@article{MullowneyDuncanElsayedetal.2023, author = {Mullowney, Michael W. and Duncan, Katherine R. and Elsayed, Somayah S. and Garg, Neha and van der Hooft, Justin J. J. and Martin, Nathaniel I. and Meijer, David and Terlouw, Barbara R. and Biermann, Friederike and Blin, Kai and Durairaj, Janani and Gorostiola Gonz{\´a}lez, Marina and Helfrich, Eric J. N. and Huber, Florian and Leopold-Messer, Stefan and Rajan, Kohulan and de Rond, Tristan and van Santen, Jeffrey A. and Sorokina, Maria and Balunas, Marcy J. and Beniddir, Mehdi A. and van Bergeijk, Doris A. and Carroll, Laura M. and Clark, Chase M. and Clevert, Djork-Arn{\´e} and Dejong, Chris A. and Du, Chao and Ferrinho, Scarlet and Grisoni, Francesca and Hofstetter, Albert and Jespers, Willem and Kalinina, Olga V. and Kautsar, Satria A. and Kim, Hyunwoo and Leao, Tiago F. and Masschelein, Joleen and Rees, Evan R. and Reher, Raphael and Reker, Daniel and Schwaller, Philippe and Segler, Marwin and Skinnider, Michael A. and Walker, Allison S. and Willighagen, Egon L. and Zdrazil, Barbara and Ziemert, Nadine and Goss, Rebecca J. M. and Guyomard, Pierre and Volkamer, Andrea and Gerwick, William H. and Kim, Hyun Uk and M{\"u}ller, Rolf and van Wezel, Gilles P. and van Westen, Gerard J. P. and Hirsch, Anna K. H. and Linington, Roger G. and Robinson, Serina L. and Medema, Marnix H.}, title = {Artificial intelligence for natural product drug discovery}, series = {Nature Reviews Drug Discovery}, volume = {22}, journal = {Nature Reviews Drug Discovery}, number = {11}, publisher = {Springer Nature}, issn = {1474-1776}, doi = {10.1038/s41573-023-00774-7}, pages = {895 -- 916}, year = {2023}, subject = {Maschinelles Lernen}, language = {en} } @article{SchornVerhoevenRidderetal.2021, author = {Schorn, Michelle A. and Verhoeven, Stefan and Ridder, Lars and Huber, Florian and Acharya, Deepa D. and Aksenov, Alexander A. and Aleti, Gajender and Moghaddam, Jamshid Amiri and Aron, Allegra T. and Aziz, Saefuddin and Bauermeister, Anelize and Bauman, Katherine D. and Baunach, Martin and Beemelmanns, Christine and Beman, J. Michael and Berlanga-Clavero, Mar{\´i}a Victoria and Blacutt, Alex A. and Bode, Helge B. and Boullie, Anne and Brejnrod, Asker and Bugni, Tim S. and Calteau, Alexandra and Cao, Liu and Carri{\´o}n, V{\´i}ctor J. and Castelo-Branco, Raquel and Chanana, Shaurya and Chase, Alexander B. and Chevrette, Marc G. and Costa-Lotufo, Leticia V. and Crawford, Jason M. and Currie, Cameron R. and Cuypers, Bart and Dang, Tam and de Rond, Tristan and Demko, Alyssa M. and Dittmann, Elke and Du, Chao and Drozd, Christopher and Dujardin, Jean-Claude and Dutton, Rachel J. and Edlund, Anna and Fewer, David P. and Garg, Neha and Gauglitz, Julia M. and Gentry, Emily C. and Gerwick, Lena and Glukhov, Evgenia and Gross, Harald and Gugger, Muriel and Guill{\´e}n Matus, Dulce G. and Helfrich, Eric J. N. and Hempel, Benjamin-Florian and Hur, Jae-Seoun and Iorio, Marianna and Jensen, Paul R. and Kang, Kyo Bin and Kaysser, Leonard and Kelleher, Neil L. and Kim, Chung Sub and Kim, Ki Hyun and Koester, Irina and K{\"o}nig, Gabriele M. and Leao, Tiago and Lee, Seoung Rak and Lee, Yi-Yuan and Li, Xuanji and Little, Jessica C. and Maloney, Katherine N. and M{\"a}nnle, Daniel and Martin H, Christian and McAvoy, Andrew C. and Metcalf, Willam W. and Mohimani, Hosein and Molina-Santiago, Carlos and Moore, Bradley S. and Mullowney, Michael W. and Muskat, Mitchell and Nothias, Louis-F{\´e}lix and O'Neill, Ellis C. and Parkinson, Elizabeth I. and Petras, Daniel and Piel, J{\"o}rn and Pierce, Emily C. and Pires, Karine and Reher, Raphael and Romero, Diego and Roper, M. Caroline and Rust, Michael and Saad, Hamada and Saenz, Carmen and Sanchez, Laura M. and S{\o}rensen, S{\o}ren Johannes and Sosio, Margherita and S{\"u}ssmuth, Roderich D. and Sweeney, Douglas and Tahlan, Kapil and Thomson, Regan J. and Tobias, Nicholas J. and Trindade-Silva, Amaro E. and van Wezel, Gilles P. and Wang, Mingxun and Weldon, Kelly C. and Zhang, Fan and Ziemert, Nadine and Duncan, Katherine R. and Cr{\"u}semann, Max and Rogers, Simon and Dorrestein, Pieter C. and Medema, Marnix H. and van der Hooft, Justin J. J.