TY - JOUR A1 - Gómez Damián, Pedro A. A1 - Sperl, Jonathan I. A1 - Janich, Martin A. A1 - Khegai, Oleksandr A1 - Wiesinger, Florian A1 - Glaser, Steffen J. A1 - Haase, Axel A1 - Schwaiger, Markus A1 - Schulte, Rolf F. A1 - Menzel, Marion Irene T1 - Multisite Kinetic Modeling of 13C Metabolic MR Using [1-13C]Pyruvate JF - Radiology Research and Practice N2 - Hyperpolarized13C imaging allows real-timein vivomeasurements of metabolite levels. Quantification of metabolite conversion between [1-13C]pyruvate and downstream metabolites [1-13C]alanine, [1-13C]lactate, and [13C]bicarbonate can be achieved through kinetic modeling. Since pyruvate interacts dynamically and simultaneously with its downstream metabolites, the purpose of this work is the determination of parameter values through a multisite, dynamic model involving possible biochemical pathways present in MR spectroscopy. Kinetic modeling parameters were determined by fitting the multisite model to time-domain dynamic metabolite data. The results for different pyruvate doses were compared with those of different two-site models to evaluate the hypothesis that for identical data the uncertainty of a model and the signal-to-noise ratio determine the sensitivity in detecting small physiological differences in the target metabolism. In comparison to the two-site exchange models, the multisite model yielded metabolic conversion rates with smaller bias and smaller standard deviation, as demonstrated in simulations with different signal-to-noise ratio. Pyruvate dose effects observed previously were confirmed and quantified through metabolic conversion rate values. Parameter interdependency allowed an accurate quantification and can therefore be useful for monitoring metabolic activity in different tissues. UR - https://doi.org/10.1155/2014/871619 Y1 - 2014 UR - https://doi.org/10.1155/2014/871619 UR - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:573-41646 SN - 2090-195X VL - 2014 PB - Hindawi CY - New York ER - TY - JOUR A1 - Coello, Eduardo A1 - Hafalir, Fatih S. A1 - Noeske, Ralph A1 - Menzel, Marion Irene A1 - Haase, Axel A1 - Menze, Bjoern H. A1 - Schulte, Rolf F. T1 - Overdiscrete echo-planar spectroscopic imaging with correlated higher-order phase correction JF - Magnetic Resonance in Medicine UR - https://doi.org/10.1002/mrm.28105 Y1 - 2019 UR - https://doi.org/10.1002/mrm.28105 SN - 1522-2594 VL - 84 IS - 1 SP - 11 EP - 24 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Pirkl, Carolin A1 - Nunez-Gonzalez, Laura A1 - Kofler, Florian A1 - Endt, Sebastian A1 - Grundl, Lioba A1 - Golbabaee, Mohammad A1 - Gómez, Pedro A. A1 - Cencini, Matteo A1 - Buonincontri, Guido A1 - Schulte, Rolf F. A1 - Smits, Marion A1 - Wiestler, Benedikt A1 - Menze, Bjoern H. A1 - Menzel, Marion Irene A1 - Hernandez-Tamames, Juan A. T1 - Accelerated 3D whole-brain T1, T2, and proton density mapping BT - feasibility for clinical glioma MR imaging JF - Neuroradiology N2 - Purpose: Advanced MRI-based biomarkers offer comprehensive and quantitative information for the evaluation and characterization of brain tumors. In this study, we report initial clinical experience in routine glioma imaging with a novel, fully 3D multiparametric quantitative transient-state imaging (QTI) method for tissue characterization based on T1 and T2 values. Methods: To demonstrate the viability of the proposed 3D QTI technique, nine glioma patients (grade II–IV), with a variety