Vec in library matching and molecular networking. Spec2Vec is computationally more scalable allowing structural analogue searches in large databases within seconds. Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-34687 UR - http://www.ncbi.nlm.nih.gov/pubmed/33591968 SN - 1553-7358 N1 - Data Availability Statement: The pre-processed, cleaned dataset with all positive ionization mode spectra can be downloaded from https://doi.org/10.5281/zenodo.3978118, the original raw data can be accessed from https://doi.org/10.5281/zenodo.3979010. Funding: J.J.J.v.d.H. acknowledges funding from an ASDI eScience grant, ASDI.2017.030, from the Netherlands eScience Center—NLeSC, www.esciencecenter.nl, The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. VL - 17 IS - 2 PB - Cold Spring Harbor Laboratory ER - TY - JOUR A1 - Schorn, Michelle A. A1 - Verhoeven, Stefan A1 - Ridder, Lars A1 - Huber, Florian A1 - Acharya, Deepa D. A1 - Aksenov, Alexander A. A1 - Aleti, Gajender A1 - Moghaddam, Jamshid Amiri A1 - Aron, Allegra T. A1 - Aziz, Saefuddin A1 - Bauermeister, Anelize A1 - Bauman, Katherine D. A1 - Baunach, Martin A1 - Beemelmanns, Christine A1 - Beman, J. Michael A1 - Berlanga-Clavero, María Victoria A1 - Blacutt, Alex A. A1 - Bode, Helge B. A1 - Boullie, Anne A1 - Brejnrod, Asker A1 - Bugni, Tim S. A1 - Calteau, Alexandra A1 - Cao, Liu A1 - Carrión, Víctor J. A1 - Castelo-Branco, Raquel A1 - Chanana, Shaurya A1 - Chase, Alexander B. A1 - Chevrette, Marc G. A1 - Costa-Lotufo, Leticia V. A1 - Crawford, Jason M. A1 - Currie, Cameron R. A1 - Cuypers, Bart A1 - Dang, Tam A1 - de Rond, Tristan A1 - Demko, Alyssa M. A1 - Dittmann, Elke A1 - Du, Chao A1 - Drozd, Christopher A1 - Dujardin, Jean-Claude A1 - Dutton, Rachel J. A1 - Edlund, Anna A1 - Fewer, David P. A1 - Garg, Neha A1 - Gauglitz, Julia M. A1 - Gentry, Emily C. A1 - Gerwick, Lena A1 - Glukhov, Evgenia A1 - Gross, Harald A1 - Gugger, Muriel A1 - Guillén Matus, Dulce G. A1 - Helfrich, Eric J. N. A1 - Hempel, Benjamin-Florian A1 - Hur, Jae-Seoun A1 - Iorio, Marianna A1 - Jensen, Paul R. A1 - Kang, Kyo Bin A1 - Kaysser, Leonard A1 - Kelleher, Neil L. A1 - Kim, Chung Sub A1 - Kim, Ki Hyun A1 - Koester, Irina A1 - König, Gabriele M. A1 - Leao, Tiago A1 - Lee, Seoung Rak A1 - Lee, Yi-Yuan A1 - Li, Xuanji A1 - Little, Jessica C. A1 - Maloney, Katherine N. A1 - Männle, Daniel A1 - Martin H, Christian A1 - McAvoy, Andrew C. A1 - Metcalf, Willam W. A1 - Mohimani, Hosein A1 - Molina-Santiago, Carlos A1 - Moore, Bradley S. A1 - Mullowney, Michael W. A1 - Muskat, Mitchell A1 - Nothias, Louis-Félix A1 - O'Neill, Ellis C. A1 - Parkinson, Elizabeth I. A1 - Petras, Daniel A1 - Piel, Jörn A1 - Pierce, Emily C. A1 - Pires, Karine A1 - Reher, Raphael A1 - Romero, Diego A1 - Roper, M. Caroline A1 - Rust, Michael A1 - Saad, Hamada A1 - Saenz, Carmen A1 - Sanchez, Laura M. A1 - Sørensen, Søren Johannes A1 - Sosio, Margherita A1 - Süssmuth, Roderich D. A1 - Sweeney, Douglas A1 - Tahlan, Kapil A1 - Thomson, Regan J. A1 - Tobias, Nicholas J. A1 - Trindade-Silva, Amaro E. A1 - van Wezel, Gilles P. A1 - Wang, Mingxun A1 - Weldon, Kelly C. A1 - Zhang, Fan A1 - Ziemert, Nadine A1 - Duncan, Katherine R. A1 - Crüsemann, Max A1 - Rogers, Simon A1 - Dorrestein, Pieter C. A1 - Medema, Marnix H. A1 - van der Hooft, Justin J. J. T1 - A community resource for paired genomic and metabolomic data mining JF - Nature Chemical Biology Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-34708 UR - http://www.ncbi.nlm.nih.gov/pubmed/33589842 SN - 1552-4469 N1 - Additional information: Supplementary information The online version contains supplementary material available at https://doi.org/10.1038/s41589-020-00724-z. VL - 17 IS - 4 SP - 363 EP - 368 PB - Nature ER - TY - JOUR A1 - Beniddir, Mehdi A. A1 - Kang, Kyo Bin A1 - Genta-Jouve, Grégory A1 - Huber, Florian A1 - Rogers, Simon A1 - van der Hooft, Justin J. J. T1 - Advances in decomposing complex metabolite mixtures using substructure- and network-based computational metabolomics approaches JF - Natural Product Reports Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-34772 SN - 1460-4752 VL - 38 IS - 11 SP - 1967 EP - 1993 PB - The Royal Society of Chemistry ER - TY - JOUR A1 - Krebs, Christian A1 - Müller, Patrick A1 - Braun, Alexander T1 - Impact of Windshield Optical Aberrations on Visual Range Camera Based Classification Tasks Performed by CNNs JF - London Imaging