}, title = {A community resource for paired genomic and metabolomic data mining}, series = {Nature Chemical Biology}, volume = {17}, journal = {Nature Chemical Biology}, number = {4}, publisher = {Nature}, issn = {1552-4469}, doi = {10.1038/s41589-020-00724-z}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:due62-opus-34708}, pages = {363 -- 368}, year = {2021}, language = {en} } @article{GeneralPoehlerSihleretal.2014, author = {General, S. and P{\"o}hler, D. and Sihler, H. and Bobrowski, N. and Frieß, U. and Zielcke, J. and Horbanski, M. and Shepson, P. B. and Stirm, B. H. and Simpson, W. R. and Weber, Konradin and Fischer, C. and Platt, U.}, title = {The Heidelberg Airborne Imaging DOAS Instrument (HAIDI) - a novel imaging DOAS device for 2-D and 3-D imaging of trace gases and aerosols}, series = {Atmospheric Measurement Techniques}, volume = {7}, journal = {Atmospheric Measurement Techniques}, number = {10}, publisher = {Copernicus}, issn = {1867-8548}, doi = {10.5194/amt-7-3459-2014}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:due62-opus-50179}, pages = {3459 -- 3485}, year = {2014}, abstract = {Abstract. Many relevant processes in tropospheric chemistry take place on rather small scales (e.g., tens to hundreds of meters) but often influence areas of several square kilometer. Thus, measurements of the involved trace gases with high spatial resolution are of great scientific interest. In order to identify individual sources and sinks and ultimately to improve chemical transport models, we developed a new airborne instrument, which is based on the well established Differential Optical Absorption Spectroscopy (DOAS) method. The Heidelberg Airborne Imaging DOAS Instrument (HAIDI) is a passive imaging DOAS spectrometer, which is capable of recording horizontal and vertical trace gas distributions with a resolution of better than 100 m. Observable species include NO2, HCHO, C2H2O2, H2O, O3, O4, SO2, IO, OClO and BrO. Here we give a technical description of the instrument including its custom-built spectrographs and CCD detectors. Also first results from measurements with the new instrument are presented. These comprise spatial resolved SO2 and BrO in volcanic plumes, mapped at Mt. Etna (Sicily, Italy), NO2 emissions in the metropolitan area of Indianapolis (Indiana, USA) as well as BrO and NO2 distributions measured during arctic springtime in context of the BRomine, Ozone, and Mercury EXperiment (BROMEX) campaign, which was performed 2012 in Barrow (Alaska, USA).}, language = {en} } @article{VansteenkisteDeBaerdemaekerChouetal.2008, author = {Vansteenkiste, A. and De Baerdemaeker, J. and Chou, Kang Wei and Stoll, H. and Curcic, Michael and Tyliszczak, T. and Woltersdorf, G. and Back, Christian H. and Sch{\"u}tz, G. and Van Waeyenberge, B.}, title = {Influence of domain wall pinning on the dynamic behavior of magnetic vortex structures: Time-resolved scanning x-ray transmission microscopy in NiFe thin film structures}, series = {Physical Review B}, volume = {77}, journal = {Physical Review B}, number = {14}, publisher = {American Physical Society}, issn = {1098-0121}, doi = {10.1103/PhysRevB.77.144420}, year = {2008}, language = {en} } @article{VansteenkisteChouWeigandetal.2009, author = {Vansteenkiste, A. and Chou, Kang Wei and Weigand, M. and Curcic, Michael and Sackmann, V. and Stoll, H. and Tyliszczak, T. and Woltersdorf, G. and Back, Christian H. and Sch{\"u}tz, G. and Van Waeyenberge, B.