TY - INPR A1 - Aubreville, Marc A1 - Stathonikos, Nikolas A1 - Donovan, Taryn A1 - Klopfleisch, Robert A1 - Ganz, Jonathan A1 - Ammeling, Jonas A1 - Wilm, Frauke A1 - Veta, Mitko A1 - Jabari, Samir A1 - Eckstein, Markus A1 - Annuscheit, Jonas A1 - Krumnow, Christian A1 - Bozaba, Engin A1 - Cayir, Sercan A1 - Gu, Hongyan A1 - Chen, Xiang A1 - Jahanifar, Mostafa A1 - Shephard, Adam A1 - Kondo, Satoshi A1 - Kasai, Satoshi A1 - Kotte, Sujatha A1 - Saipradeep, Vangala A1 - Lafarge, Maxime W. A1 - Koelzer, Viktor H. A1 - Wang, Ziyue A1 - Zhang, Yongbing A1 - Yang, Sen A1 - Wang, Xiyue A1 - Breininger, Katharina A1 - Bertram, Christof T1 - Domain generalization across tumor types, laboratories, and species – Insights from the 2022 edition of the Mitosis Domain Generalization Challenge N2 - Recognition of mitotic figures in histologic tumor specimens is highly relevant to patient outcome assessment. This task is challenging for algorithms and human experts alike, with deterioration of algorithmic performance under shifts in image representations. Considerable covariate shifts occur when assessment is performed on different tumor types, images are acquired using different digitization devices, or specimens are produced in different laboratories. This observation motivated the inception of the 2022 challenge on MItosis Domain Generalization (MIDOG 2022). The challenge provided annotated histologic tumor images from six different domains and evaluated the algorithmic approaches for mitotic figure detection provided by nine challenge participants on ten independent domains. Ground truth for mitotic figure detection was established in two ways: a three-expert consensus and an independent, immunohistochemistry-assisted set of labels. This work represents an overview of the challenge tasks, the algorithmic strategies employed by the participants, and potential factors contributing to their success. With an F1 score of 0.764 for the top-performing team, we summarize that domain generalization across various tumor domains is possible with today's deep learning-based recognition pipelines. When assessed against the immunohistochemistry-assisted reference standard, all methods resulted in reduced recall scores, but with only minor changes in the order of participants in the ranking. UR - https://doi.org/10.48550/arXiv.2309.15589 Y1 - 2023 UR - https://doi.org/10.48550/arXiv.2309.15589 UR - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:573-41514 PB - arXiv CY - Ithaca ER - TY - CHAP A1 - Eisenmann, Matthias A1 - Reinke, Annika A1 - Weru, Vivienn A1 - Tizabi, Minu Dietlinde A1 - Isensee, Fabian A1 - Adler, Tim J. A1 - Ali, Sharib A1 - Andrearczyk, Vincent A1 - Aubreville, Marc A1 - Baid, Ujjwal A1 - Bakas, Spyridon A1 - Balu, Niranjan A1 - Bano, Sophia A1 - Bernal, Jorge A1 - Bodenstedt, Sebastian A1 - Casella, Alessandro A1 - Cheplygina, Veronika A1 - Daum, Marie A1 - De Bruijne, Marleen A1 - Depeursinge, Adrien A1 - Dorent, Reuben A1 - Egger, Jan A1 - Ellis, David G. A1 - Engelhardt, Sandy A1 - Ganz, Melanie A1 - Ghatwary, Noha M. A1 - Girard, Gabriel A1 - Godau, Patrick A1 - Gupta, Anubha A1 - Hansen, Lasse A1 - Harada, Kanako A1 - Heinrich, Mattias A1 - Heller, Nicholas A1 - Hering, Alessa A1 - Huaulmé, Arnoud A1 - Jannin, Pierre A1 - Kavur, A. Emre A1 - Kodym, Oldrich A1 - Kozubek, Michal A1 - Li, Jianning A1 - Li, Hongwei A1 - Ma, Jun A1 - Martín-Isla, Carlos A1 - Menze, Bjoern H. A1 - Noble, Alison A1 - Oreiller, Valentin A1 - Padoy, Nicolas A1 - Pati, Sarthak A1 - Payette, Kelly A1 - Rädsch, Tim A1 - Rafael-Patiño, Jonathan A1 - Bawa, Vivek Singh A1 - Speidel, Stefanie A1 - Sudre, Carole H. A1 - Van Wijnen, Kimberlin M. H. A1 - Wagner, M. A1 - Wei, D. A1 - Yamlahi, Amine A1 - Yap, Moi Hoon A1 - Yuan, C. A1 - Zenk, Maximilian A1 - Zia, A. A1 - Zimmerer, David A1 - Aydogan, Dogu Baran A1 - Bhattarai, B. A1 - Bloch, Louise A1 - Brüngel, Raphael A1 - Cho, J. A1 - Choi, C. A1 - Dou, Q. A1 - Ezhov, Ivan A1 - Friedrich, Christoph M. A1 - Fuller, C. A1 - Gaire, Rebati Raman A1 - Galdran, Adrian A1 - García-Faura, Álvaro A1 - Grammatikopoulou, Maria A1 - Hong, S. A1 - Jahanifar, Mostafa A1 - Jang, I. A1 - Kadkhodamohammadi, Abdolrahim A1 - Kang, I. A1 - Kofler, Florian A1 - Kondo, Satoshi A1 - Kuijf, Hugo Jaco A1 - Li, M. A1 - Luu, M. A1 - Martinčič, Tomaz A1 - Morais, P. A1 - Naser, M. A. A1 - Oliveira, B. A1 - Owen, D. A1 - Pang, S. A1 - Park, Jinah A1 - Park, S. A1 - Płotka, S. A1 - Puybareau, Élodie A1 - Rajpoot, Nasir M. A1 - Ryu, K. A1 - Saeed, N. A1 - Shephard, Adam A1 - Shi, P. A1 - Štepec, Dejan A1 - Subedi, Ronast A1 - Tochon, Guillaume A1 - Torres, Helena R. A1 - Urien, Hélène A1 - Vilaça, João L. A1 - Wahid, Kareem A. A1 - Wang, H. A1 - Wang, J. A1 - Wang, L. A1 - Wang, Xiyue A1 - Wiestler, Benedikt A1 - Wodzinski, Marek A1 - Xia, F. A1 - Xie, J. A1 - Xiong, Z. A1 - Yang, Sen A1 - Yang, Y. A1 - Zhao, Z. A1 - Maier-Hein, Klaus H. A1 - Jäger, Paul F. A1 - Kopp-Schneider, Annette A1 - Maier-Hein, Lena T1 - Why is the Winner the Best? T2 - Proceedings: 2023 IEEE/CVF Conference on Computer Vision and Pattern Recognition UR - https://doi.org/10.1109/CVPR52729.2023.01911 KW - Medical and biological vision KW - cell microscopy Y1 - 2023 UR - https://doi.org/10.1109/CVPR52729.2023.01911 SN - 979-8-3503-0129-8 SN - 2575-7075 SP - 19955 EP - 19967 PB - IEEE CY - Los Alamitos ER -