Meeting Y1 - 2021 SN - 0-89208-346-6 U6 - https://doi.org/10.2352/issn.2694-118X.2021.LIM-83 SN - 2694-118X VL - 2021 IS - 1 SP - 83 EP - 87 PB - Ingenta connect ER - TY - JOUR A1 - Falling, Luisa A1 - Kaluza, Stefan A1 - Strucks, Peter T1 - A Short Review on Ni-Catalyzed Methanation of CO²: Reaction Mechanism, Catalyst Deactivation, Dynamic Operation JF - Chemie Ingenieur Technik N2 - Today, the use of renewable energies and recycling of climate-changing gases are increasingly important. In this context,coupling of methanation with small, decentralized CO2sources such as biogas plants provides one possibility. However,fluctuating availability of renewables for hydrogen production in combination with small storage volumes result in anenhanced demand for dynamic process operation. This leads to new research challenges with respect to the required cata-lysts and the overall process design. To draw reliable conclusions about the catalytic performance under dynamic processoperation, the mechanism of the methanation reaction as well as typical deactivation procedures of the catalyst appliedunder steady-state conditions have to be reviewed thoroughly. KW - Power-to-gas KW - Ni catalysts KW - Dynamic operation KW - Deactivation KW - CO2Methanation Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-32134 SN - 1522-2640 VL - 93 SP - 1526 EP - 1536 PB - Wiley ER - TY - JOUR A1 - Benim, Ali Cemal A1 - Canal, Cansu Deniz A1 - Boke, Yakup Erhan T1 - A Validation Study for RANS Based Modelling of Swirling Pulverized Fuel Flames JF - Energies N2 - A swirling pulverized coal flame is computationally investigated. A Eulerian–Lagrangian formulation is used to describe the two-phase flow. Turbulence is modelled within a RANS (Reynolds averaged numerical simulation) framework. Four turbulence viscosity- (TV) based models, namely the standard k-ε model, realizable k-ε model, renormalization group theory k-ε model, and the shear stress transport k-ω model are used. In addition, a Reynolds stress transport model (RSM) is employed. The models are assessed by comparing the predicted velocity fields with the measurements of other authors. In terms of overall average values, the agreement of the predictions to the measurements is observed to be within the range 20–40%. A better performance of the RSM compared to the TV models is observed, with a nearly twice as better overall agreement to the experiments, particularly for the swirl velocity. In the second part of the investigation, the resolution of the discrete particle phase in modelling the turbulent particle dispersion (TPD) and particle size distribution (SD) is investigated. Using the discrete random walk model for the TPD, it is shown that even five random walks are sufficient for an accuracy that is quite high, with a less than 1% mean deviation from the solution obtained by thirty random walks. The approximation of the measured SD is determined by a continuous Rosin–Rammler distribution function, and inaccuracies that can occur in its subsequent discretization are demonstrated and discussed. An investigation on the resolution of the SD by discrete particle size classes (SC) indicates that 12 SC are required for an accuracy with a less than 1% mean deviation from the solution with 18 SC. Although these numbers may not necessarily be claimed to be sufficiently universal, they may serve as guidance, at least for SD with similar characteristics KW - DOAJ Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-37365 SN - 1996-1073 VL - 14 IS - 21 PB - MDPI ER - TY - JOUR A1 - Strucks, Peter A1 - Watermann, Clara A1 - Weber, Konradin A1 - Kaluza, Stefan T1 - Systematic Investigations of Vibrational and Fluid‐Mechanical Stability of Coated Monolithic Catalysts JF - Chemie Ingenieur Technik N2 - Heterogeneous catalysts usually consist of porous, inorganic materials. Especially in the mobile application, e.g., in exhaust gas catalysis as a part of the gas line of an engine, there are loads due to vibrations and high gas velocities. It can be assumed that physical stress will lead to a loss of the catalytically active coating. The present contribution describes experimental setups and methods for a systematic and reproducible investigation of the main influences to the mass loss due to vibrational and fluid‐mechanical stress caused by particle‐free gas flows. KW - Design of experiments KW - Extruded