@article{AdamatzkySchnaussHuber2019, author = {Adamatzky, Andrew and Schnauß, J{\"o}rg and Huber, Florian}, title = {Actin droplet machine}, series = {Royal Society Open Science}, volume = {6}, journal = {Royal Society Open Science}, number = {12}, publisher = {Royal Soc. Publ.}, issn = {2054-5703}, doi = {10.1098/rsos.191135}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:due62-opus-34675}, year = {2019}, abstract = {The actin droplet machine is a computer model of a three-dimensional network of actin bundles developed in a droplet of a physiological solution, which implements mappings of sets of binary strings. The actin bundle network is conductive to travelling excitations, i.e. impulses. The machine is interfaced with an arbitrary selected set of k electrodes through which stimuli, binary strings of length k represented by impulses generated on the electrodes, are applied and responses are recorded. The responses are recorded in a form of impulses and then converted to binary strings. The machine's state is a binary string of length k: if there is an impulse recorded on the ith electrode, there is a '1' in the ith position of the string, and '0' otherwise. We present a design of the machine and analyse its state transition graphs. We envisage that actin droplet machines could form an elementary processor of future massive parallel computers made from biopolymers.}, language = {en} } @article{AdamatzkyHuberSchnauss2019, author = {Adamatzky, Andrew and Huber, Florian and Schnauß, J{\"o}rg}, title = {Computing on actin bundles network}, series = {Scientific Reports}, volume = {9}, journal = {Scientific Reports}, number = {1}, publisher = {Springer Nature}, issn = {2045-2322}, doi = {10.1038/s41598-019-51354-y}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:due62-opus-34665}, year = {2019}, abstract = {Actin filaments are conductive to ionic currents, mechanical and voltage solitons. These travelling localisations can be utilised to generate computing circuits from actin networks. The propagation of localisations on a single actin filament is experimentally unfeasible to control. Therefore, we consider excitation waves propagating on bundles of actin filaments. In computational experiments with a two-dimensional slice of an actin bundle network we show that by using an arbitrary arrangement of electrodes, it is possible to implement two-inputs-one-output circuits.}, language = {en} } @article{MiguelesRowlandsHuberetal.2019, author = {Migueles, Jairo H. and Rowlands, Alex V. and Huber, Florian and Sabia, S{\´e}verine and van Hees, Vincent T.}, title = {GGIR: A Research Community-Driven Open Source R Package for Generating Physical Activity and Sleep Outcomes From Multi-Day Raw Accelerometer Data}, series = {Journal for the Measurement of Physical Behaviour}, volume = {2}, journal = {Journal for the Measurement of Physical Behaviour}, number = {3}, publisher = {Human Kinetics}, issn = {2575-6605}, doi = {10.1123/jmpb.2018-0063}, pages = {188 -- 196}, year = {2019}, language = {en} } @article{BeniddirKangGentaJouveetal.2021, author = {Beniddir, Mehdi A. and Kang, Kyo Bin and Genta-Jouve, Gr{\´e}gory and Huber, Florian and Rogers, Simon and van der Hooft, Justin J. J.}, title = {Advances in decomposing complex metabolite mixtures using substructure- and network-based computational metabolomics approaches}, series = {Natural Product Reports}, volume = {38}, journal = {Natural Product Reports}, number = {11}, publisher = {The Royal Society of Chemistry}, issn = {1460-4752}, doi = {10.1039/D1NP00023C}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:due62-opus-34772}, pages = {1967 -- 1993}, year = {2021}, language = {en} } @article{HuberStrehleSchnaussetal.2015, author = {Huber, Florian and Strehle, Dan and Schnauß, J{\"o}rg and K{\"a}s, Josef}, title = {Formation of regularly spaced networks as a general feature of actin bundle condensation by entropic forces}, series = {New Journal of Physics}, volume = {17}, journal = {New Journal of Physics}, number = {4}, publisher = {IOP Publishing}, issn = {1367-2630}, doi = {10.1088/1367-2630/17/4/043029}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:due62-opus-34833}, year = {2015}, language = {en} } @article{HuberVerhoevenMeijeretal.2020, author = {Huber, Florian and Verhoeven, Stefan and Meijer, Christiaan and Spreeuw, Hanno and Castilla, Efra{\´i}n and Geng, Cunliang and van der Hooft, Justin J. J. and Rogers, Simon and Belloum, Adam and Diblen, Faruk and Spaaks, Jurriaan H.