@article{BayerPabst2018, author = {Bayer, Markus and Pabst, Andrea}, title = {Heroes and victims: economies of entitlement after violent pasts}, series = {Peacebuilding}, volume = {6}, journal = {Peacebuilding}, number = {1}, publisher = {Taylor \& Francis}, doi = {10.1080/21647259.2017.1303868}, pages = {49 -- 64}, year = {2018}, language = {en} } @article{DehmerNiemann2018, author = {Dehmer, Joanna and Niemann, J{\"o}rg}, title = {Value Chain Management Through Cloud-based Platforms}, series = {Procedia - Social and Behavioral Sciences}, volume = {238}, journal = {Procedia - Social and Behavioral Sciences}, publisher = {Elsevier}, doi = {10.1016/j.sbspro.2018.03.021}, pages = {177 -- 181}, year = {2018}, language = {en} } @article{BernhardtLeeser2017, author = {Bernhardt, Anne-Julchen and Leeser, J{\"o}rg}, title = {NEUBAU: Flexible Self-Build Cities in Germany}, series = {Architectural Design}, volume = {87}, journal = {Architectural Design}, number = {5}, publisher = {Wiley}, doi = {10.1002/ad.2213}, pages = {30 -- 37}, year = {2017}, language = {en} } @article{BhattacharyyaChattopadhyayGuinetal.2019, author = {Bhattacharyya, Suvanjan and Chattopadhyay, Himadri and Guin, Anindya and Benim, Ali Cemal}, title = {Investigation of Inclined Turbulators for Heat Transfer Enhancement in a Solar Air Heater}, series = {Heat Transfer Engineering}, volume = {40}, journal = {Heat Transfer Engineering}, number = {17/18}, publisher = {Taylor \& Francis}, doi = {10.1080/01457632.2018.1474593}, pages = {1451 -- 1460}, year = {2019}, language = {en} } @article{DeckertSchomaker2019, author = {Deckert, Carsten and Schomaker, Rahel M.}, title = {Cultural Impacts on National Innovativeness: Not Every Cultural Dimension Is Equal}, series = {Cross-Cultural Research}, volume = {53}, journal = {Cross-Cultural Research}, number = {2}, publisher = {sage journals}, doi = {10.1177/1069397118799700}, pages = {186 -- 214}, year = {2019}, language = {en} } @phdthesis{Eilert2013, author = {Eilert, Eva}, title = {New applications of heterologous gene expression in Hansenula polymorpha for protein and metabolite production}, publisher = {Institut f{\"u}r Molekulare Mykologie, Institut f{\"u}r Mikrobiologie}, address = {D{\"u}sseldorf}, organization = {Institut f{\"u}r Molekulare Mykologie, Institut f{\"u}r Mikrobiologie}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:061-20130527-092604-7}, year = {2013}, abstract = {The methylotrophic yeast Hansenula polymorpha has been established as a highly efficient expression system. Strong promoters derived from the methanol metabolism pathway and mitotically stable high-copy integration have made this organism very effective for heterologous protein expression. To improve the processing of secretory proteins targeted by the MFα prepro sequence, variations in the amino acid composition near the processing site of Kex2p were investigated (Manuscript I). The insertion of Ala-Pro between MFα prepro sequence and protein of interest leads to an improved processing of the signal sequence in case of interleukin-6 (IL-6) and interferon-α 2a (IFNα-2a). Modeling of the transition sequences confirmed a better exposition of the Kex2p-cleavage site in dependency of Ala-Pro insertions. Analysis of the secreted proteins revealed activity of an Ala-Pro specific endoprotease. Partial removal of the N-terminal Ala-Pro dipeptide was also detected during IFNα-2a processing. The putative protease responsible for the processing of Ala-Pro dipeptides was identified by gene deletion. Significant similarities with Saccharomyces cerevisiae Ste13p were identified. To generally improve productivity in the H. polymorpha system new fusion protein strategies were investigated (Manuscript II). The recombinantly strongly expressed cytosolic ferritin heavy chain (FTH1) was analyzed with regard to its potential as fusion partner for difficult-to-express target proteins. A fragment of the parathyroid hormone (PTH) was chosen to explore whether fusion to FTH1 enhances PTH stability. We could show that the expression level of this fusion protein was at least of the magnitude of that of FTH1 without fusion partner. The solubility of the fusion protein was increased in comparison to FTH1 alone and no degradation of PTH occurred when fused C-terminally to FTH1. Ectoine and 5-hydroxyectoine belong to the family of compatible solutes which are known to contribute to the adaptation of the cell to osmotic stress by mediation of a constant turgor. H. polymorpha was engineered to express the enzymes of the H. elongata 5-hydroxyectoine biosynthesis pathway (Manuscript III). Expression of the enzymes EctB, EctA, EctC and EctD in H. polymorpha resulted in production of 5-hydroxyectoine in gram per liter scale with almost full conversion of ectoine to 5-hydroxyectoine. We showed that 5-hydroxyectoine synthesis was influenced by feeding of methanol during cultivation. Furthermore, 5-hydroxyectoine synthesis was downregulated by the addition of methionine, lysine or threonine indicating the existence of a feedback regulated aspartate kinase in H. polymorpha.