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  <doc>
    <id>1182</id>
    <completedYear>2019</completedYear>
    <publishedYear>2019</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>389</pageFirst>
    <pageLast>395</pageLast>
    <pageNumber/>
    <edition/>
    <issue>6</issue>
    <volume>39</volume>
    <articleNumber/>
    <type>article</type>
    <publisherName>Pacini</publisherName>
    <publisherPlace>Pisa</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2022-02-10</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Probe-based confocal laser endomicroscopy in detecting malignant lesions of vocal folds</title>
    <abstract language="eng">Probe-based confocal laser endomicroscopy (CLE) is an innovative technique for real-time, non-invasive analysis of the surface epithelium.&#13;
While being successfully used for diagnosis by experts, this method has not yet been established in clinical routine, partly due to the lack of standards and criteria for classifying various lesions. Our aim was to determine the diagnostic value and inter-rater reliability of CLE in detecting malignant lesions of the vocal cords. 58 video sequences were extracted from the probe-based CLE (GastroFlex probe with a Cellvizio® laser system) examinations of 3 patients with squamous cell carcinomas and 4 patients with benign alterations of the vocal folds. Two ENT surgeons, who were blinded to the histological result, were asked to identify the sequences representing a carcinoma. We showed an accuracy, sensitivity, specificity, PPV and NPV of 91.38-96.55%, 100%, 87.8-95.2%, 77.27-89.47% and 100%, respectively, with an inter-rater reliability of k = 0.89 (“almost perfect agreement”). Probe-based CLE is a promising method for diagnosis and assessment of vocal fold lesions in vivo. Our results suggest that, with adequate training, the diagnostic value of this technique can be improved and potentially provide important information during oncological surgery.</abstract>
    <parentTitle language="eng">ACTA Otorhinolaryngologica Italica</parentTitle>
    <identifier type="issn">1827-675X</identifier>
    <identifier type="urn">urn:nbn:de:bvb:573-11824</identifier>
    <enrichment key="THI_articleversion">published</enrichment>
    <enrichment key="THI_relatedIdentifier">https://doi.org/10.14639/0392-100X-2121</enrichment>
    <enrichment key="THI_review">peer-review</enrichment>
    <enrichment key="THI_openaccess">ja</enrichment>
    <licence>Creative Commons BY-NC-ND 4.0</licence>
    <author>
      <first_name>Miguel</first_name>
      <last_name>Goncalves</last_name>
    </author>
    <author>
      <first_name>Marc</first_name>
      <last_name>Aubreville</last_name>
    </author>
    <author>
      <first_name>Sarina K.</first_name>
      <last_name>Müller</last_name>
    </author>
    <author>
      <first_name>Matti</first_name>
      <last_name>Sievert</last_name>
    </author>
    <author>
      <first_name>Andreas</first_name>
      <last_name>Maier</last_name>
    </author>
    <author>
      <first_name>Heinrich</first_name>
      <last_name>Iro</last_name>
    </author>
    <author>
      <first_name>Christopher</first_name>
      <last_name>Bohr</last_name>
    </author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Confocal laser endomicroscopy</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Laryngeal cancer</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Non-invasive histological imaging</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Vocal folds</value>
    </subject>
    <collection role="open_access" number="">open_access</collection>
    <thesisPublisher>Technische Hochschule Ingolstadt</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-haw/files/1182/117-Article_Text-667-2-10-20191220.pdf</file>
  </doc>
  <doc>
    <id>1175</id>
    <completedYear>2021</completedYear>
    <publishedYear>2021</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>764</pageFirst>
    <pageLast>769</pageLast>
    <pageNumber/>
    <edition/>
    <issue>4</issue>
    <volume>48</volume>
    <articleNumber/>
    <type>article</type>
    <publisherName>Elsevier Science</publisherName>
    <publisherPlace>Amsterdam</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2022-02-10</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Feasibility of intraoperative assessment of safe surgical margins during laryngectomy with confocal laser endomicroscopy</title>
    <parentTitle language="eng">Auris Nasus Larynx</parentTitle>
    <subTitle language="eng">a pilot study</subTitle>
    <identifier type="issn">1879-1476</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="THI_relatedIdentifier">https://doi.org/10.1016/j.anl.2021.01.005</enrichment>
    <enrichment key="THI_articleversion">published</enrichment>
    <enrichment key="THI_openaccess">nein</enrichment>
    <enrichment key="THI_review">peer-review</enrichment>
    <author>
      <first_name>Matti</first_name>
      <last_name>Sievert</last_name>
    </author>
    <author>
      <first_name>Nicolai</first_name>
      <last_name>Oetter</last_name>
    </author>
    <author>
      <first_name>Marc</first_name>
      <last_name>Aubreville</last_name>
    </author>
    <author>
      <first_name>Florian</first_name>
      <last_name>Stelzle</last_name>
    </author>
    <author>
      <first_name>Andreas</first_name>
      <last_name>Maier</last_name>
    </author>
    <author>
      <first_name>Markus</first_name>
      <last_name>Eckstein</last_name>
    </author>
    <author>