}, title = {matchms - processing and similarity evaluation of mass spectrometry data}, series = {Journal of Open Source Software}, volume = {5}, journal = {Journal of Open Source Software}, number = {52}, publisher = {Cold Spring Harbor Laboratory}, issn = {2475-9066}, doi = {10.21105/joss.02411}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:due62-opus-34856}, pages = {2411}, year = {2020}, language = {en} } @article{HuberKaesStuhrmann2008, author = {Huber, Florian and K{\"a}s, Josef and Stuhrmann, Bj{\"o}rn}, title = {Growing actin networks form lamellipodium and lamellum by self-assembly}, series = {Biophysical Journal}, volume = {95}, journal = {Biophysical Journal}, number = {12}, publisher = {Biophysical Society}, issn = {1542-0086}, doi = {10.1529/biophysj.108.134817}, pages = {5508 -- 5523}, year = {2008}, abstract = {Many different cell types are able to migrate by formation of a thin actin-based cytoskeletal extension. Recently, it became evident that this extension consists of two distinct substructures, designated lamellipodium and lamellum, which differ significantly in their kinetic and kinematic properties as well as their biochemical composition. We developed a stochastic two-dimensional computer simulation that includes chemical reaction kinetics, G-actin diffusion, and filament transport to investigate the formation of growing actin networks in migrating cells. Model parameters were chosen based on experimental data or theoretical considerations. In this work, we demonstrate the system's ability to form two distinct networks by self-organization. We found a characteristic transition in mean filament length as well as a distinct maximum in depolymerization flux, both within the first 1-2 microm. The separation into two distinct substructures was found to be extremely robust with respect to initial conditions and variation of model parameters. We quantitatively investigated the complex interplay between ADF/cofilin and tropomyosin and propose a plausible mechanism that leads to spatial separation of, respectively, ADF/cofilin- or tropomyosin-dominated compartments. Tropomyosin was found to play an important role in stabilizing the lamellar actin network. Furthermore, the influence of filament severing and annealing on the network properties is explored, and simulation data are compared to existing experimental data.}, language = {en} } @article{HuberKaes2011, author = {Huber, Florian and K{\"a}s, Josef}, title = {Self-regulative organization of the cytoskeleton}, series = {Cytoskeleton}, volume = {68}, journal = {Cytoskeleton}, number = {5}, publisher = {Wiley}, issn = {1949-3592}, doi = {10.1002/cm.20509}, pages = {259 -- 265}, year = {2011}, abstract = {Despite its impressive complexity the cytoskeleton succeeds to persistently organize itself and thus the cells' interior. In contrast to classical man-made machines, much of the cellular organization originates from inherent self-assembly and self-organization allowing a high degree of autonomy for various functional units. Recent experimental and theoretical studies revealed numerous examples of cytoskeleton components that arrange and organize in a self-regulative way. In the present review we want to shortly summarize some of the principle mechanisms that are able to inherently trigger and regulate the cytoskeleton organization. Although taken individually most of these regulative principles are rather simple with intuitively predictable consequences, combinations of two or more of these mechanisms can quickly give rise to very complex, unexpected behavior and might even be able to explain the formation of different functional units out of a common pool of available building blocks.