TY - JOUR A1 - Stuhrmann, Björn A1 - Huber, Florian A1 - Käs, Josef T1 - Robust organizational principles of protrusive biopolymer networks in migrating living cells JF - Plos One N2 - Cell migration is associated with the dynamic protrusion of a thin actin-based cytoskeletal extension at the cell front, which has been shown to consist of two different substructures, the leading lamellipodium and the subsequent lamellum. While the formation of the lamellipodium is increasingly well understood, organizational principles underlying the emergence of the lamellum are just beginning to be unraveled. We report here on a 1D mathematical model which describes the reaction-diffusion processes of a polarized actin network in steady state, and reproduces essential characteristics of the lamellipodium-lamellum system. We observe a steep gradient in filament lengths at the protruding edge, a local depolymerization maximum a few microns behind the edge, as well as a differential dominance of the network destabilizer ADF/cofilin and the stabilizer tropomyosin. We identify simple and robust organizational principles giving rise to the derived network characteristics, uncoupled from the specifics of any molecular implementation, and thus plausibly valid across cell types. An analysis of network length dependence on physico-chemical system parameters implies that to limit array treadmilling to cellular dimensions, network growth has to be truncated by mechanisms other than aging-induced depolymerization, e.g., by myosin-associated network dissociation at the transition to the cell body. Our work contributes to the analytical understanding of the cytoskeletal extension's bisection into lamellipodium and lamellum and sheds light on how cells organize their molecular machinery to achieve motility. KW - DOAJ Y1 - 2011 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:due62-opus-34901 SN - 1932-6203 N1 - Funding: This work has been supported by the Leipzig Graduate College ‘‘GK 1097 InterNeuro - Interdisciplinary Approaches in Cellular Neuroscience’’ (http:// www.uni-leipzig.de/˜ineuro/) and the Graduate School ‘‘Leipzig School of Natural Sciences - Building with Molecules and Nano-objects (BuildMoNa)’’ (http://www. buildmona.de/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. VL - 6 IS - 1 PB - Public Library of Science (PLoS) ER - TY - JOUR A1 - Johanning, M. A1 - Braun, Alexander A1 - Eiteneuer, D. A1 - Paape, C. A1 - Balzer, C. A1 - Neuhauser, W. A1 - Wunderlich, C. T1 - Resonance-enhanced isotope-selective photoionization of YbI for ion trap loading JF - Applied Physics B Y1 - 2011 UR - https://arxiv.org/pdf/0712.0969.pdf U6 - https://doi.org/10.1007/s00340-011-4502-7 SN - 1432-0649 VL - 103 IS - 2 SP - 327 EP - 338 PB - Springer Nature ER - TY - GEN ED - Khabyuk, Olexiy ED - Kops, Manfred T1 - Public Service Broadcasting: A German-Ukrainian Exchange of Opinions Y1 - 2011 SN - 978-3-643-80094-7 VL - Kölner Schriften zur Medienökonomie PB - Lit-Verlag CY - Berlin ER - TY - CHAP A1 - Steffens, Jochen A1 - Küppers, Thomas A1 - Skoda, Sabrina T1 - Psychologische Einflussfaktoren bei der Beurteilung des Innengeräusches von Elektrofahrzeugen T2 - 5. DEGA-Symposium "E-Mobilität & Akustik": 21. Oktober 2011, Stuttgart Y1 - 2011 CY - Stuttgart ER - TY - JOUR A1 - Steffens, Jochen A1 - Küppers, Thomas A1 - Skoda, Sabrina T1 - Psychological factors influencing the evaluation of electric vehicle interior noise JF - Journal of the Acoustical Society of America N2 - Increasing global awareness of the benefits of electromobility has brought about the need for new concepts in terms of the acoustic design of future vehicle generations. This includes both the creative design process and the development of suitable methods for the evaluation of target sounds by trial participants. The main difference between e-car sound surveys and those carried out on familiar sound categories is the potential consumer’s lack of experience with electric vehicles. Thus the consumer has no, or very unspecific, expectations in this regard. Several studies have consequently shown that many subjects have to construct their personal frame of reference for evaluation within the listening experiment. However, this is possibly at odds with experience-based expectations relating to the sounds of conventional combustion engines. The result is a conflict of objectives between the traditional and the modern, familiarity and strangeness and not least between driving freedom and ecological awareness. In this context, the authenticity of the sound and the subjective interpretability of the sound information also appear as moderator variables. Moreover, associations with other vehicle categories, for example streetcars, also influence the perceived sound quality. In the course of this contribution, these factors will be expounded and their influence on the evaluation of interior noise discussed. KW - HB Y1 - 2011 U6 - https://doi.org/10.1121/1.3655176 VL - 130 IS - 4 PB - AIP ER - TY - CHAP A1 - Khabyuk, Olexiy ED - Khabyuk, Olexiy T1 - Protecting Public Service Broadcasting from State Intervention T2 - Public Service Broadcasting: A German-Ukrainian Exchange of Opinions Y1 - 2011 SN - 978-3-643-80094-7 SP - 67 EP - 74 PB - Lit-Verlag CY - Berlin ER - TY - CHAP A1 - Musall, Eike A1 - Voss, Karsten ED - Voss, Karsten ED - Musall, Eike T1 - Projekte und ihre Merkmale im Überblich - Teil 2 T2 - Nullenergiegebäude KW - Projektbeschreibung KW - Querschnittsauswertung Y1 - 2011 UR - https://www.degruyter.com/viewbooktoc/product/205283 SN - 978-3-920034-50-8 N1 - Zugriff via Campuslizenz SP - 114 EP - 119 PB - Detail, Institut für internationale Architektur-Dokumentation CY - München ER - TY - CHAP A1 - Musall, Eike A1 - Voss, Karsten ED - Voss, Karsten ED - Musall, Eike T1 - Projekte und ihre Merkmale im Überblich - Teil 1 T2 - Nullenergiegebäude KW - Projektbeschreibung KW - Querschnittsauswertung KW - Solarenergie KW - Sonnenschutz Y1 - 2011 SN - 978-3-920034-50-8 SP - 50 EP - 55 PB - Detail, Institut für internationale Architektur-Dokumentation CY - München ER - TY - CHAP A1 - Musall, Eike A1 - Voss, Karsten ED - Voss, Karsten ED - Musall, Eike T1 - Plusenergiesiedlung: Freiburg, D 2006 T2 - Nullenergiegebäude KW - Bilanzierung KW - Clusterung KW - Definitionsbeschreibung KW - Messdatenauswertung KW - Projektbeschreuibung KW - Solarenergie KW - Sonnenschutz KW - Verbrauchswerte Y1 - 2011 UR - https://www.degruyter.com/viewbooktoc/product/205283 SN - 978-3-920034-50-8 N1 - Zugriff via Campuslizenz SP - 94 EP - 99 PB - Detail, Institut für internationale Architektur-Dokumentation CY - München ER - TY - CHAP A1 - Zimmermann, Peter A1 - Çelik, Fatma A1 - Iwanski, Alexandra A1 - Mohr, C. A1 - Neumann, Anna ED - Renate, Walthes ED - Renate, Hinz T1 - Persönlichkeitsunterschiede und ihre Auswirkungen im schulischen Kontext T2 - Verschiedenheit als Diskurs Y1 - 2011 SN - 978-3-7720-8401-0 SP - 151 EP - 162 PB - Narr Francke Attempto CY - Tübingen ER -