}, title = {X-ray imaging of the dynamic magnetic vortex core deformation}, series = {Nature Physics}, volume = {5}, journal = {Nature Physics}, number = {5}, publisher = {Nature Publishing Group}, issn = {1745-2473}, doi = {10.1038/nphys1231}, pages = {332 -- 334}, year = {2009}, language = {en} } @article{EmanuelssonHallquistKristensenetal.2013, author = {Emanuelsson, E. U. and Hallquist, M. and Kristensen, K. and Glasius, M. and Bohn, Birger and Fuchs, H. and Kammer, B. and Kiendler-Scharr, A. and Nehr, Sascha and Rubach, F. and Tillmann, R. and Wahner, A. and Wu, H.-C. and Mentel, Th. F.}, title = {Formation of anthropogenic secondary organic aerosol (SOA) and its influence on biogenic SOA properties}, series = {Atmospheric Chemistry and Physics}, volume = {13}, journal = {Atmospheric Chemistry and Physics}, number = {5}, publisher = {Copernicus}, issn = {1680-7324}, doi = {10.5194/acp-13-2837-2013}, pages = {2837 -- 2855}, year = {2013}, abstract = {Abstract. Secondary organic aerosol (SOA) formation from mixed anthropogenic and biogenic precursors has been studied exposing reaction mixtures to natural sunlight in the SAPHIR chamber in J{\"u}lich, Germany. In this study aromatic compounds served as examples of anthropogenic volatile organic compound (VOC) and a mixture of α-pinene and limonene as an example for biogenic VOC. Several experiments with exclusively aromatic precursors were performed to establish a relationship between yield and organic aerosol mass loading for the atmospheric relevant range of aerosol loads of 0.01 to 10 μg m-3. The yields (0.5 to 9\%) were comparable to previous data and further used for the detailed evaluation of the mixed biogenic and anthropogenic experiments. For the mixed experiments a number of different oxidation schemes were addressed. The reactivity, the sequence of addition, and the amount of the precursors influenced the SOA properties. Monoterpene oxidation products, including carboxylic acids and dimer esters were identified in the aged aerosol at levels comparable to ambient air. OH radicals were measured by Laser Induced Fluorescence, which allowed for establishing relations of aerosol properties and composition to the experimental OH dose. Furthermore, the OH measurements in combination with the derived yields for aromatic SOA enabled application of a simplified model to calculate the chemical turnover of the aromatic precursor and corresponding anthropogenic contribution to the mixed aerosol. The estimated anthropogenic contributions were ranging from small (\&amp;approx;8\%) up to significant fraction (50\%) providing a suitable range to study the effect of aerosol composition on the aerosol volatility (volume fraction remaining (VFR) at 343 K: 0.86-0.94). The aromatic aerosol had higher oxygen to carbon ratio O/C and was less volatile than the biogenic fraction. However, in order to produce significant amount of aromatic SOA the reaction mixtures needed a higher OH dose that also increased O/C and provided a less volatile aerosol. The SOA yields, O/C, and f44 (the mass fraction of CO2+ ions in the mass spectra which can be considered as a measure of carboxylic groups) in the mixed photo-chemical experiments could be described as linear combinations of the corresponding properties of the pure systems. For VFR there was in addition an enhancement effect, making the mixed aerosol significantly less volatile than what could be predicted from the pure systems. A strong positive correlation was found between changes in volatility and O/C with the exception during dark hours where the SOA volatility decreased while O/C did not change significantly. Thus, this change in volatility under dark conditions as well as the anthropogenic enhancement is due to chemical or morphological changes not affecting O/C.}, language = {en} } @article{LuRohrerHollandetal.2012, author = {Lu, K. D. and Rohrer, F. and Holland, F. and Fuchs, H. and Bohn, Birger and Brauers, Theo and Chang, C. C. and H{\"a}seler, R. and Hu, M. and Kita, K. and Kondo, Y. and Li, X. and Lou, S. R. and Nehr, Sascha and Shao, M. and Zeng, L. M. and Wahner, A. and Zhang, Y. H. and Hofzumahaus, A.