catalysts KW - Mechanical stability Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-28930 SN - 1522-2640 VL - 93 IS - 5 SP - 1 EP - 6 PB - Wiley ER - TY - JOUR A1 - Nyssen Guillén, Viola Isabel A1 - Deckert, Carsten T1 - Cultural influence on innovativeness - links between “The Culture Map” and the “Global Innovation Index” JF - International Journal of Corporate Social Responsibility KW - culture KW - culture dimensions KW - Innovativeness KW - DOAJ Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-29121 SN - 2366-0074 VL - 6 IS - 1 PB - Springer Nature ER - TY - JOUR A1 - Deckert, Carsten A1 - Niemann, Jörg T1 - Management des Innovationsportfolios: Portfolio-Matrizen zumManagement von Innovationsprojekten JF - WiSt - Wirtschaftswissenschaftliches Studium Y1 - 2021 U6 - https://doi.org/10.15358/0340-1650-2021-11-59 VL - 50 IS - 11 SP - 59 EP - 64 PB - Beck ER - TY - JOUR A1 - Pfeiffelmann, Björn A1 - Benim, Ali Cemal A1 - Joos, Franz T1 - Water-Cooled Thermoelectric Generators for Improved Net Output Power: A Review JF - Energies N2 - Thermoelectric generators (TEGs) have the ability to convert waste heat into electrical energy under unfavorable conditions and are becoming increasingly popular in academia, but have not yet achieved a broad commercial success, due to the still comparably low efficiency. To increase the efficiency and economic viability of TEGs, research is performed on the materials on one hand and on the system connection on the other. In the latter case, the net output power of the cooling system plays a key role. At first glance, passive cooling seems preferable to active cooling because it does not affect the net electrical output power. However, as shown in the present review, the active cooling is to be preferred for net output power. The situation is similar in air and water-cooling. Even though air-cooling is easier to set up, the water-cooling should be preferred to achieve higher net output power. It is shown that microchannel cooling has similar hydraulic performance to conventional cooling and inserts increase the net output power of TEG. As the review reveals that active water-cooling should be the method of choice to achieve high net output power, it also shows that a careful optimization is necessary to exploit the potential. KW - Energy Engineering and Power Technology KW - Renewable Energy, Sustainability and the Environment KW - Electrical and Electronic Engineering KW - Control and Optimization KW - DOAJ Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-37323 SN - 1996-1073 VL - 14 IS - 24 PB - MDPI ER - TY - JOUR A1 - Virchow, Fabian T1 - Einschüchtern und Vertreiben, Bestrafen und Eskalieren. Instrumentelle Zielsetzungen rechtsterroristischen Handelns JF - Soziale Probleme N2 - Der Beitrag entwickelt anhand zahlreicher Beispiele rechtsterroristischer Gewalt eine Systematisierung instrumenteller Zielsetzungen rechtsterroristischen Handelns. Dabei ruft er zunächst als zentrale weltanschauliche Referenz den völkischen Nationalismus auf, dem biopolitische Paradigmen inhärent sind, denen mittels rechtsterroristischer Gewalt Geltung verschafft werden soll. Dieses ist für eine Vielzahl rechtsterroristischer Gewalttaten zentral, denen es um die Aufrechterhaltung rassistischer, sexistischer und heteronormativer Gesellschaftsverhältnisse geht. Regelmäßig ist solche Gewalt auch als Botschaftsverbrechen zu verstehen, wobei ganz unterschiedliche Modi der Kommunikation beobachtbar sind. Rechtsterroristische Gewalt – sofern sie nicht parastaatlich verfasst ist – hat nicht die direkte Schwächung der Kampffähigkeit des Gegners zum Ziel, sondern zielt auf Bestrafung, Einschüchterung und Vertreibung ausgewählter sozialer Gruppen und Individuen sowie in manchen Fällen auf das strategische Moment der Zuspitzung gesellschaftlicher Konflikte, wie im abschließenden Teil des Beitrages an zahlreichen Beispielen gezeigt wird. Y1 - 2021 U6 - https://doi.org/10.1007/s41059-021-00086-1 SN - 0939-608X VL - 32 IS - 2 SP - 131 EP - 149 PB - Springer Nature ER - TY - JOUR A1 - Benim, Ali Cemal T1 - Numerical Calculation of Sink Velocities for Helminth Eggs in Water JF - Computation N2 - The settling velocities of helminth eggs of three types, namely Ascaris suum (ASC), Trichuris suis (TRI), and Oesophagostomum spp. (OES), in clean tap water are computationally determined by means of computational fluid dynamics, using