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In case of concatenated, complex material flow structures such as those in calcium silicate masonry unit plants, plan deviations pose a major challenge for an efficient order processing in production. In order to overcome the separation between the planning and operational levels in traditional production planning and control systems, this paper presents a validated concept to react immediately to critical events while maintaining efficiency using a modular, rolling-reactive optimization tool. A substantial difference to conventional rescheduling models is the intensive integration of event-discrete simulation, which delivers more realistic results and reduces the threat of an obsolete model due to simple modelling.