}, language = {en} } @article{StuhrmannHuberKaes2011, author = {Stuhrmann, Bj{\"o}rn and Huber, Florian and K{\"a}s, Josef}, title = {Robust organizational principles of protrusive biopolymer networks in migrating living cells}, series = {Plos One}, volume = {6}, journal = {Plos One}, number = {1}, publisher = {Public Library of Science (PLoS)}, issn = {1932-6203}, doi = {10.1371/journal.pone.0014471}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:due62-opus-34901}, year = {2011}, abstract = {Cell migration is associated with the dynamic protrusion of a thin actin-based cytoskeletal extension at the cell front, which has been shown to consist of two different substructures, the leading lamellipodium and the subsequent lamellum. While the formation of the lamellipodium is increasingly well understood, organizational principles underlying the emergence of the lamellum are just beginning to be unraveled. We report here on a 1D mathematical model which describes the reaction-diffusion processes of a polarized actin network in steady state, and reproduces essential characteristics of the lamellipodium-lamellum system. We observe a steep gradient in filament lengths at the protruding edge, a local depolymerization maximum a few microns behind the edge, as well as a differential dominance of the network destabilizer ADF/cofilin and the stabilizer tropomyosin. We identify simple and robust organizational principles giving rise to the derived network characteristics, uncoupled from the specifics of any molecular implementation, and thus plausibly valid across cell types. An analysis of network length dependence on physico-chemical system parameters implies that to limit array treadmilling to cellular dimensions, network growth has to be truncated by mechanisms other than aging-induced depolymerization, e.g., by myosin-associated network dissociation at the transition to the cell body. Our work contributes to the analytical understanding of the cytoskeletal extension's bisection into lamellipodium and lamellum and sheds light on how cells organize their molecular machinery to achieve motility.}, language = {en} } @article{PreciadoLopezHuberGrigorievetal.2014, author = {Preciado L{\´o}pez, Magdalena and Huber, Florian and Grigoriev, Ilya and Steinmetz, Michel O. and Akhmanova, Anna and Koenderink, Gijsje H. and Dogterom, Marileen}, title = {Actin-microtubule coordination at growing microtubule ends}, series = {Nature Communications}, volume = {5}, journal = {Nature Communications}, publisher = {Springer Nature}, issn = {2041-1723}, doi = {10.1038/ncomms5778}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:due62-opus-34878}, pages = {4778}, year = {2014}, abstract = {To power dynamic processes in cells, the actin and microtubule cytoskeletons organize into complex structures. Although it is known that cytoskeletal coordination is vital for cell function, the mechanisms by which cross-linking proteins coordinate actin and microtubule activities remain poorly understood. In particular, it is unknown how the distinct mechanical properties of different actin architectures modulate the outcome of actin-microtubule interactions. To address this question, we engineered the protein TipAct, which links growing microtubule ends via end-binding proteins to actin filaments. We show that growing microtubules can be captured and guided by stiff actin bundles, leading to global actin-microtubule alignment. Conversely, growing microtubule ends can transport, stretch and bundle individual actin filaments, thereby globally defining actin filament organization. Our results provide a physical basis to understand actin-microtubule cross-talk, and reveal that a simple cross-linker can enable a mechanical feedback between actin and microtubule organization that is relevant to diverse biological contexts.