TY - CHAP A1 - Pirkl, Carolin A1 - Cencini, Matteo A1 - Kurzawski, Jan W. A1 - Waldmannstetter, Diana A1 - Li, Hongwei A1 - Sekuboyina, Anjany A1 - Endt, Sebastian A1 - Peretti, Luca A1 - Donatelli, Graziella A1 - Pasquariello, Rosa A1 - Costagli, Mauro A1 - Buonincontri, Guido A1 - Tosetti, Michela A1 - Menzel, Marion Irene A1 - Menze, Bjoern H. T1 - Residual learning for 3D motion corrected quantitative MRI BT - Robust clinical T1, T2 and proton density mapping T2 - Medical Imaging with Deep Learning MIDL 2021 KW - 3D multiparametric MRI KW - motion correction KW - deep learning KW - residual learning KW - multiscale CNN Y1 - 2021 UR - https://openreview.net/forum?id=hxgQM71AuRA PB - OpenReview ER - TY - JOUR A1 - Endt, Sebastian A1 - Engel, Maria A1 - Naldi, Emanuele A1 - Assereto, Rodolfo A1 - Molendowska, Malwina A1 - Mueller, Lars A1 - Verdun, Claudio A1 - Pirkl, Carolin A1 - Palombo, Marco A1 - Jones, Derek K. A1 - Menzel, Marion Irene T1 - In Vivo Myelin Water Quantification Using Diffusion–Relaxation Correlation MRI: A Comparison of 1D and 2D Methods JF - Applied Magnetic Resonance N2 - Multidimensional Magnetic Resonance Imaging (MRI) is a versatile tool for microstructure mapping. We use a diffusion weighted inversion recovery spin echo (DW-IR-SE) sequence with spiral readouts at ultra-strong gradients to acquire a rich diffusion–relaxation data set with sensitivity to myelin water. We reconstruct 1D and 2D spectra with a two-step convex optimization approach and investigate a variety of multidimensional MRI methods, including 1D multi-component relaxometry, 1D multi-component diffusometry, 2D relaxation correlation imaging, and 2D diffusion-relaxation correlation spectroscopic imaging (DR-CSI), in terms of their potential to quantify tissue microstructure, including the myelin water fraction (MWF). We observe a distinct spectral peak that we attribute to myelin water in multi-component T1 relaxometry, T1-T2 correlation, T1-D correlation, and T2-D correlation imaging. Due to lower achievable echo times compared to diffusometry, MWF maps from relaxometry have higher quality. Whilst 1D multi-component T1 data allows much faster myelin mapping, 2D approaches could offer unique insights into tissue microstructure and especially myelin diffusion. UR - https://doi.org/10.1007/s00723-023-01584-1 KW - MWF mapping KW - Microstructure KW - Relaxometry KW - Diffusometry KW - Multi-component KW - Multidimensional KW - Multi-exponential KW - Multiparametric KW - Correlation imaging Y1 - 2023 UR - https://doi.org/10.1007/s00723-023-01584-1 UR - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:573-40317 SN - 0937-9347 SN - 1613-7507 N1 - Der Nachweis einer Preprint-Version dieser Veröffentlichung ist ebenfalls in diesem Repositorium verzeichnet, s. https://opus4.kobv.de/opus4-haw/frontdoor/index/index/docId/4644 VL - 54 IS - 11-12 SP - 1571 EP - 1588 PB - Springer CY - Wien ER - TY - INPR A1 - Pirkl, Carolin A1 - Gómez, Pedro A. A1 - Lipp, Ilona A1 - Buonincontri, Guido A1 - Molina-Romero, Miguel A1 - Sekuboyina, Anjany A1 - Waldmannstetter, Diana A1 - Dannenberg, Jonathan A1 - Endt, Sebastian A1 - Merola, Alberto A1 - Whittaker, Joseph R. A1 - Tomassini, Valentina A1 - Tosetti, Michela A1 - Jones, Derek K. A1 - Menze, Bjoern H. A1 - Menzel, Marion Irene T1 - Deep learning-based parameter mapping for joint relaxation and diffusion tensor MR Fingerprinting UR - https://doi.org/10.48550/arXiv.2005.02020 Y1 - 2020 UR - https://doi.org/10.48550/arXiv.2005.02020 N1 - Die veröffentlichte Version dieses Preprints ist ebenfalls in diesem Repositorium verzeichnet, s. https://opus4.kobv.de/opus4-haw/frontdoor/index/index/docId/2817 PB - arXiv CY - Ithaca ER - TY - CHAP A1 - Pirkl, Carolin A1 - Gómez, Pedro A. A1 - Lipp, Ilona A1 - Buonincontri, Guido A1 - Molina-Romero, Miguel A1 - Sekuboyina, Anjany A1 - Waldmannstetter, Diana A1 - Dannenberg, Jonathan A1 - Endt, Sebastian A1 - Merola, Alberto A1 - Whittaker, Joseph R. A1 - Tomassini, Valentina A1 - Tosetti, Michela A1 - Jones, Derek K. A1 - Menze, Bjoern H. A1 - Menzel, Marion Irene T1 - Deep learning-based parameter mapping for joint relaxation and diffusion tensor MR Fingerprinting T2 - Proceedings of Machine Learning Research KW - Magnetic Resonance Fingerprinting KW - Convolutional Neural Network KW - Image Reconstruction KW - Diffusion Tensor KW - Multiple Sclerosis Y1 - 2020 UR - https://proceedings.mlr.press/v121/pirk20a.html SN - 2640-3498 N1 - Der Nachweis einer Preprint-Version dieser Veröffentlichung ist ebenfalls in diesem Repositorium verzeichnet, s. https://opus4.kobv.de/opus4-haw/frontdoor/index/index/docId/4468 IS - 121 SP - 639 EP - 654 PB - PMLR CY - [s. l.] ER - TY - CHAP A1 - Pirkl, Carolin A1 - Cencini, Matteo A1 - Kurzawski, Jan W. A1 - Waldmannstetter, Diana A1 - Li, Hongwei A1 - Sekuboyina, Anjany A1 - Endt, Sebastian A1 - Peretti, Luca A1 - Donatelli, Graziella A1 - Pasquariello, Rosa A1 - Costagli, Mauro A1 - Buonincontri, Guido A1 - Tosetti, Michela A1 - Menzel, Marion Irene A1 - Menze, Bjoern H. T1 - Residual learning for 3D motion corrected quantitative MRI: Robust clinical T1, T2 and proton density mapping T2 - Proceedings of Machine Learning Research Y1 - 2021 UR - https://proceedings.mlr.press/v143/pirkl21a.html SP - 618 EP - 632 PB - PMLR CY - [s. l.] ER - TY - JOUR A1 - Pirkl, Carolin A1 - Nunez-Gonzalez, Laura A1 - Kofler, Florian A1 - Endt, Sebastian A1 - Grundl, Lioba A1 - Golbabaee, Mohammad A1 - Gómez, Pedro A. A1 - Cencini, Matteo A1 - Buonincontri, Guido A1 - Schulte, Rolf F. A1 - Smits, Marion A1 - Wiestler, Benedikt A1 - Menze, Bjoern H. A1 - Menzel, Marion Irene A1 - Hernandez-Tamames, Juan A. T1 - Accelerated 3D whole-brain T1, T2, and proton density mapping BT - feasibility for clinical glioma MR imaging JF - Neuroradiology N2 - Purpose: Advanced MRI-based biomarkers offer comprehensive and quantitative information for the evaluation and characterization of brain tumors. In this study, we report initial clinical experience in routine glioma imaging with a novel, fully 3D multiparametric quantitative transient-state imaging (QTI) method for tissue characterization based on T1 and T2 values. Methods: To demonstrate the viability of the proposed 3D QTI technique, nine glioma patients (grade II–IV), with a variety of disease states and treatment histories, were included in this study. First, we investigated the feasibility of 3D QTI (6:25 min scan time) for its use in clinical routine imaging, focusing on image reconstruction, parameter estimation, and contrast-weighted image synthesis. Second, for an initial assessment of 3D QTI-based quantitative MR biomarkers, we performed a ROI-based analysis to characterize T1 and T2 components in tumor and peritumoral tissue. Results: The 3D acquisition combined with a compressed sensing reconstruction and neural network-based parameter inference produced parametric maps with high isotropic resolution (1.125 × 1.125 × 1.125 mm3 voxel size) and whole-brain coverage (22.5 × 22.5 × 22.5 cm3 FOV), enabling