TY - CHAP A1 - Bader, Martin A1 - Gassmann, Oliver ED - Thouvenin, Florent ED - Wildhaber, Isabelle T1 - Management von Technologietransfer T2 - Technologietransfer: Möglichkeiten und Grenzen rechtlicher Gestaltung, Referate der Tagung vom 30. November 2011 in St.Gallen Y1 - 2012 SN - 978-3-906049-02-1 SP - 9 EP - 29 PB - Institut für Rechtswissenschaft und Rechtspraxis CY - St. Gallen ER - TY - BOOK A1 - Gassmann, Oliver A1 - Bader, Martin T1 - Patentmanagement BT - Innovationen erfolgreich nutzen und schützen UR - https://doi.org/10.1007/3-540-30039-2 Y1 - 2006 UR - https://doi.org/10.1007/3-540-30039-2 SN - 978-3-540-30039-7 SN - 978-3-540-23554-5 PB - Springer CY - Berlin ER - TY - BOOK A1 - Gassmann, Oliver A1 - Bader, Martin T1 - Patentmanagement BT - Innovationen erfolgreich nutzen und schützen UR - https://doi.org/10.1007/978-3-662-49527-8 Y1 - 2017 UR - https://doi.org/10.1007/978-3-662-49527-8 SN - 978-3-662-49527-8 PB - Springer Gabler CY - Berlin ET - 4., vollständig überarbeitete und erweiterte Auflage ER - TY - BOOK A1 - Gassmann, Oliver A1 - Bader, Martin T1 - Patentmanagement BT - Innovationen erfolgreich nutzen und schützen UR - https://doi.org/10.1007/978-3-642-16605-1 Y1 - 2011 UR - https://doi.org/10.1007/978-3-642-16605-1 SN - 978-3-642-16605-1 PB - Springer CY - Berlin ET - Dritte, vollständig überarbeitete und erweiterte Auflage ER - TY - BOOK A1 - Gassmann, Oliver A1 - Bader, Martin T1 - Patentmanagement BT - Innovationen erfolgreich nutzen und schützen UR - https://doi.org/10.1007/978-3-540-68973-7 Y1 - 2007 UR - https://doi.org/10.1007/978-3-540-68973-7 SN - 978-3-540-68973-7 PB - Springer CY - Berlin ET - Zweite, aktualisierte Auflage ER - TY - JOUR A1 - Bonakdar, Amir A1 - Frankenberger, Karolin A1 - Bader, Martin A1 - Gassmann, Oliver T1 - Capturing value from business models: the role of formal and informal protection strategies JF - International Journal of Technology Management UR - https://doi.org/10.1504/IJTM.2017.083073 KW - business models KW - business model innovation KW - intellectual property management KW - IPM KW - value capture KW - formal strategies KW - informal strategies KW - IP protection strategies KW - profiting from innovation Y1 - 2017 UR - https://doi.org/10.1504/IJTM.2017.083073 SN - 1741-5276 VL - 73 IS - 4 SP - 151 EP - 175 PB - Inderscience CY - Cointrin ER - TY - BOOK A1 - Gassmann, Oliver A1 - Bader, Martin A1 - Thompson, Mark James T1 - Patent Management BT - Protecting Intellectual Property and Innovation T3 - Management for Professionals UR - https://doi.org/10.1007/978-3-030-59009-3 KW - Patent management KW - Intellectual property management KW - Protecting innovation KW - Patents and regulation KW - Intellectual property rights KW - Patent law Y1 - 2021 UR - https://doi.org/10.1007/978-3-030-59009-3 SN - 978-3-030-59009-3 SN - 978-3-030-59008-6 PB - Springer CY - Cham ER - TY - BOOK A1 - Gassmann, Oliver A1 - Bader, Martin T1 - Patentmanagement BT - Innovationen erfolgreich nutzen und schützen UR - https://doi.org/10.1007/978-3-662-68488-7 Y1 - 2024 UR - https://doi.org/10.1007/978-3-662-68488-7 SN - 978-3-662-68488-7 SN - 978-3-662-68487-0 PB - Springer CY - Berlin ET - 5., vollständig überarbeitete und erweiterte Auflage ER - TY - CHAP A1 - Bader, Martin A1 - Gassmann, Oliver ED - Gassmann, Oliver ED - Ferrandina, Fabrizio T1 - Patent Strategies in the Networked Economy T2 - Connected Business: Create Value in a Networked Economy UR - https://doi.org/10.1007/978-3-030-76897-3_14 Y1 - 2021 UR - https://doi.org/10.1007/978-3-030-76897-3_14 SN - 978-3-030-76897-3 SN - 978-3-030-76896-6 SP - 247 EP - 264 PB - Springer CY - Cham ER - TY - BOOK A1 - Gassmann, Oliver A1 - Schuhmacher, Alexander A1 - von Zedtwitz, Max A1 - Reepmeyer, Gerrit T1 - Führung und Organisation pharmazeutischer Innovation BT - Wie man den Wettlauf der Life Sciences gewinnt UR - https://doi.org/10.1007/978-3-031-43818-9 Y1 - 2024 UR - https://doi.org/10.1007/978-3-031-43818-9 SN - 978-3-031-43818-9 SN - 978-3-031-43817-2 PB - Springer Gabler CY - Cham ER - TY - JOUR A1 - Schuhmacher, Alexander A1 - Gassmann, Oliver A1 - Hinder, Markus T1 - Changing R&D models in research-based pharmaceutical companies JF - Journal of Translational Medicine N2 - New drugs serving unmet medical needs are one of the key value drivers of research-based pharmaceutical companies. The efficiency of research and development (R&D), defined as the successful approval and launch of new medicines (output) in the rate of the monetary investments required for R&D (input), has declined since decades. We aimed to identify, analyze and describe the factors that impact the R&D efficiency. Based on publicly available information, we reviewed the R&D models of major research-based pharmaceutical companies and analyzed the key challenges and success factors of a sustainable R&D output. We calculated that the R&D efficiencies of major research-based pharmaceutical companies were in the range of USD 3.2–32.3 billion (2006–2014). As these numbers challenge the model of an innovation-driven pharmaceutical industry, we analyzed the concepts that companies are following to increase their R&D efficiencies: (A) Activities to reduce portfolio and project risk, (B) activities to reduce R&D costs, and (C) activities to increase the innovation potential. While category A comprises measures such as portfolio management and licensing, measures grouped in category B are outsourcing and risk-sharing in late-stage development. Companies made diverse steps to increase their innovation potential and open innovation, exemplified by open source, innovation centers, or crowdsourcing, plays a key role in doing so. In conclusion, research-based pharmaceutical companies need to be aware of the key factors, which impact the rate of innovation, R&D cost and probability of success. Depending on their company strategy and their R&D set-up they can opt for one of the following open innovators: knowledge creator, knowledge integrator or knowledge leverager. UR - https://doi.org/10.1186/s12967-016-0838-4 Y1 - 2016 UR - https://doi.org/10.1186/s12967-016-0838-4 UR - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:573-53816 SN - 1479-5876 VL - 14 PB - BioMed Central CY - London ER - TY - JOUR A1 - Schuhmacher, Alexander A1 - Gassmann, Oliver A1 - McCracken, Nigel A1 - Hinder, Markus T1 - Open innovation and external sources of innovation. An opportunity to fuel the R&D pipeline and enhance decision making? JF - Journal of Translational Medicine N2 - Historically, research and development (R&D) in the pharmaceutical sector has predominantly been an in-house activity. To enable investments for game changing late-stage assets and to enable better and less costly go/no-go decisions, most companies have employed a fail early paradigm through the implementation of clinical proof-of-concept organizations. To fuel their pipelines, some pioneers started to complement their internal R&D efforts through collaborations as early as the 1990s. In recent years, multiple extrinsic and intrinsic factors induced an opening for external sources of innovation and resulted in new models for open innovation, such as open sourcing, crowdsourcing, public–private partnerships, innovations centres, and the virtualization of R&D. Three factors seem to determine the breadth and depth regarding how companies approach external innovation: (1) the company’s legacy, (2) the company’s willingness and ability to take risks and (3) the company’s need to control IP and competitors. In addition, these factors often constitute the major hurdles to effectively leveraging external opportunities and assets. Conscious and differential choices of the R&D and business models for different companies and different divisions in the same company seem to best allow a company to fully exploit the potential of both internal and external innovations. UR - https://doi.org/10.1186/s12967-018-1499-2 Y1 - 2018 UR - https://doi.org/10.1186/s12967-018-1499-2 UR - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:573-53862 SN - 1479-5876 VL - 16 IS - 1 PB - BioMed Central CY - London ER - TY - BOOK A1 - Gassmann, Oliver A1 - Schuhmacher, Alexander A1 - von Zedtwitz, Max A1 - Reepmeyer, Gerrit T1 - Leading Pharmaceutical Innovation BT - How to Win the Life Science Race UR - https://doi.org/10.1007/978-3-319-66833-8 Y1 - 2018 UR - https://doi.org/10.1007/978-3-319-66833-8 SN - 978-3-319-66833-8 SN - 978-3-319-66832-1 PB - Springer CY - Cham ET - Third Edition ER - TY - CHAP A1 - Schuhmacher, Alexander A1 - Gassmann, Oliver A1 - Hinder, Markus ED - Schuhmacher, Alexander ED - Hinder, Markus ED - Gassmann, Oliver T1 - A Review of the Pharmaceutical R&D Efficiency: Costs, Timelines, and Probabilities T2 - Value Creation in the Pharmaceutical Industry: The Critical Path to Innovation UR - https://doi.org/10.1002/9783527693405.ch4 Y1 - 2016 UR - https://doi.org/10.1002/9783527693405.ch4 SN - 