of disease states and treatment histories, were included in this study. First, we investigated the feasibility of 3D QTI (6:25 min scan time) for its use in clinical routine imaging, focusing on image reconstruction, parameter estimation, and contrast-weighted image synthesis. Second, for an initial assessment of 3D QTI-based quantitative MR biomarkers, we performed a ROI-based analysis to characterize T1 and T2 components in tumor and peritumoral tissue. Results: The 3D acquisition combined with a compressed sensing reconstruction and neural network-based parameter inference produced parametric maps with high isotropic resolution (1.125 × 1.125 × 1.125 mm3 voxel size) and whole-brain coverage (22.5 × 22.5 × 22.5 cm3 FOV), enabling the synthesis of clinically relevant T1-weighted, T2-weighted, and FLAIR contrasts without any extra scan time. Our study revealed increased T1 and T2 values in tumor and peritumoral regions compared to contralateral white matter, good agreement with healthy volunteer data, and high inter-subject consistency. Conclusion: 3D QTI demonstrated comprehensive tissue assessment of tumor substructures captured in T1 and T2 parameters. Aiming for fast acquisition of quantitative MR biomarkers, 3D QTI has potential to improve disease characterization in brain tumor patients under tight clinical time-constraints. UR - https://doi.org/10.1007/s00234-021-02703-0 KW - MRI KW - Image-based biomarkers KW - Multiparametric imaging KW - Glioma imaging KW - Neural networks Y1 - 2021 UR - https://doi.org/10.1007/s00234-021-02703-0 UR - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:573-13885 VL - 63 IS - 11 SP - 1831 EP - 1851 PB - Springer CY - Berlin ER - TY - JOUR A1 - Koellisch, Ulrich A1 - Laustsen, Christoffer A1 - Nørlinger, Thomas S. A1 - Østergaard, Jakob A. A1 - Flyvbjerg, Allan A1 - Gringeri, Concetta V. A1 - Menzel, Marion Irene A1 - Schulte, Rolf F. A1 - Haase, Axel A1 - Stødkilde-Jørgensen, Hans T1 - Current state-of-the-art hyperpolarized 13C-acetate-to-acetylcarnitine imaging is not indicative of the alteredbalance between glucose and fatty acid utilizationassociated with diabetes JF - Physiological Reports UR - https://doi.org/10.14814/phy2.12975 Y1 - 2016 UR - https://doi.org/10.14814/phy2.12975 UR - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:573-44633 SN - 2051-817X N1 - Erratum verfügbar unter DOI "https://doi.org/10.14814/phy2.12999" VL - 4 IS - 17 PB - Wiley CY - New York ER - TY - JOUR A1 - Scholz, David Johannes A1 - Janich, Martin A. A1 - Koellisch, Ulrich A1 - Schulte, Rolf F. A1 - Ardenkjaer‐Larsen, Jan H. A1 - Frank, Annette A1 - Haase, Axel A1 - Schwaiger, Markus A1 - Menzel, Marion Irene T1 - Quantified pH imaging with hyperpolarized 13C-bicarbonate JF - Magnetic Resonance in Medicine UR - https://doi.org/10.1002/mrm.25357 Y1 - 2014 UR - https://doi.org/10.1002/mrm.25357 SN - 1522-2594 SN - 0740-3194 VL - 73 IS - 6 SP - 2274 EP - 2282 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Kubala, Eugen A1 - Muñoz-Álvarez, Kim A. A1 - Topping, Geoffrey A1 - Hundshammer, Christian A1 - Feuerecker, Benedikt A1 - Gómez, Pedro A. A1 - Pariani, Giorgio A1 - Schilling, Franz A1 - Glaser, Steffen J. A1 - Schulte, Rolf F. A1 - Menzel, Marion Irene A1 - Schwaiger, Markus T1 - Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging JF - Journal of Visualized Experiments UR - https://doi.org/10.3791/54751 Y1 - 2016 UR - https://doi.org/10.3791/54751 