}, title = {Observation and modelling of OH and HO2 concentrations in the Pearl River Delta 2006: a missing OH source in a VOC rich atmosphere}, series = {Atmospheric Chemistry and Physics}, volume = {12}, journal = {Atmospheric Chemistry and Physics}, number = {3}, publisher = {Copernicus}, issn = {1680-7324}, doi = {10.5194/acp-12-1541-2012}, pages = {1541 -- 1569}, year = {2012}, abstract = {Abstract. Ambient OH and HO2 concentrations were measured by laser induced fluorescence (LIF) during the PRIDE-PRD2006 (Program of Regional Integrated Experiments of Air Quality over the Pearl River Delta, 2006) campaign at a rural site downwind of the megacity of Guangzhou in Southern China. The observed OH concentrations reached daily peak values of (15-26) × 106 cm-3 which are among the highest values so far reported for urban and suburban areas. The observed OH shows a consistent high correlation with j(O1D) over a broad range of NOx conditions. The correlation cannot be reproduced by model simulations, indicating that OH stabilizing processes are missing in current models. The observed OH exhibited a weak dependence on NOx in contrast to model predictions. While modelled and measured OH agree well at NO mixing ratios above 1 ppb, a continuously increasing underprediction of the observed OH is found towards lower NO concentrations, reaching a factor of 8 at 0.02 ppb NO. A dependence of the modelled-to-measured OH ratio on isoprene cannot be concluded from the PRD data. However, the magnitude of the ratio fits into the isoprene dependent trend that was reported from other campaigns in forested regions. Hofzumahaus et al. (2009) proposed an unknown OH recycling process without NO, in order to explain the high OH levels at PRD in the presence of high VOC reactivity and low NO. Taking a recently discovered interference in the LIF measurement of HO2 into account, the need for an additional HO2 → OH recycling process persists, but the required source strength may be up to 20\% larger than previously determined. Recently postulated isoprene mechanisms by Lelieveld et al. (2008) and Peeters and M{\"u}ller (2010) lead to significant enhancements of OH expected for PRD, but an underprediction of the observed OH by a factor of two remains at low NO (0.1-0.2 ppb). If the photolysis of hydroperoxy aldehydes from isoprene is as efficient as proposed by Peeters and M{\"u}ller (2010), the corresponding OH formation at PRD would be more important than the primary OH production from ozone and HONO. While the new isoprene mechanisms need to be confirmed by laboratory experiments, there is probably need for other, so far unidentified chemical processes to explain entirely the high OH levels observed in Southern China.}, language = {en} } @misc{GottschaldAdamMarx2014, author = {Gottschald, Jonas and Adam, Mario and Marx, H.}, title = {Heiztechnik - Langzeitmessergebnisse eines vakuumisolierten Warmwasserspeichers}, series = {HLH Heizung - L{\"u}ftung - Haustechnik}, volume = {64}, journal = {HLH Heizung - L{\"u}ftung - Haustechnik}, number = {4}, publisher = {VDI-Verlag}, issn = {0017-9906}, pages = {20 -- 25}, year = {2014}, language = {de} } @article{MiguelesRowlandsHuberetal.2019, author = {Migueles, Jairo H. and Rowlands, Alex V. and Huber, Florian and Sabia, S{\´e}verine and van Hees, Vincent T.}, title = {GGIR: A Research Community-Driven Open Source R Package for Generating Physical Activity and Sleep Outcomes From Multi-Day Raw Accelerometer Data}, series = {Journal for the Measurement of Physical Behaviour}, volume = {2}, journal = {Journal for the Measurement of Physical Behaviour}, number = {3}, publisher = {Human Kinetics}, issn = {2575-6605}, doi = {10.1123/jmpb.2018-0063}, pages = {188 -- 196}, year = {2019}, language = {en} } @article{HuberBoireLopezetal.2015, author = {Huber, Florian and Boire, Adeline and L{\´o}pez, Magdalena Preciado and Koenderink, Gijsje H.