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Local thermomechanical stress can cause failures in semiconductor packages during long-time operation under harsh environmental conditions. This study helps to explain the packaging-induced stress in blue GaN-LEDs soldered onto copper substrates using AuSn alloy as lead-free interconnect material. Based on the finite element method, a virtual prototype is developed to simulate the thermomechanical behavior and stress in the LED and in the complete LED/AuSn/Cu assembly considering plastic and viscoplastic strain. The investigations were performed by varying the temperature between −50°C and 180°C. To validate the model, the simulation results are compared to experimental data collected with Raman spectroscopy. Studies of the urn:x-wiley:03770486:media:jrs5947:jrs5947-math-0003 phonon mode of GaN semiconductor are elaborated to understand the induced thermomechanical stress. The model enables evaluation of the stress in the interfaces of the assembly, which otherwise cannot be accessed by measurements. It serves to predict how assemblies would perform, before committing resources to build a physical prototype.
If there is something we have learned from the antibiotic era, it is that indiscriminate use of a therapeutic agent without a clear understanding of its long-term evolutionary impact can have enormous health repercussions. This knowledge is particularly relevant when the therapeutic agents are remarkably adaptable and diverse biological entities capable of a plethora of interactions, most of which remain largely unexplored. Although phage therapy (PT) undoubtedly holds the potential to save lives, its current efficacy in case studies recalls the golden era of antibiotics, when these compounds were highly effective and the possibility of them becoming ineffective seemed remote. Safe PT schemes depend on our understanding of how phages interact with, and evolve in, highly complex environments. Here, we summarize and review emerging evidence in a commonly overlooked theme in PT: bacteria-phage interactions. In particular, we discuss the influence of quorum sensing (QS) on phage susceptibility, the consequent role of phages in modulating bacterial cooperation, and the potential implications of this relationship in PT, including how we can use this knowledge to inform PT strategies. We highlight that the influence of QS on phage susceptibility seems to be widespread but can have contrasting outcomes depending on the bacterial host, underscoring the need to thoroughly characterize this link in various bacterial models. Furthermore, we encourage researchers to exploit competition experiments, experimental evolution, and mathematical modeling to explore this relationship further in relevant infection models. Finally, we emphasize that long-term PT success requires research on phage ecology and evolution to inform the design of optimal therapeutic schemes.
In electric vehicles with lithium-ion battery systems, the temperature of the battery cells has a great impact on performance, safety, and lifetime. Therefore, developing thermal models of lithium-ion batteries to predict and investigate the temperature development and its impact is crucial. Commonly, models are validated with experimental data to ensure correct model behaviour. However, influences of experimental setups or comprehensive validation concepts are often not considered, especially for the use case of prismatic cells in a battery electric vehicle. In this work, a 3D electro–thermal model is developed and experimentally validated to predict the cell’s temperature behaviour for a single prismatic cell under battery electric vehicle (BEV) boundary conditions. One focus is on the development of a single cell’s experimental setup and the investigation of the commonly neglected influences of an experimental setup on the cell’s thermal behaviour. Furthermore, a detailed validation is performed for the laboratory BEV scenario for spatially resolved temperatures and heat generation. For validation, static and dynamic loads are considered as well as the detected experimental influences. The validated model is used to predict the temperature within the cell in the BEV application for constant current and Worldwide harmonized Light vehicles Test Procedure (WLTP) load profile.