978-3-527-69343-6 SN - 978-3-527-33913-6 SP - 61 EP - 79 PB - Wiley CY - Weinheim ER - TY - CHAP A1 - Bader, Martin A1 - Gassmann, Oliver ED - Hinder, Markus ED - Schuhmacher, Alexander ED - Goldhahn, Jörg ED - Hartl, Dominik T1 - Patents in the Biomedical Sciences and Industry – The Case of the Swiss Life Science Company Prionics T2 - Principles of Biomedical Sciences and Industry: Translating Ideas into Treatments UR - https://doi.org/10.1002/9783527824014.ch16 Y1 - 2022 UR - https://doi.org/10.1002/9783527824014.ch16 SN - 978-3-527-34571-7 SN - 978-3-527-82401-4 SP - 305 EP - 315 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Schuhmacher, Alexander A1 - Hinder, Markus A1 - Boger, Nikolaj A1 - Hartl, Dominik A1 - Gassmann, Oliver T1 - The significance of blockbusters in the pharmaceutical industry JF - Nature Reviews Drug Discovery UR - https://doi.org/10.1038/d41573-022-00213-z Y1 - 2022 UR - https://doi.org/10.1038/d41573-022-00213-z SN - 1474-1784 VL - 22 IS - 3 SP - 177 EP - 178 PB - Springer Nature CY - London ER - TY - JOUR A1 - Schuhmacher, Alexander A1 - Brieke, Clara A1 - Gassmann, Oliver A1 - Hinder, Markus A1 - Hartl, Dominik T1 - Systematic risk identification and assessment using a new risk map in pharmaceutical R&D JF - Drug Discovery Today UR - https://doi.org/10.1016/j.drudis.2021.06.015 Y1 - 2021 UR - https://doi.org/10.1016/j.drudis.2021.06.015 SN - 1878-5832 SN - 1359-6446 VL - 26 IS - 12 SP - 2786 EP - 2793 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Schuhmacher, Alexander A1 - Hinder, Markus A1 - Brief, Elazar A1 - Gassmann, Oliver A1 - Hartl, Dominik T1 - Benchmarking R&D success rates of leading pharmaceutical companies: an empirical analysis of FDA approvals (2006–2022) JF - Drug Discovery Today N2 - Previous analyses provide an industry benchmark of ∼10% for the success rate in clinical development. However, prior analyses were limited by a narrow timeframe, a diverse research focus, biases in phase-to-phase transition methodology or a focus on specific use cases. We calculated unbiased input:output ratios (Phase I to FDA new drug approval) to analyze the likelihood of first approval using data from clinicaltrials.gov, encompassing a total of 2092 active ingredients, 19 927 clinical trials conducted by 18 leading pharmaceutical companies (2006–2022) and 274 new drug approvals. Our study reveals an average likelihood of first approval rate of 14.3% across leading research-based pharmaceutical companies, broadly ranging from 8% to 23%. UR - https://doi.org/10.1016/j.drudis.2025.104291 Y1 - 2025 UR - https://doi.org/10.1016/j.drudis.2025.104291 UR - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:573-56382 SN - 1878-5832 N1 - Corrigendum verfügbar unter https://doi.org/10.1016/j.drudis.2025.104326 VL - 30 IS - 2 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Schuhmacher, Alexander A1 - Gassmann, Oliver A1 - Hinder, Markus A1 - Kuss, Michael T1 - The present and future of project management in pharmaceutical R&D JF - Drug Discovery Today UR - https://doi.org/10.1016/j.drudis.2020.07.020 Y1 - 2021 UR - https://doi.org/10.1016/j.drudis.2020.07.020 SN - 1878-5832 VL - 26 IS - 1 SP - 1 EP - 4 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Schuhmacher, Alexander A1 - Grinchenko, Kyrylo A1 - Gassmann, Oliver A1 - Hartl, Dominik A1 - Hinder, Markus T1 - A case study assessing the impact of M&A and licensing on FDA drug approvals of leading pharmaceutical companies JF - Drug Discovery Today N2 - Despite a recent increase in FDA new drug approvals, leading pharmaceutical companies continue to face R&D productivity challenges. This highlights the need to better understand the context of their R&D concepts and related R&D outputs. Consequently, we conducted a systematic assessment of the impact of R&D expenditures, R&D intensities, mergers & acquisitions (M&A) deals and licensing agreements on new drug approvals of leading pharmaceutical companies between 2012 and 2021. Our analysis provides key insights into differentiating R&D factors: whereas R&D expenditures and the number of M&A deals correlate with the number of new drug approvals, our analysis shows no correlation with R&D intensity or the number of licensing agreements. UR - https://doi.org/10.1016/j.drudis.2025.104306 Y1 - 2025 UR - https://doi.org/10.1016/j.drudis.2025.104306 UR - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:573-57756 SN - 1878-5832 VL - 30 IS - 3 PB - Elsevier CY - Amsterdam ER -