}, title = {Cytoskeletal crosstalk: when three different personalities team up}, series = {Current Opinion in Cell Biology}, volume = {32}, journal = {Current Opinion in Cell Biology}, publisher = {Elsevier}, issn = {1879-0410}, doi = {10.1016/j.ceb.2014.10.005}, pages = {39 -- 47}, year = {2015}, language = {en} } @article{HuberVerhoevenMeijeretal.2020, author = {Huber, Florian and Verhoeven, Stefan and Meijer, Christiaan and Spreeuw, Hanno and Castilla, Efra{\´i}n and Geng, Cunliang and van der Hooft, Justin J. J. and Rogers, Simon and Belloum, Adam and Diblen, Faruk and Spaaks, Jurriaan H.}, title = {matchms - processing and similarity evaluation of mass spectrometry data}, series = {Journal of Open Source Software}, volume = {5}, journal = {Journal of Open Source Software}, number = {52}, publisher = {Cold Spring Harbor Laboratory}, issn = {2475-9066}, doi = {10.21105/joss.02411}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:due62-opus-34856}, pages = {2411}, year = {2020}, language = {en} } @article{PreciadoLopezHuberGrigorievetal.2014, author = {Preciado L{\´o}pez, Magdalena and Huber, Florian and Grigoriev, Ilya and Steinmetz, Michel O. and Akhmanova, Anna and Dogterom, Marileen and Koenderink, Gijsje H.}, title = {In vitro reconstitution of dynamic microtubules interacting with actin filament networks}, series = {Methods in Enzymology}, volume = {540}, journal = {Methods in Enzymology}, publisher = {Elsevier}, issn = {1557-7988}, doi = {10.1016/B978-0-12-397924-7.00017-0}, pages = {301 -- 320}, year = {2014}, language = {en} } @article{PreciadoLopezHuberGrigorievetal.2014, author = {Preciado L{\´o}pez, Magdalena and Huber, Florian and Grigoriev, Ilya and Steinmetz, Michel O. and Akhmanova, Anna and Koenderink, Gijsje H. and Dogterom, Marileen}, title = {Actin-microtubule coordination at growing microtubule ends}, series = {Nature Communications}, volume = {5}, journal = {Nature Communications}, publisher = {Springer Nature}, issn = {2041-1723}, doi = {10.1038/ncomms5778}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:due62-opus-34878}, pages = {4778}, year = {2014}, abstract = {To power dynamic processes in cells, the actin and microtubule cytoskeletons organize into complex structures. Although it is known that cytoskeletal coordination is vital for cell function, the mechanisms by which cross-linking proteins coordinate actin and microtubule activities remain poorly understood. In particular, it is unknown how the distinct mechanical properties of different actin architectures modulate the outcome of actin-microtubule interactions. To address this question, we engineered the protein TipAct, which links growing microtubule ends via end-binding proteins to actin filaments. We show that growing microtubules can be captured and guided by stiff actin bundles, leading to global actin-microtubule alignment. Conversely, growing microtubule ends can transport, stretch and bundle individual actin filaments, thereby globally defining actin filament organization. Our results provide a physical basis to understand actin-microtubule cross-talk, and reveal that a simple cross-linker can enable a mechanical feedback between actin and microtubule organization that is relevant to diverse biological contexts.}, language = {en} } @article{HuberRidderVerhoevenetal.2021, author = {Huber, Florian and Ridder, Lars and Verhoeven, Stefan and Spaaks, Jurriaan H. and Diblen, Faruk and Rogers, Simon and van der Hooft, Justin J. J.