TY - JOUR A1 - Koellisch, Ulrich A1 - Laustsen, Christoffer A1 - Nørlinger, Thomas S. A1 - Østergaard, Jakob A. A1 - Flyvbjerg, Allan A1 - Gringeri, Concetta V. A1 - Menzel, Marion Irene A1 - Schulte, Rolf F. A1 - Haase, Axel A1 - Stødkilde-Jørgensen, Hans T1 - Current state-of-the-art hyperpolarized 13C-acetate-to-acetylcarnitine imaging is not indicative of the alteredbalance between glucose and fatty acid utilizationassociated with diabetes JF - Physiological Reports UR - https://doi.org/10.14814/phy2.12975 Y1 - 2016 UR - https://doi.org/10.14814/phy2.12975 UR - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:573-44633 SN - 2051-817X N1 - Erratum verfügbar unter DOI "https://doi.org/10.14814/phy2.12999" VL - 4 IS - 17 PB - Wiley CY - New York ER - TY - JOUR A1 - Koellisch, Ulrich A1 - Laustsen, Christoffer A1 - Nørlinger, Thomas S. A1 - Østergaard, Jakob Appel A1 - Flyvbjerg, Allan A1 - Gringeri, Concetta V. A1 - Menzel, Marion Irene A1 - Schulte, Rolf F. A1 - Haase, Axel A1 - Stødkilde-Jørgensen, Hans T1 - Investigation of metabolic changes in STZ-induced diabetic rats with hyperpolarized [1-13C]acetate JF - Physiological Reports N2 - In the metabolism of acetate several enzymes are involved, which play an important role in free fatty acid oxidation. Fatty acid metabolism is altered in diabetes patients and therefore acetate might serve as a marker for pathological changes in the fuel selection of cells, as these changes occur in diabetes patients. Acetylcarnitine is a metabolic product of acetate, which enables its transport into the mitochondria for energy production. This study investigates whether the ratio of acetylcarnitine to acetate, measured by noninvasive hyperpolarized [1-13C]acetate magnetic resonance spectroscopy, could serve as a marker for myocardial, hepatic, and renal metabolic changes in rats with Streptozotocin (STZ)-induced diabetes in vivo. We demonstrate that the conversion of acetate to acetylcarnitine could be detected and quantified in all three organs of interest. More interestingly, we found that the hyperpolarized acetylcarnitine to acetate ratio was independent of blood glucose levels and prolonged hyperglycemia following diabetes induction in a type-1 diabetes model. UR - https://doi.org/10.14814/phy2.12474 Y1 - 2015 UR - https://doi.org/10.14814/phy2.12474 UR - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:573-44529 SN - 2051-817X VL - 3 IS - 8 PB - Wiley CY - Weinheim ER -