}, language = {en} } @article{JohanningBraunTimoneyetal.2009, author = {Johanning, M. and Braun, Alexander and Timoney, N. and Elman, V. and Neuhauser, W. and Wunderlich, Chr}, title = {Individual addressing of trapped ions and coupling of motional and spin states using RF radiation}, series = {Physical review letters}, volume = {102}, journal = {Physical review letters}, number = {7}, publisher = {American Physical Society}, issn = {1079-7114}, doi = {10.1103/PhysRevLett.102.073004}, year = {2009}, abstract = {Individual electrodynamically trapped and laser cooled ions are addressed in frequency space using radio-frequency radiation in the presence of a static magnetic field gradient. In addition, an interaction between motional and spin states induced by an rf field is demonstrated employing rf optical double resonance spectroscopy. These are two essential experimental steps towards realizing a novel concept for implementing quantum simulations and quantum computing with trapped ions.}, language = {en} } @article{JohanningBraunEiteneueretal.2011, author = {Johanning, M. and Braun, Alexander and Eiteneuer, D. and Paape, C. and Balzer, C. and Neuhauser, W. and Wunderlich, C.}, title = {Resonance-enhanced isotope-selective photoionization of YbI for ion trap loading}, series = {Applied Physics B}, volume = {103}, journal = {Applied Physics B}, number = {2}, publisher = {Springer Nature}, issn = {1432-0649}, doi = {10.1007/s00340-011-4502-7}, pages = {327 -- 338}, year = {2011}, language = {en} } @article{VossMusallLichtmess2011, author = {Voss, Karsten and Musall, Eike and Lichtmeß, Markus}, title = {From Low Energy to Net Zero-Energy Buildings: Status and Perspectives}, series = {Journal of Green Building}, volume = {6}, journal = {Journal of Green Building}, number = {1}, publisher = {College Publishing}, doi = {10.3992/jgb.6.1.46}, pages = {46 -- 57}, year = {2011}, abstract = {"Net Zero-Energy Building" has become a popular catchphrase to describe the synergy between energy-efficient building and renewable energy utilisation to achieve a balanced energy budget over an annual cycle. Taking into account the energy exchange with a grid overcomes the limitations of energy-autonomous buildings with the need for seasonal energy storage on-site. Although the expression, "Net Zero-Energy Building," appears in many energy policy documents, a harmonised definition or a standardised balancing method is still lacking. This paper reports on the background and the various effects influencing the energy balance approach. After discussing the national energy code framework in Germany, a harmonised terminology and balancing procedure is proposed. The procedure takes not only the energy balance but also energy efficiency and load matching into account.}, language = {en} } @article{VossMusall2011, author = {Voss, Karsten and Musall, Eike}, title = {Null- und Plusenergiegeb{\"a}ude: Allgemeine Bilanzierungsverfahren und Schnittstellen zur normativen Praxis in Deutschland}, series = {EnEVaktuell}, journal = {EnEVaktuell}, number = {IV}, publisher = {DIN Deutsches Institut f{\"u}r Normung e.V.}, pages = {3 -- 5}, year = {2011}, abstract = {Die Begriffe „Nullenergiehaus" oder „Plusenergiehaus" sind in den letzten Jahren national und international zum Inbegriff f{\"u}r die konsequente Zusammenf{\"u}hrung von Maßnahmen zur drastischen Energieeinsparung und optimierter, dezentraler Nutzung erneuerbarer Energien geworden. Dabei geht es nicht um energieautarke Geb{\"a}ude und die dabei große Herausforderung der saisonalen Energiespeicherung. Grundidee ist, dass die von einem Geb{\"a}ude in ein Netz eingespeiste Energiemenge in der Jahresbilanz mindestens dem Energiebezug entspricht. Sowohl im Kontext der Fortf{\"u}hrung der europ{\"a}ischen Geb{\"a}uderichtline als auch im aktuellen Energiekonzept und Energieforschungsprogramm der Bundesregierung wird das Thema besetzt.}, language = {de} } @article{MusallVoss2014, author = {Musall, Eike and Voss, Karsten}, title = {Renewable Energy Ratio in Net Zero Energy Buildings}, series = {REHVA Journal}, volume = {51}, journal = {REHVA Journal}, number = {3}, publisher = {REHVA}, pages = {14 -- 18}, year = {2014}, language = {en} } @article{deBanffyHallHill2017, author = {de B{\´a}nffy-Hall, Alicia and Hill, Burkhard}, title = {Community Music: Eine Einf{\"u}hrung}, series = {KULTURELLE BILDUNG ONLINE}, journal = {KULTURELLE BILDUNG ONLINE}, publisher = {Bundesakademie f{\"u}r Kulturelle Bildung}, doi = {10.25529/92552.79}, year = {2017}, language = {de} } @article{deBanffyHallHill2017, author = {de B{\´a}nffy-Hall, Alicia and Hill, Burkhard}, title = {Community Music: Eine