the general-purpose CFD software ANSYS Fluent 18.0. The previous measurements of other authors are taken as the basis for the problem formulation and validation, whereby the latter is performed by comparing the predicted sink velocities with those measured in an Owen tube. To enable a computational treatment, the measured shapes of the eggs are parametrized by idealizing them in terms of elementary geometric forms. As the egg shapes show a variation within each class, “mean” shapes are considered. The sink velocities are obtained through the computationally obtained drag coefficients. The latter are defined by means of steady-state calculations. Predicted sink velocities are compared with the measured ones. It is observed that the calculated values show a better agreement with the measurements, for ASC and TRI, compared to the theoretical sink values delivered by the Stokes theory. However, the observed agreement is still found not to be very satisfactory, indicating the role of further parameters, such as the uncertainties in the characterization of egg shapes or flocculation effects even in clean tap water. KW - Applied Mathematics KW - Modeling and Simulation KW - General Computer Science KW - Theoretical Computer Science KW - DOAJ Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-37318 SN - 2079-3197 VL - 9 IS - 12 PB - MDPI ER - TY - JOUR A1 - Reims, Nancy A1 - Tophoven, Silke T1 - Double Burden of Disability and Poverty: Does Vocational Rehabilitation Ease the School–to–Work Transition? JF - Social Inclusion N2 - Poor young people more often face health difficulties, (learning) disabilities, and are overrepresented in special schools. Consequently, youth from poor households disproportionately frequently participate in disability‐specific programs aiming to improve their educational levels and labor market opportunities. They face a double burden of disability and poverty. In our study, we look at poor and non‐poor youth with disabilities (YPWD) who participate in vocational rehabilitation (VR) and whether VR helps them (a) in transitioning into employment and (b) in leaving poverty. We examine the association between the receipt of initial basic income support (BIS) as a poverty indicator, later labor market outcomes, and earned vocational qualification using administrative data. We make use of a sample of all persons accepted for VR in 2010 (N = 36,645). We employ logit models on VR attendees’ labor market outcomes three and five years after being accepted for VR as well as on their earned vocational qualifications. Beside initial poverty status, we control for educational level, type, and degree of disability and program pattern during the VR process. Our findings show that YPWD from poor households have a decreased likelihood of a vocational certificate and employment. Additionally, they are more likely to receive BIS than young people not from poor households and thus more likely to remain poor. In conclusion, VR seems to support poor YPWD less in their school‐to‐work transitions. Thus, disability‐specific programs should be more tailored to the social situations of participants, and counsellors should be more sensitive to their social backgrounds. KW - DOAJ KW - youth KW - vocational rehabilitation KW - labor market integration KW - school‐to‐work transition KW - germany KW - basic income support Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-40131 SN - 2183-2803 N1 - This article is part of the issue “Promoting Inclusion and Equality in Education” edited Allen Thurston (Queen’s University Belfast, UK) and Tien‐Hui Chiang (Anhui Normal University, China). VL - 9 IS - 4 SP - 92 EP - 102 PB - Cogitatio ER - TY - JOUR A1 - Huber, Florian A1 - van der Burg, Sven A1 - van der Hooft, Justin J. J. A1 - Ridder, Lars T1 - MS2DeepScore: a novel deep learning similarity measure to compare tandem mass spectra JF - Journal of Cheminformatics N2 - Mass spectrometry data is one of the key sources of information in many workflows in medicine and across the life sciences. Mass fragmentation spectra are generally considered to be characteristic signatures of the chemical compound they originate from, yet the chemical structure itself usually cannot be easily deduced from the spectrum. Often, spectral similarity measures are used as a proxy for structural similarity but this approach is strongly limited by a generally