}, title = {Spec2Vec: Improved mass spectral similarity scoring through learning of structural relationships}, series = {PLOS Computational Biology}, volume = {17}, journal = {PLOS Computational Biology}, number = {2}, publisher = {Cold Spring Harbor Laboratory}, issn = {1553-7358}, doi = {10.1371/journal.pcbi.1008724}, url = {http://nbn-resolving.de/urn:nbn:de:hbz:due62-opus-34687}, year = {2021}, abstract = {Spectral similarity is used as a proxy for structural similarity in many tandem mass spectrometry (MS/MS) based metabolomics analyses such as library matching and molecular networking. Although weaknesses in the relationship between spectral similarity scores and the true structural similarities have been described, little development of alternative scores has been undertaken. Here, we introduce Spec2Vec, a novel spectral similarity score inspired by a natural language processing algorithm-Word2Vec. Spec2Vec learns fragmental relationships within a large set of spectral data to derive abstract spectral embeddings that can be used to assess spectral similarities. Using data derived from GNPS MS/MS libraries including spectra for nearly 13,000 unique molecules, we show how Spec2Vec scores correlate better with structural similarity than cosine-based scores. We demonstrate the advantages of Spec2Vec in library matching and molecular networking. Spec2Vec is computationally more scalable allowing structural analogue searches in large databases within seconds.}, language = {en} } @article{GuoDoRuess2019, author = {Guo, Y. and Do, H. and Ruess, Martin}, title = {Isogeometric stability analysis of thin shells: From simple geometries to engineering models}, series = {International Journal for Numerical Methods in Engineering}, volume = {118}, journal = {International Journal for Numerical Methods in Engineering}, number = {8}, publisher = {Wiley}, issn = {1097-0207}, doi = {10.1002/nme.6020}, pages = {433 -- 458}, year = {2019}, language = {en} } @article{JainFranz2004, author = {Jain, V. K. and Franz, J. H.}, title = {Some Design Issues in Infrared Wireless Networks}, series = {IETE Technical Review}, volume = {21}, journal = {IETE Technical Review}, number = {5}, publisher = {Taylor \& Francis}, doi = {10.1080/02564602.2004.11417161}, pages = {335 -- 343}, year = {2004}, language = {en} } @article{PrataDezitterDaviesetal.2016, author = {Prata, A. J. and Dezitter, F. and Davies, I. and Weber, Konradin and Birnfeld, M. and Moriano, D. and Bernardo, C. and Vogel, A. and Prata, G. S. and Mather, T. A. and Thomas, H. E. and Cammas, J. and Weber, M.}, title = {Artificial cloud test confirms volcanic ash detection using infrared spectral imaging}, series = {Scientific reports}, volume = {6}, journal = {Scientific reports}, publisher = {Springer Nature}, doi = {10.1038/srep25620}, year = {2016}, abstract = {Airborne volcanic ash particles are a known hazard to aviation. Currently, there are no means available to detect ash in flight as the particles are too fine (radii < 30 μm) for on-board radar detection and, even in good visibility, ash clouds are difficult or impossible to detect by eye. The economic cost and societal impact of the April/May 2010 Icelandic eruption of Eyjafjallaj{\"o}kull generated renewed interest in finding ways to identify airborne volcanic ash in order to keep airspace open and avoid aircraft groundings. We have designed and built a bi-spectral, fast-sampling, uncooled infrared camera device (AVOID) to examine its ability to detect volcanic ash from commercial jet aircraft at distances of more than 50 km ahead. Here we report results of an experiment conducted over the Atlantic Ocean, off the coast of France, confirming the ability of the device to detect and quantify volcanic ash in an artificial ash cloud created by dispersal of volcanic ash from a second aircraft. A third aircraft was used to measure the ash in situ using optical particle counters. The cloud was composed of very fine ash (mean radii ~10 μm) collected from Iceland immediately after the Eyjafjallaj{\"o}kull eruption and had a vertical thickness of ~200 m, a width of ~2 km and length of between 2 and 12 km. Concentrations of ~200 μg m(-3) were identified by AVOID at distances from ~20 km to ~70 km. For the first time, airborne remote detection of volcanic ash has been successfully demonstrated from a long-range flight test aircraft.