TY - JOUR A1 - Endt, Sebastian A1 - Engel, Maria A1 - Naldi, Emanuele A1 - Assereto, Rodolfo A1 - Molendowska, Malwina A1 - Mueller, Lars A1 - Verdun, Claudio Mayrink A1 - Pirkl, Carolin A1 - Palombo, Marco A1 - Jones, Derek K. A1 - Menzel, Marion Irene T1 - In Vivo Myelin Water Quantification Using Diffusion–Relaxation Correlation MRI: A Comparison of 1D and 2D Methods JF - Applied Magnetic Resonance N2 - Multidimensional Magnetic Resonance Imaging (MRI) is a versatile tool for microstructure mapping. We use a diffusion weighted inversion recovery spin echo (DW-IR-SE) sequence with spiral readouts at ultra-strong gradients to acquire a rich diffusion–relaxation data set with sensitivity to myelin water. We reconstruct 1D and 2D spectra with a two-step convex optimization approach and investigate a variety of multidimensional MRI methods, including 1D multi-component relaxometry, 1D multi-component diffusometry, 2D relaxation correlation imaging, and 2D diffusion-relaxation correlation spectroscopic imaging (DR-CSI), in terms of their potential to quantify tissue microstructure, including the myelin water fraction (MWF). We observe a distinct spectral peak that we attribute to myelin water in multi-component T1 relaxometry, T1-T2 correlation, T1-D correlation, and T2-D correlation imaging. Due to lower achievable echo times compared to diffusometry, MWF maps from relaxometry have higher quality. Whilst 1D multi-component T1 data allows much faster myelin mapping, 2D approaches could offer unique insights into tissue microstructure and especially myelin diffusion. UR - https://doi.org/10.1007/s00723-023-01584-1 KW - MWF mapping KW - Microstructure KW - Relaxometry KW - Diffusometry KW - Multi-component KW - Multidimensional KW - Multi-exponential KW - Multiparametric KW - Correlation imaging Y1 - 2023 UR - https://doi.org/10.1007/s00723-023-01584-1 UR - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:573-40317 SN - 0937-9347 SN - 1613-7507 VL - 54 IS - 11-12 SP - 1571 EP - 1588 PB - Springer CY - Wien ER -