Einf{\"u}hrung}, series = {kubi-online}, journal = {kubi-online}, year = {2017}, language = {de} } @article{Hoerner2015, author = {H{\"o}rner, Fernand}, title = {La flexibilit{\´e} historique de l'aura : de Walter Benjamin {\`a} Radiohead}, series = {Communication \& Langages}, volume = {2}, journal = {Communication \& Langages}, number = {184}, publisher = {cairn-int.info}, organization = {cairn-int.info}, doi = {10.4074/S0336150015012041}, pages = {61 -- 77}, year = {2015}, language = {fr} } @article{HiesingerTophoven2019, author = {Hiesinger, Karolin and Tophoven, Silke}, title = {Job requirement level, work demands, and health: a prospective study among older workers}, series = {International Archives of Occupational and Environmental Health}, volume = {92}, journal = {International Archives of Occupational and Environmental Health}, publisher = {Springer Nature}, doi = {10.1007/s00420-019-01451-2}, pages = {1139 -- 1149}, year = {2019}, language = {en} } @article{HiesingerTophovenMarch2018, author = {Hiesinger, Karolin and Tophoven, Silke and March, Stefanie}, title = {Geschlechtsspezifische Verzerrungen bei der Erfassung von Depressivit{\"a}t}, series = {Pr{\"a}vention und Gesundheitsf{\"o}rderung}, volume = {13}, journal = {Pr{\"a}vention und Gesundheitsf{\"o}rderung}, number = {3}, publisher = {Springer Nature}, doi = {10.1007/s11553-017-0634-x}, pages = {211 -- 217}, year = {2018}, language = {de} } @article{Tophoven2017, author = {Tophoven, Silke}, title = {Buchbesprechung: Siegrist, J./Wahrendorf, M. (Hrsg.) (2016): Work Stress and Health in a Globalized Economy. The Model of Effort-Reward Imbalance. Cham: Springer International Publishing}, series = {WSI-Mitteilungen}, volume = {70}, journal = {WSI-Mitteilungen}, number = {3}, publisher = {Nomos}, pages = {224}, year = {2017}, language = {de} } @article{TophovenTisch2016, author = {Tophoven, Silke and Tisch, Anita}, title = {Dimensionen prek{\"a}rer Besch{\"a}ftigung und Gesundheit im mittleren Lebensalter}, series = {WSI-Mitteilungen}, volume = {69}, journal = {WSI-Mitteilungen}, number = {2}, publisher = {Nomos}, doi = {10.5771/0342-300X-2016-2-105}, pages = {105 -- 112}, year = {2016}, language = {de} } @article{KellyIrvingTophovenBlane2015, author = {Kelly-Irving, Michelle and Tophoven, Silke and Blane, David}, title = {Editorial: Life course research: new opportunities for establishing social and biological plausibility}, series = {International journal of public health}, volume = {60}, journal = {International journal of public health}, number = {6}, publisher = {Springer Nature}, doi = {10.1007/s00038-015-0688-5}, pages = {629 -- 630}, year = {2015}, language = {en} } @article{RauchTophovenEggsetal.2015, author = {Rauch, Angela and Tophoven, Silke and Eggs, Johannes and Tisch, Anita}, title = {Arbeitsbezogene gesundheitsrelevante Faktoren im fortgeschrittenen Erwerbsalter: eine Studie mit neuen Analysem{\"o}glichkeiten}, series = {WSI-Mitteilungen}, volume = {68}, journal = {WSI-Mitteilungen}, number = {3}, publisher = {Nomos}, doi = {10.5771/0342-300X-2015-3-212}, pages = {212 -- 218}, year = {2015}, language = {de} } @article{WillersDeckert2015, author = {Willers, Christoph and Deckert, Carsten}, title = {eFood in Deutschland}, series = {Der Betriebswirt}, volume = {56}, journal = {Der Betriebswirt}, number = {11}, publisher = {Duncker \& Humblot}, doi = {10.3790/dbw.56.4.10}, pages = {10 -- 15}, year = {2015}, abstract = {Im Vergleich zu „Pionierbranchen" wie Mode oder Medien steht der Online-Handel mit Lebensmitteln erst am Anfang. Dabei kann dieser zu einem Wettbewerbsvorteil werden - wenn der Handel es richtig angeht. Auf der anderen Seite steht das Risiko einer strategischen Falle, d.h. es wird unter Umst{\"a}nden aufgrund der Widerst{\"a}nde beim Verbraucher nur ein Nischenmarkt bedient, der eine geringe Profitabilit{\"a}t aufweist. Im Spannungsfeld „Marktpotenzial auf Handelsseite" vs. „Zur{\"u}ckhaltung beim Verbraucher" r{\"u}cken dabei Fragen der Kommunikationspolitik im Online-Lebensmittelhandel in den Fokus. F{\"u}r eine erfolgreiche Umsetzung stellt eine eindeutige Typologie eine notwendige Basis dar, um die konkreten Bed{\"u}rfnisse