SN - 1940-087X VL - 2016 IS - 118 PB - MyJoVE Corporation CY - Cambridge ER - TY - JOUR A1 - Koellisch, Ulrich A1 - Laustsen, Christoffer A1 - Nørlinger, Thomas S. A1 - Østergaard, Jakob Appel A1 - Flyvbjerg, Allan A1 - Gringeri, Concetta V. A1 - Menzel, Marion Irene A1 - Schulte, Rolf F. A1 - Haase, Axel A1 - Stødkilde-Jørgensen, Hans T1 - Investigation of metabolic changes in STZ-induced diabetic rats with hyperpolarized [1-13C]acetate JF - Physiological Reports N2 - In the metabolism of acetate several enzymes are involved, which play an important role in free fatty acid oxidation. Fatty acid metabolism is altered in diabetes patients and therefore acetate might serve as a marker for pathological changes in the fuel selection of cells, as these changes occur in diabetes patients. Acetylcarnitine is a metabolic product of acetate, which enables its transport into the mitochondria for energy production. This study investigates whether the ratio of acetylcarnitine to acetate, measured by noninvasive hyperpolarized [1-13C]acetate magnetic resonance spectroscopy, could serve as a marker for myocardial, hepatic, and renal metabolic changes in rats with Streptozotocin (STZ)-induced diabetes in vivo. We demonstrate that the conversion of acetate to acetylcarnitine could be detected and quantified in all three organs of interest. More interestingly, we found that the hyperpolarized acetylcarnitine to acetate ratio was independent of blood glucose levels and prolonged hyperglycemia following diabetes induction in a type-1 diabetes model. UR - https://doi.org/10.14814/phy2.12474 Y1 - 2015 UR - https://doi.org/10.14814/phy2.12474 UR - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:573-44529 SN - 2051-817X VL - 3 IS - 8 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Scholz, David Johannes A1 - Otto, Angela M. A1 - Hintermair, Josef A1 - Schilling, Franz A1 - Frank, Annette A1 - Köllisch, Ulrich A1 - Janich, Martin A. A1 - Schulte, Rolf F. A1 - Schwaiger, Markus A1 - Haase, Axel A1 - Menzel, Marion Irene T1 - Parameterization of hyperpolarized 13C-bicarbonate-dissolution dynamic nuclear polarization JF - Magnetic Resonance Materials in Physics, Biology and Medicine UR - https://doi.org/10.1007/s10334-015-0500-9 Y1 - 2015 UR - https://doi.org/10.1007/s10334-015-0500-9 SN - 1352-8661 VL - 28 IS - 6 SP - 591 EP - 598 PB - Springer CY - Heidelberg ER - TY - JOUR A1 - Durst, Markus A1 - Koellisch, Ulrich A1 - Daniele, Valeria A1 - Steiger, Katja A1 - Schwaiger, Markus A1 - Haase, Axel A1 - Menzel, Marion Irene A1 - Schulte, Rolf F. A1 - Aime, Silvio A1 - Reineri, Francesca T1 - Probing lactate secretion in tumours with hyperpolarised NMR JF - NMR in Biomedicine UR - https://doi.org/10.1002/nbm.3574 Y1 - 2016 UR - https://doi.org/10.1002/nbm.3574 SN - 1099-1492 SN - 0952-3480 VL - 29 IS - 8 SP - 1079 EP - 1087 PB - Wiley CY - New York ER - TY - JOUR A1 - Koellisch, Ulrich A1 - Gringeri, Concetta V. A1 - Rancan, Giaime A1 - Farell, Eliane V. A1 - Menzel, Marion Irene A1 - Haase, Axel A1 - Schwaiger, Markus A1 - Schulte, Rolf F. T1 - Metabolic Imaging of Hyperpolarized [1-13C]Acetate and [1-13C]Acetylcarnitine - Investigation of the Influence of Dobutamine Induced Stress JF - Magnetic Resonance in Medicine UR - https://doi.org/10.1002/mrm.25485 Y1 - 2014 UR - https://doi.org/10.1002/mrm.25485 SN - 1522-2594 SN - 0740-3194 VL - 74 IS - 4 SP - 1011 EP - 1018 PB - Wiley CY - Hoboken ER -