the synthesis of clinically relevant T1-weighted, T2-weighted, and FLAIR contrasts without any extra scan time. Our study revealed increased T1 and T2 values in tumor and peritumoral regions compared to contralateral white matter, good agreement with healthy volunteer data, and high inter-subject consistency. Conclusion: 3D QTI demonstrated comprehensive tissue assessment of tumor substructures captured in T1 and T2 parameters. Aiming for fast acquisition of quantitative MR biomarkers, 3D QTI has potential to improve disease characterization in brain tumor patients under tight clinical time-constraints. UR - https://doi.org/10.1007/s00234-021-02703-0 KW - MRI KW - Image-based biomarkers KW - Multiparametric imaging KW - Glioma imaging KW - Neural networks Y1 - 2021 UR - https://doi.org/10.1007/s00234-021-02703-0 UR - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:573-13885 VL - 63 IS - 11 SP - 1831 EP - 1851 PB - Springer CY - Berlin ER - TY - INPR A1 - Endt, Sebastian A1 - Engel, Maria A1 - Naldi, Emanuele A1 - Assereto, Rodolfo A1 - Molendowska, Malwina A1 - Mueller, Lars A1 - Verdun, Claudio A1 - Pirkl, Carolin A1 - Palombo, Marco A1 - Jones, Derek K. A1 - Menzel, Marion Irene T1 - In-vivo myelin water quantification using diffusion-relaxation correlation MRI: a comparison of 1D and 2D methods T2 - Research Square N2 - Multidimensional Magnetic Resonance Imaging (MRI) is a versatile tool for microstructure mapping. We use a diffusion weighted inversion-recovery spin echo (DW-IR-SE) sequence with spiral readouts at ultra-strong gradients to acquire a rich diffusion-relaxation data set with sensitivity to myelin water. We reconstruct 1D and 2D spectra with a two-step convex optimization approach and investigate a variety of multidimensional MRI methods, including 1D multi-component relaxometry, 1D multi-component diffusometry, 2D relaxation correlation imaging, and 2D diffusion-relaxation correlation spectroscopic imaging (DR-CSI), in terms of their potential to quantify tissue microstructure, including the myelin water fraction (MWF). We observe a distinct spectral peak that we attribute to myelin water in multi-component T1 relaxometry, T1-T2 correlation, T1-D correlation, and T2-D correlation imaging. Due to lower achievable echo times compared to diffusometry, MWF maps from relaxometry have higher quality. While 1D multi-component T1 data allows much faster myelin mapping, 2D approaches could offer unique insights into tissue microstructure and especially myelin diffusion. UR - https://doi.org/10.21203/rs.3.rs-3069146/v1 Y1 - 2023 UR - https://doi.org/10.21203/rs.3.rs-3069146/v1 UR - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:573-46448 SN - 2693-5015 N1 - Die veröffentlichte Version dieses Preprints ist ebenfalls in diesem Repositorium verzeichnet, s. https://opus4.kobv.de/opus4-haw/frontdoor/index/index/docId/4031 PB - Research Square CY - Durham ER - TY - CHAP A1 - Endt, Sebastian A1 - Pirkl, Carolin A1 - Verdun, Claudio A1 - Menze, Bjoern H. A1 - Menzel, Marion Irene ED - Romero, Eduardo ED - Costa, Eduardo Tavares ED - Brieva, Jorge ED - Rittner, Leticia ED - Linguraru, Marius George ED - Lepore, Natasha T1 - Unmixing tissue compartments via deep learning T1-T2-relaxation correlation imaging T2 - 17th International Symposium on Medical Information Processing and Analysis UR - https://doi.org/10.1117/12.2604737 Y1 - 2021 UR - https://doi.org/10.1117/12.2604737 SN - 978-1-5106-5053-4 SN - 978-1-5106-5052-7 PB - SPIE CY - Bellingham ER -