potenzieller Konsumenten anzusprechen. Ein Engagement im eFood-Bereich ist daher als Investition in die zuk{\"u}nftige Entwicklung der M{\"a}rkte und ihrer Zielgruppen zu betrachten. Although online trading in the food sector is still in early stages, it may become a competitive edge - if retailers go about it the right way. On the other hand, due to consumer resistance, there is the risk of serving only a niche market, which cannot be maintained in terms of profitability. Therefore, a stronger focus on communication policies is needed. Engaging in the eFood sector finally has to be seen as an important investment into future markets and their target groups. Keywords: online lebensmittelhandel, lieferfenster, informationszeitalter, face to the customer}, language = {de} } @article{KampaFinkeStalderetal.2022, author = {Kampa, Miriam and Finke, Johannes and Stalder, Tobias and Bucher, Leandra and Klapperich, Holger and Mertl, Fabian and Zimmer, Christian and Geiger, Christian and Hassenzahl, Marc and Klucken, Tim}, title = {Facilitating relaxation and stress reduction in healthy participants through a virtual reality intervention: study protocol for a non-inferiority randomized controlled trial}, series = {Trials}, volume = {23}, journal = {Trials}, publisher = {BMC}, issn = {1745-6215}, doi = {10.1186/s13063-022-06307-8}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:due62-opus-40118}, year = {2022}, language = {en} } @article{HubervanderBurgvanderHooftetal.2021, author = {Huber, Florian and van der Burg, Sven and van der Hooft, Justin J. J. and Ridder, Lars}, title = {MS2DeepScore: a novel deep learning similarity measure to compare tandem mass spectra}, series = {Journal of Cheminformatics}, volume = {13}, journal = {Journal of Cheminformatics}, number = {1}, publisher = {Cold Spring Harbor Laboratory}, issn = {1758-2946}, doi = {10.1186/s13321-021-00558-4}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:due62-opus-34847}, pages = {84}, year = {2021}, abstract = {Mass spectrometry data is one of the key sources of information in many workflows in medicine and across the life sciences. Mass fragmentation spectra are generally considered to be characteristic signatures of the chemical compound they originate from, yet the chemical structure itself usually cannot be easily deduced from the spectrum. Often, spectral similarity measures are used as a proxy for structural similarity but this approach is strongly limited by a generally poor correlation between both metrics. Here, we propose MS2DeepScore: a novel Siamese neural network to predict the structural similarity between two chemical structures solely based on their MS/MS fragmentation spectra. Using a cleaned dataset of > 100,000 mass spectra of about 15,000 unique known compounds, we trained MS2DeepScore to predict structural similarity scores for spectrum pairs with high accuracy. In addition, sampling different model varieties through Monte-Carlo Dropout is used to further improve the predictions and assess the model's prediction uncertainty. On 3600 spectra of 500 unseen compounds, MS2DeepScore is able to identify highly-reliable structural matches and to predict Tanimoto scores for pairs of molecules based on their fragment spectra with a root mean squared error of about 0.15. Furthermore, the prediction uncertainty estimate can be used to select a subset of predictions with a root mean squared error of about 0.1. Furthermore, we demonstrate that MS2DeepScore outperforms classical spectral similarity measures in retrieving chemically related compound pairs from large mass spectral datasets, thereby illustrating its potential for spectral library matching. Finally, MS2DeepScore can also be used to create chemically meaningful mass spectral embeddings that could be used to cluster large numbers of spectra. Added to the recently introduced unsupervised Spec2Vec metric, we believe that machine learning-supported mass spectral similarity measures have great potential for a range of metabolomics data processing pipelines.