TY - JOUR A1 - Huber, Florian A1 - Käs, Josef T1 - Self-regulative organization of the cytoskeleton T2 - Cytoskeleton N2 - Despite its impressive complexity the cytoskeleton succeeds to persistently organize itself and thus the cells' interior. In contrast to classical man-made machines, much of the cellular organization originates from inherent self-assembly and self-organization allowing a high degree of autonomy for various functional units. Recent experimental and theoretical studies revealed numerous examples of cytoskeleton components that arrange and organize in a self-regulative way. In the present review we want to shortly summarize some of the principle mechanisms that are able to inherently trigger and regulate the cytoskeleton organization. Although taken individually most of these regulative principles are rather simple with intuitively predictable consequences, combinations of two or more of these mechanisms can quickly give rise to very complex, unexpected behavior and might even be able to explain the formation of different functional units out of a common pool of available building blocks. Y1 - 2011 UR - https://opus4.kobv.de/opus4-hs-duesseldorf/frontdoor/index/index/docId/3479 UR - http://www.ncbi.nlm.nih.gov/pubmed/21438165 SN - 1949-3592 N1 - Acknowledgment We would like to thank Dan Strehle for critical reading ofthis manuscript. This work was funded by the Leipzig School of Natural Sciences ‘‘BuildMoNa’’ as well as bythe Sa¨chsische Aufbaubank project number 13403 VL - 68 IS - 5 SP - 259 EP - 265 PB - Wiley ER -