TY - JOUR A1 - Anderl-Straub, Sarah A1 - Lausser, Ludwig A1 - Lombardi, Jolina A1 - Uttner, Ingo A1 - Fassbender, Klaus A1 - Fliessbach, Klaus A1 - Huppertz, Hans-Jürgen A1 - Jahn, Holger A1 - Kornhuber, Johannes A1 - Obrig, Hellmuth A1 - Schneider, Anja A1 - Semler, Elisa A1 - Synofzik, Matthis A1 - Danek, Adrian A1 - Prudlo, Johannes A1 - Kassubek, Jan A1 - Landwehrmeyer, Bernhard A1 - Lauer, Martin A1 - Volk, Alexander E. A1 - Wiltfang, Jens A1 - Diehl-Schmid, Janine A1 - Ludolph, Albert C. A1 - Schroeter, Matthias A1 - Kestler, Hans A. A1 - Otto, Markus T1 - Predicting disease progression in behavioral variant frontotemporal dementia JF - Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring N2 - Introduction The behavioral variant of frontotemporal dementia (bvFTD) is a rare neurodegenerative disease. Reliable predictors of disease progression have not been sufficiently identified. We investigated multivariate magnetic resonance imaging (MRI) biomarker profiles for their predictive value of individual decline. Methods One hundred five bvFTD patients were recruited from the German frontotemporal lobar degeneration (FTLD) consortium study. After defining two groups (“fast progressors” vs. “slow progressors”), we investigated the predictive value of MR brain volumes for disease progression rates performing exhaustive screenings with multivariate classification models. Results We identified areas that predict disease progression rate within 1 year. Prediction measures revealed an overall accuracy of 80% across our 50 top classification models. Especially the pallidum, middle temporal gyrus, inferior frontal gyrus, cingulate gyrus, middle orbitofrontal gyrus, and insula occurred in these models. Discussion Based on the revealed marker combinations an individual prognosis seems to be feasible. This might be used in clinical studies on an individualized progression model. UR - https://doi.org/10.1002/dad2.12262 KW - behavioral variant frontotemporal dementia KW - brain volume KW - classification models KW - disease progression KW - frontotemporal dementia KW - prognosis Y1 - 2021 UR - https://doi.org/10.1002/dad2.12262 UR - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:573-27212 SN - 2352-8729 N1 - Collaborators FTLD consortium: Christine v. Arnim, Petra Steinacker, Georg Grön, Manuel Maler, Maryna Polyakova, Christopher Weise, Lea Hüper, Daniele Pino, Annerose Engel, Johannes Levin, Catharina Prix, Elisabeth Wlasich, Lina Riedl, Felix Müller-Sarnowski, Carola Roßmeier, Felix Oberhauser, Kai Schumacher, Jan Lehmbeck, Thomas Duning, Andreas Johnen. VL - 13 IS - 1 PB - Alzheimer’s Association CY - Chicago ER -