}, language = {en} } @article{KernebeckHollePogschebaetal.2019, author = {Kernebeck, Sven and Holle, Daniela and Pogscheba, Patrick and Jordan, Felix and Mertl, Fabian and Huldtgren, Alina and Bader, Sebastian and Kirste, Thomas and Teipel, Stefan and Holle, Bernhard and Halek, Margareta}, title = {A Tablet App- and Sensor-Based Assistive Technology Intervention for Informal Caregivers to Manage the Challenging Behavior of People With Dementia (the insideDEM Study): Protocol for a Feasibility Study}, series = {JMIR research protocols}, volume = {8}, journal = {JMIR research protocols}, number = {2}, publisher = {JMIR}, doi = {10.2196/11630}, year = {2019}, language = {en} } @article{GalbanMaderwaldEggebrechtetal.2005, author = {Galban, Craig and Maderwald, Stefan and Eggebrecht, Holger and Grote, Wolfgang and de Greiff, A. and Uffmann, K. and Ladd, M. E.}, title = {Monitoring the Effects of Chronic Obstructive Pulmonary Disease on Muscle Elasticity by MR Elastography}, series = {Proc. Intl. Soc. Mag. Reson. Med.}, volume = {13}, journal = {Proc. Intl. Soc. Mag. Reson. Med.}, pages = {2015}, year = {2005}, abstract = {Men afflicted with chronic obstructive pulmonary disease (COPD) show signs of muscle dysfunction, such as increased muscle fatigue and acidosis during exercise. We hypothesize that muscle elasticity of the lower extremities differs between patients with COPD and age-related controls. The shear modulus of the soleus muscle was measured non-invasively using MR elastography (MRE) at 0\%, 5\%, 10\%, 15\%, and 20\% of the subject's maximum applied force. The results from this study showed statistical differences between the patients and controls, even though there were no statistical differences in the maximum applied force.}, language = {en} } @article{GalbanMaderwaldHerrmannetal.2005, author = {Galban, Craig and Maderwald, Stefan and Herrmann, Burkhard and Brauck, K. and Grote, Wolfgang and de Greiff, A. and Uffmann, K. and Ladd, M.}, title = {Measuring Skeletal Muscle Elasticity in Patients with Hypogonadism by MR Elastography}, series = {Proc. Intl. Soc. Mag. Reson. Med.}, volume = {13}, journal = {Proc. Intl. Soc. Mag. Reson. Med.}, pages = {2016}, year = {2005}, abstract = {Men afflicted with hypogonadism have reduced fat-free mass and in some cases a loss in muscle strength. We hypothesize that muscle elasticity of the lower extremities differs between patients with hypogonadism and healthy controls. The shear modulus of the soleus muscle was measured non-invasively using MR elastography (MRE) at 0\%, 5\%, 10\%, 15\%, and 20\% of the subject's maximum applied force. The results from this study showed statistical differences between the patients and controls, even though there were no statistical differences in applied force.}, language = {en} } @article{SieberichsGeerkensBraunetal.2024, author = {Sieberichs, Christian and Geerkens, Simon and Braun, Alexander and Waschulzik, Thomas}, title = {ECS: an interactive tool for data quality assurance}, series = {AI and Ethics}, journal = {AI and Ethics}, publisher = {Springer Nature}, issn = {2730-5961}, doi = {10.1007/s43681-023-00393-3}, year = {2024}, abstract = {With the increasing capabilities of machine learning systems and their potential use in safety-critical systems, ensuring high-quality data is becoming increasingly important. In this paper, we present a novel approach for the assurance of data quality. For this purpose, the mathematical basics are first discussed and the approach is presented using multiple examples. This results in the detection of data points with potentially harmful properties for the use in safety-critical systems.}, language = {en} } @article{ZimmermannNeumannCeliketal.2011, author = {Zimmermann, Peter and Neumann, Anna and {\c{C}}elik, Fatma and Kindler, Heinz}, title = {Sexuelle Gewalt gegen Kinder in Familien - Ein Forschungs{\"u}berblick}, series = {Sexuologie. Zeitschrift f{\"u}r Sexualmedizin, Sexualtherapie und Sexualwissenschaft}, volume = {18}, journal = {Sexuologie. Zeitschrift f{\"u}r Sexualmedizin, Sexualtherapie und Sexualwissenschaft}, number = {34}, publisher = {Deutsche Gesellschaft f{\"u}r Sexualmedizin, Sexualtherapie und Sexualwissenschaft}, issn = {0944-7105}, doi = {10.61387/S.2011.34.16}, pages = {119 -- 142}, year = {2011}, language = {de} }