}, language = {en} } @inproceedings{DubberkePriebeVrabecetal.2015, author = {Dubberke, Frithjof H. and Priebe, Klaus-Peter and Vrabec, Jadran and Neef, Matthias and R{\"o}dder, Maximilian}, title = {Thermodynamic simulation and experimental validation of a cascaded two-stage organic Rankine cycle}, series = {ASME ORC 2015, Brussels}, booktitle = {ASME ORC 2015, Brussels}, address = {Brussels}, year = {2015}, language = {en} } @article{EversheimBauernhanslDeckertetal.2001, author = {Eversheim, Walter and Bauernhansl, Thomas and Deckert, Carsten and Kampker, Achim and H{\"a}rtung, Stefan and H. von der Ohe, Carsten}, title = {Vom Marktteilnehmer zum Marktgestalter: Innovatives Denken er{\"o}ffnet neue Wachstumsperspektiven im Maschinen- und Anlagenbau}, series = {ZWF Zeitschrift f{\"u}r wirtschaftlichen Fabrikbetrieb}, volume = {96}, journal = {ZWF Zeitschrift f{\"u}r wirtschaftlichen Fabrikbetrieb}, number = {10}, publisher = {Hanser}, doi = {10.3139/104.100475}, pages = {522 -- 524}, year = {2001}, abstract = {Innovative thinking opens up new growth prospects in mechanical and plant engineering. Mechanical and plant engineering has been traditionally very important to the industrial location of Germany [1]. With an export share of 70\%, it has a considerable direct influence on economic structure and job market. In addition, mechanical engineering is the "innovation engine" for other core industries in Germany - as supplier of production equipment for industries such as the car manufacture, plastics processing and electrical engineering sectors. Only through this production equipment can innovative products reach production readiness in the first place, and can "Made in Germany" continue to enjoy an excellent reputation all over the world.}, language = {de} } @article{DubberkeLinnemannAbbasetal.2018, author = {Dubberke, Frithjof H. and Linnemann, Matthias and Abbas, Wameedh Khider and Baumh{\"o}gger, Elmar and Priebe, Klaus-Peter and Roedder, Maximilian and Neef, Matthias and Vrabec, Jadran}, title = {Experimental setup of a cascaded two-stage organic Rankine cycle}, series = {Applied Thermal Engineering}, volume = {131}, journal = {Applied Thermal Engineering}, publisher = {Elsevier}, doi = {10.1016/j.applthermaleng.2017.11.137}, pages = {958 -- 964}, year = {2018}, abstract = {In combination with a bottoming cycle, operated with a pure fluid in transcritical mode, the usage of a zeotropic mixture as a working fluid appears to be exergetically favorable for power cycle efficiency in cascaded two-stage organic Rankine cycles (CORC). A CORC is set up and initially tested with cyclopentane and propane as working fluids in its high temperature and low temperature cycle, respectively. A thermal oil cycle serves as the heat source and is powered electrically with a maximum heat flow of 158 kW. The design of this experimental setup allows for a rapid replacement of individual components and for a wide range of conditions in terms of fluids and thermodynamic states. The components of all cycles and the measurement and control technology are described in detail. A testing procedure is presented, followed by a discussion of the measurement results, where it is shown that the intended concept of two cascaded organic Rankine cycles is operational and that the measured data are consistent.}, language = {en} } @article{NguyenStoterRuessetal.2018, author = {Nguyen, Lam H. and Stoter, Stein K.F. and Ruess, Martin and Sanchez Uribe, Manuel A. and Schillinger, Dominik}, title = {The diffuse Nitsche method: Dirichlet constraints on phase-field boundaries}, series = {International Journal for Numerical Methods in Engineering}, volume = {113}, journal = {International Journal for Numerical Methods in Engineering}, number = {4}, publisher = {Wiley}, issn = {1097-0207}, doi = {10.1002/nme.5628}, pages = {601 -- 633}, year = {2018}, language = {en} }