TY - JOUR A1 - Schulze, Ralf A1 - Szentmiklósi, László A1 - Kudejova, Petra A1 - Canella, Lea A1 - Kis, Zoltán A1 - Belgya, Tamás A1 - Jolie, Jan A1 - Ebert, Martin A1 - Materna, Thomas A1 - Biró, Katalin T. A1 - Hajnal, Zsuzsa T1 - The ANCIENT CHARM project at FRM II BT - three-dimensional elemental mapping by prompt gamma activation imaging and neutron tomography JF - Journal of Analytical Atomic Spectrometry UR - https://doi.org/10.1039/C3JA50162K Y1 - 2013 UR - https://doi.org/10.1039/C3JA50162K SN - 1364-5544 VL - 28 IS - 9 SP - 1508 EP - 1512 PB - ChemSoc CY - Cambridge ER - TY - JOUR A1 - Anderl-Straub, Sarah A1 - Lausser, Ludwig A1 - Lombardi, Jolina A1 - Uttner, Ingo A1 - Fassbender, Klaus A1 - Fliessbach, Klaus A1 - Huppertz, Hans-Jürgen A1 - Jahn, Holger A1 - Kornhuber, Johannes A1 - Obrig, Hellmuth A1 - Schneider, Anja A1 - Semler, Elisa A1 - Synofzik, Matthis A1 - Danek, Adrian A1 - Prudlo, Johannes A1 - Kassubek, Jan A1 - Landwehrmeyer, Bernhard A1 - Lauer, Martin A1 - Volk, Alexander E. A1 - Wiltfang, Jens A1 - Diehl-Schmid, Janine A1 - Ludolph, Albert C. A1 - Schroeter, Matthias A1 - Kestler, Hans A. A1 - Otto, Markus T1 - Predicting disease progression in behavioral variant frontotemporal dementia JF - Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring N2 - Introduction The behavioral variant of frontotemporal dementia (bvFTD) is a rare neurodegenerative disease. Reliable predictors of disease progression have not been sufficiently identified. We investigated multivariate magnetic resonance imaging (MRI) biomarker profiles for their predictive value of individual decline. Methods One hundred five bvFTD patients were recruited from the German frontotemporal lobar degeneration (FTLD) consortium study. After defining two groups (“fast progressors” vs. “slow progressors”), we investigated the predictive value of MR brain volumes for disease progression rates performing exhaustive screenings with multivariate classification models. Results We identified areas that predict disease progression rate within 1 year. Prediction measures revealed an overall accuracy of 80% across our 50 top classification models. Especially the pallidum, middle temporal gyrus, inferior frontal gyrus, cingulate gyrus, middle orbitofrontal gyrus, and insula occurred in these models. Discussion Based on the revealed marker combinations an individual prognosis seems to be feasible. This might be used in clinical studies on an individualized progression model. UR - https://doi.org/10.1002/dad2.12262 KW - behavioral variant frontotemporal dementia KW - brain volume KW - classification models KW - disease progression KW - frontotemporal dementia KW - prognosis Y1 - 2021 UR - https://doi.org/10.1002/dad2.12262 UR - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:573-27212 SN - 2352-8729 N1 - Collaborators FTLD consortium: Christine v. Arnim, Petra Steinacker, Georg Grön, Manuel Maler, Maryna Polyakova, Christopher Weise, Lea Hüper, Daniele Pino, Annerose Engel, Johannes Levin, Catharina Prix, Elisabeth Wlasich, Lina Riedl, Felix Müller-Sarnowski, Carola Roßmeier, Felix Oberhauser, Kai Schumacher, Jan Lehmbeck, Thomas Duning, Andreas Johnen. VL - 13 IS - 1 PB - Alzheimer’s Association CY - Chicago ER - TY - JOUR A1 - Prud'homme, Dan A1 - von Zedtwitz, Max A1 - Thraen, Joachim Jan A1 - Bader, Martin T1 - “Forced technology transfer” policies: Workings in China and strategic implications JF - Technological Forecasting and Social Change UR - https://doi.org/10.1016/j.techfore.2018.05.022 Y1 - 2018 UR - https://doi.org/10.1016/j.techfore.2018.05.022 SN - 1873-5509 SN - 0040-1625 VL - 2018 IS - 134 SP - 150 EP - 168 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Scholz, David Johannes A1 - Janich, Martin A. A1 - Koellisch, Ulrich A1 - Schulte, Rolf F. A1 - Ardenkjaer‐Larsen, Jan H. A1 - Frank, Annette A1 - Haase, Axel A1 - Schwaiger, Markus A1 - Menzel, Marion Irene T1 - Quantified pH imaging with hyperpolarized 13C-bicarbonate JF - Magnetic Resonance in Medicine UR - https://doi.org/10.1002/mrm.25357 Y1 - 2014 UR - https://doi.org/10.1002/mrm.25357 SN - 1522-2594 SN - 0740-3194 VL - 73 IS - 6 SP - 2274 EP - 2282 PB - Wiley CY - Hoboken ER -