TY - JOUR A1 - Benim, Ali Cemal A1 - Gül, Fethi A1 - Assmann, Alexander A1 - Akhyari, Payam A1 - Lichtenberg, Artur A1 - Joos, Franz T1 - Validation of loss-coefficient-based outlet boundary conditions for simulating aortic flow JF - Journal of Mechanics in Medicine and Biology Y1 - 2016 U6 - https://doi.org/10.1142/s0219519416500111 VL - 16 IS - 2 PB - World Scientific ER - TY - JOUR A1 - Benim, Ali Cemal A1 - Frank, Thiemo A1 - Assmann, Alexander A1 - Lichtenberg, Artur A1 - Akhyari, Payam T1 - Computational investigation of hemodynamics in hardshell venous reservoirs: A comparative study JF - Artificial Organs N2 - Extracorporeal circulation using heart‐lung‐machines is associated with a profound activation of corpuscular and plasmatic components of circulating blood, which can also lead to deleterious events such as systemic inflammatory response and hemolysis. Individual components used to install the extracorporeal circulation have an impact on the level of activation, most predominantly membrane oxygenators and hardshell venous reservoirs as used in extracorporeal systems. The blood flows in two different hardshell reservoirs are computationally investigated. A special emphasis is placed on the prediction of an onset of transition and turbulence generation. Reynolds‐averaged numerical simulations (RANS) based on a transitional turbulence model, as well as large eddy simulations (LES) are applied to achieve an accurate prediction. In the LES analysis, the non‐Newtonian behavior of the blood is considered via the Carreau model. Blood damage potential is quantified applying the Modified Index of Hemolysis (MIH) based on the predicted flow fields. The results indicate that the flows in both reservoirs remain predominantly laminar. For one of the reservoirs, considerable turbulence generation is observed near the exit site, caused by the specific design for the connection with the drainage tube. This difference causes the MIH of this reservoir to be nearly twice as large as compared to the alternative design. However, a substantial improvement of these performance criteria can be expected by a local geometry modification. Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-29070 SN - 1525-1594 VL - 44 IS - 4 SP - 411 EP - 418 PB - Wiley ER -