}, language = {en} } @article{TophovenReimsTisch2019, author = {Tophoven, Silke and Reims, Nancy and Tisch, Anita}, title = {Vocational Rehabilitation of Young Adults with Psychological Disabilities}, series = {Journal of Occupational Rehabilitation}, volume = {29}, journal = {Journal of Occupational Rehabilitation}, number = {1}, publisher = {Springer}, doi = {10.1007/s10926-018-9773-y}, pages = {150 -- 162}, year = {2019}, abstract = {Objective Vocational rehabilitation measures support youth and young adults with disabilities to obtain vocational training and to enter the labor market. In Germany, a growing number of young people with psychological disabilities in vocational rehabilitation can be observed. The study at hand focuses on this group and examines their (un-)unemployment biographies before vocational rehabilitation, their access to vocational rehabilitation and identifies their individual challenges within the process of vocational rehabilitation. Methods Using a multi-methods approach, we analyze representative administrative data of the German Federal Employment Agency as well as biographical interviews conducted with young rehabilitants. We compare the population of young rehabilitants with psychological disorders to those with other disabilities in terms of vocational rehabilitation and initial labor market entry in order to get a representative picture about their school to work transitions. Since rehabilitants with psychological disabilities tend to be older than the remaining population, analyses are stratified by age groups. In addition, qualitative in-depth interviews provide an additional and deeper understanding of specific employment barriers youth with psychological disorders have to overcome. Furthermore, the individual perspective gives insight on how the crucial transition from school to work is perceived by the population under study. Results The pathway into vocational rehabilitation of youth with psychological disorders is often characterized by obstacles in their transition from school to work. During rehabilitation, it appears essential to provide psychological stabilization along with vocational training. Although their average level of education is higher than those of other rehabilitants, labor market transition after (often company-external) vocational training challenges many young people with psychological disabilities, leaving many of them with comparatively poor labor market prospects. Conclusions Young persons with psychological disabilities, who come from regular schools or dropped out from regular school or university, seem to find their way to vocational rehabilitation more indirectly. Furthermore, vocational rehabilitation itself is often prolonged for those with psychological disabilities possibly due to a corresponding stabilization process. However, vocational rehabilitation can be a core element within the stabilization process of a psychological disease.}, language = {en} } @article{UngerTischTophoven2018, author = {Unger, Stefanie and Tisch, Anita and Tophoven, Silke}, title = {Age and gender differences in the impact of labour-market transitions on subjective health in Germany}, series = {Scandinavian journal of public health}, volume = {46}, journal = {Scandinavian journal of public health}, number = {19}, publisher = {Sage}, doi = {10.1177/1403494817738430}, pages = {49 -- 64}, year = {2018}, language = {en} } @techreport{TophovenWurdackRauchetal.2016, author = {Tophoven, Silke and Wurdack, Anja and Rauch, Angela and Munkert, Casandra and Bauer, Ulrike}, title = {lidA - leben in der Arbeit: German cohort study on work, age and health Documentation for waves 1 and 2}, volume = {FDZ Datenreport}, number = {01/2016 ENG}, year = {2016}, abstract = {The study "lidA - leben in der Arbeit. German cohort study on work, age and health" was a two-wave panel study funded by the Federal Ministry of Education and Research and examines the relationship between work, health and work participation among aging employees from an interdisciplinary perspective (www.lida-studie.de). The lidA study was carried out by an interdisciplinary consortium consisting of the Institute for Safety Technology at Bergische University Wuppertal, the Institute for Employment Research (IAB), Nuremberg, the Institute of Social Medicine and Health Economics at Otto-von-Guericke-University Magdeburg, the Institute of the History, Philosophy and Ethics of Medicine at Ulm University, infas Institute for Applied Social Sciences, Bonn and the Federal Institute for Occupational Safety and Health (BAuA), Berlin, as an associated partner. lidA contains a representative sample of persons belonging to the 1959 and 1965 birth cohorts and employed on the reference date for sampling, 31 December 2009. They were interviewed personally (CAPI) in 2011 (wave 1; N=6,585) and 2014 (wave 2; N=4,244). The data contain information about work and current employment relationship characteristics, work demands, workloads, subjective health indicators, socioeconomic status, household context and allow both cross-sectional and longitudinal analysis. This dataset is now available as a Scientific Use File for the scientific community via the Research Data Centre of the Federal Employment Agency at the Institute for Employment Research. The report contains information on data collection, data editing, anonymisation and the description of the variables of the two waves.}, language = {en} } @article{RoseSchielSchroederetal.2017, author = {Rose, Uwe and Schiel, Stefan and Schr{\"o}der, Helmut and Kleudgen, Martin and Tophoven, Silke and Rauch, Angela and Freude, Gabriele and M{\"u}ller, Grit}, title = {The study of mental health at work. design and sampling}, series = {Scandinavian journal of public health}, volume = {45}, journal = {Scandinavian journal of public health}, number = {6}, publisher = {Sage}, pages = {584 -- 594}, year = {2017}, language = {en} }