poor correlation between both metrics. Here, we propose MS2DeepScore: a novel Siamese neural network to predict the structural similarity between two chemical structures solely based on their MS/MS fragmentation spectra. Using a cleaned dataset of > 100,000 mass spectra of about 15,000 unique known compounds, we trained MS2DeepScore to predict structural similarity scores for spectrum pairs with high accuracy. In addition, sampling different model varieties through Monte-Carlo Dropout is used to further improve the predictions and assess the model's prediction uncertainty. On 3600 spectra of 500 unseen compounds, MS2DeepScore is able to identify highly-reliable structural matches and to predict Tanimoto scores for pairs of molecules based on their fragment spectra with a root mean squared error of about 0.15. Furthermore, the prediction uncertainty estimate can be used to select a subset of predictions with a root mean squared error of about 0.1. Furthermore, we demonstrate that MS2DeepScore outperforms classical spectral similarity measures in retrieving chemically related compound pairs from large mass spectral datasets, thereby illustrating its potential for spectral library matching. Finally, MS2DeepScore can also be used to create chemically meaningful mass spectral embeddings that could be used to cluster large numbers of spectra. Added to the recently introduced unsupervised Spec2Vec metric, we believe that machine learning-supported mass spectral similarity measures have great potential for a range of metabolomics data processing pipelines. KW - DOAJ Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-34847 UR - http://www.ncbi.nlm.nih.gov/pubmed/34715914 SN - 1758-2946 N1 - J.J.J.v.d.H. acknowledges funding from an ASDI eScience grant, ASDI.2017.030, from the Netherlands eScience Center. VL - 13 IS - 1 PB - Cold Spring Harbor Laboratory ER - TY - JOUR A1 - Steffens, Jochen A1 - Wilczek, Tobias A1 - Weinzierl, Stefan T1 - Junk Food or Haute Cuisine to the Ear? – Investigating the Relationship Between Room Acoustics, Soundscape, Non-Acoustical Factors, and the Perceived Quality of Restaurants JF - Frontiers in Built Environment N2 - Sound and music are well-studied aspects of the quality of experience in restaurants; the role of the room acoustical conditions, their influence on the visitors’ soundscape evaluation and their impact on the overall customer satisfaction in restaurants, however, has received less scientific attention. The present field study therefore investigated whether sound pressure level, reverberation time, and soundscape pleasantness can predict factors associated with overall restaurant quality. In total, 142 persons visiting 12 restaurants in Berlin rated relevant acoustical and non-acoustical factors associated with restaurant quality. Simultaneously, the A-weighted sound pressure level (LA,eq,15) was measured, and the reverberation time in the occupied state (T20,occ) was obtained by measurements performed in the unoccupied room and a subsequent calculation of the occupied condition according to DIN 18041. Results from linear mixed-effects models revealed that both the LA,eq,15 and T20,occ had a significant influence on soundscape pleasantness and eventfulness, whereby the effect of T20,occ was meditated by the LA,eq,15. Also, the LA,eq,15 as well as soundscape pleasantness were significant predictors of overall restaurant quality. A comprehensive structural equation model including both acoustical and non-acoustical factors, however, indicates that the effect of soundscape pleasantness on overall restaurant quality is mediated by the restaurant’s atmosphere. Our results support and extend previous findings which suggest that the acoustical design of restaurants involves a trade-off between comfort and liveliness, depending on the desired character of the place. KW - DOAJ Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-32115 SN - 2297-3362 N1 - The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fbuil.2021.676009/full#supplementary-material; ut:000655121500001 VL - 676009 PB - Frontiers ER - TY - JOUR A1 - Niemann, Joerg A1 - Fussenecker, Claudia A1 - Schloesser, Martin A1 - Ocakci, Elif T1 - THE WORKERS PERSPECTIVE - EYE TRACKING IN PRODUCTION ENVIRONMENTS JF - ACTA TECHNICA NAPOCENSIS SERIES-APPLIED MATHEMATICS MECHANICS AND ENGINEERING Y1 - 2021 SN - 1221-5872 VL - 64 IS - 1 SP - 7 EP - 14 PB - Technical University of Cluj-Napoca ER - TY - JOUR A1 - Jacobs, Naomi A1 - Huldtgren, Alina T1 - Why value sensitive design needs ethical commitments JF - Ethics and Information Technology KW - Applied ethics KW - Ethical theory KW - Ethics KW - Technology KW - Value sensitive design Y1 - 2021 U6 - https://doi.org/10.1007/s10676-018-9467-3 SN - 1572-8439 VL - 23 IS - 1 SP - 23 EP - 26 PB - Springer Nature ER - TY - JOUR A1 - Müller, Patrick A1 - Brummel, Mattis A1 - Braun, Alexander T1 - Spatial recall index for machine learning algorithms JF - London Imaging Meeting N2 - We present a novel metric Spatial Recall Index to assess the performance of machine-learning (ML) algorithms for automotive applications, focusing on where in the image which performance occurs. Typical metrics like intersection-over-union (IoU), precisionrecallcurves or average precision (AP) quantify the performance over a whole database of images, neglecting spatial performance variations. But as the optics of camera systems are spatially variable over the field of view, the performance of ML-based algorithms is also a function of space, which we show in simulation: A realistic objective lens based on a Cooke-triplet that exhibits typical optical aberrations like astigmatism and chromatic aberration, all variable over field, is modeled. The model is then applied to a subset of the BDD100k dataset with spatially-varying kernels. We then quantify local changes in the performance of the pre-trained Mask R-CNN algorithm. Our examples demonstrate the spatial dependence of the performance of ML-based algorithms from the optical quality over field, highlighting the need to take the spatial dimension into account when training ML-based algorithms, especially when looking forward to autonomous driving applications. Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-35657 SN - 0-89208-346-6 VL - 2021 IS - 1 SP - 58 EP - 62 PB - Society for Imaging Science and Technology ER - TY - JOUR A1 - Wittpahl, Christian A1 - Deegan, Brian A1 - Black, Bob A1 - Braun, Alexander T1 - An analytic-numerical image flicker study to test novel flicker metrics JF - Electronic Imaging: Society for Imaging Science and Technology Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-35671 SN - 2470-1173 IS - 17 SP - 1 EP - 8 PB - Society for Imaging Science and Technology ER - TY - JOUR A1 - Rakow, Thomas C. A1 - Faeskorn-Woyke, Heode A1 - Saatz, Inga Marina A1 - Knolle, Harm T1 - Es EILD – Anforderungen an die Publikation freier Lerneinheiten (OER) im Fach Datenbanken JF - Datenbank-Spektrum N2 - Kompetenzen auf dem Gebiet der Datenbanken gehören zum Pflichtbereich der Informatik. Das Angebot an Lehrbüchern, Vorlesungsformaten und Tools lässt sich jedoch für Lehrende oft nur eingeschränkt in die eigene Lehre integrieren. In diesem Aufsatz schildern wir unsere Erfahrungen in der Nutzung (frei) verfügbarer und der Entwicklung eigener digitaler Inhalte für grundlegende Datenbankveranstaltungen. Die Präferenzen der Studierenden werden mittels Nutzungsanalysen und Befragungen ermittelt. Wir stellen die Anforderungen auf, wie die nicht selten aufwendig herzustellenden digitalen Materialien von Lehrenden in ihre Lehr- und Lernumgebungen integriert werden können. Als konstruktive Antwort auf diese Herausforderung wird das Konzept EILD zur Entwicklung von Inhalten für die Lehre im Fach Datenbanken vorgestellt. Die Inhalte sollen in vielfältigen Lernszenarien eingesetzt werden können und mit einer Creative Commons (CC) Lizenzierung als OER (open educational resources) frei zur Verfügung stehen. KW - Hochschullehre KW - Datenbanksystem KW - Open educational Resources KW - OER KW - Creative Commons KW - EILD.nrw Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-28947 SN - 1610-1995 N1 - Mitarbeiter der Autoren arbeiten in dem Projekt EILD.nrw, das durch das Land Nordrhein-Westfalen in einem Kooperationsvorhaben der Digitalen Hochschule NRW (DH.NRW) gefördert wird. Dieser Artikel ist ein Beitrag zu dem Schwerpunktthema „Digitale Lehre im Fachgebiet Datenbanksysteme“. Weitere Beiträge zum Thema sind im Datenbank-Spektrum in den Heften 21(1) und 21(2) von März bzw. Juli 2021 enthalten. Heft 21(1): https://link.springer.com/journal/13222/volumes-and-issues/21-1 Heft 21(2): https://link.springer.com/journal/13222/volumes-and-issues/21-2 VL - 2 IS - 12 SP - 1 EP - 10 PB - Springer Nature ER -