      <first_name>Konstantinos</first_name>
      <last_name>Mantsopoulos</last_name>
    </author>
    <author>
      <first_name>Antoniu-Oreste</first_name>
      <last_name>Gostian</last_name>
    </author>
    <author>
      <first_name>Sarina K.</first_name>
      <last_name>Müller</last_name>
    </author>
    <author>
      <first_name>Michael</first_name>
      <last_name>Koch</last_name>
    </author>
    <author>
      <first_name>Abbas</first_name>
      <last_name>Agaimy</last_name>
    </author>
    <author>
      <first_name>Heinrich</first_name>
      <last_name>Iro</last_name>
    </author>
    <author>
      <first_name>Miguel</first_name>
      <last_name>Goncalves</last_name>
    </author>
  </doc>
  <doc>
    <id>4152</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>6</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <articleNumber/>
    <type>preprint</type>
    <publisherName>arXiv</publisherName>
    <publisherPlace>Ithaca</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Few Shot Learning for the Classification of Confocal Laser Endomicroscopy Images of Head and Neck Tumors</title>
    <abstract language="eng">The surgical removal of head and neck tumors requires safe margins, which are usually confirmed intraoperatively by means of frozen sections. This method is, in itself, an oversampling procedure, which has a relatively low sensitivity compared to the definitive tissue analysis on paraffin-embedded sections. Confocal laser endomicroscopy (CLE) is an in-vivo imaging technique that has shown its potential in the live optical biopsy of tissue. An automated analysis of this notoriously difficult to interpret modality would help surgeons. However, the images of CLE show a wide variability of patterns, caused both by individual factors but also, and most strongly, by the anatomical structures of the imaged tissue, making it a challenging pattern recognition task. In this work, we evaluate four popular few shot learning (FSL) methods towards their capability of generalizing to unseen anatomical domains in CLE images. We evaluate this on images of sinunasal tumors (SNT) from five patients and on images of the vocal folds (VF) from 11 patients using a cross-validation scheme. The best respective approach reached a median accuracy of 79.6% on the rather homogeneous VF dataset, but only of 61.6% for the highly diverse SNT dataset. Our results indicate that FSL on CLE images is viable, but strongly affected by the number of patients, as well as the diversity of anatomical patterns.</abstract>
    <identifier type="urn">urn:nbn:de:bvb:573-41522</identifier>
    <enrichment key="THI_relatedIdentifier">https://doi.org/10.48550/arXiv.2311.07216</enrichment>
    <enrichment key="THI_openaccess">ja</enrichment>
    <enrichment key="THI_review">nein</enrichment>
    <licence>Creative Commons BY-SA 4.0</licence>
    <author>
      <first_name>Marc</first_name>
      <last_name>Aubreville</last_name>
    </author>
    <author>
      <first_name>Zhaoya</first_name>
      <last_name>Pan</last_name>
    </author>
    <author>
      <first_name>Matti</first_name>
      <last_name>Sievert</last_name>
    </author>
    <author>
      <first_name>Jonas</first_name>
      <last_name>Ammeling</last_name>
    </author>
    <author>
      <first_name>Jonathan</first_name>
      <last_name>Ganz</last_name>
    </author>
    <author>
      <first_name>Nicolai</first_name>
      <last_name>Oetter</last_name>
    </author>
    <author>
      <first_name>Florian</first_name>
      <last_name>Stelzle</last_name>
    </author>
    <author>
      <first_name>Ann-Kathrin</first_name>
      <last_name>Frenken</last_name>
    </author>
    <author>
      <first_name>Katharina</first_name>
      <last_name>Breininger</last_name>
    </author>
    <author>
      <first_name>Miguel</first_name>
      <last_name>Goncalves</last_name>
    </author>
    <collection role="open_access" number="">open_access</collection>
    <collection role="institutes" number="19309">Fakultät Informatik</collection>
    <collection role="institutes" number="19379">AImotion Bavaria</collection>
    <thesisPublisher>Technische Hochschule Ingolstadt</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-haw/files/4152/2311.07216.pdf</file>
  </doc>
  <doc>
    <id>2917</id>
    <completedYear/>
    <publishedYear>2022</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>26</pageFirst>
    <pageLast>33</pageLast>
    <pageNumber/>
    <edition/>
    <issue>1</issue>
    <volume>42</volume>
    <articleNumber/>
    <type>article</type>
    <publisherName>Pacini</publisherName>
    <publisherPlace>Pisa</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>2022-10-21</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Systematic interpretation of confocal laser endomicroscopy: larynx and pharynx confocal imaging score</title>
    <abstract language="eng">Objective. Development and validation of a confocal laser endomicroscopy (CLE) classification score for the larynx and pharynx.&#13;
&#13;
Methods. Thirteen patients (154 video sequences, 9240 images) with laryngeal or pharyngeal SCC were included in this prospective study between October 2020 and February 2021. Each CLE sequence was correlated with the gold standard of histopathological examination. Based on a dataset of 94 video sequences (5640 images), a scoring system was developed. In the remaining 60 sequences (3600 images), the score was validated by four CLE experts and four head and neck surgeons who were not familiar with CLE.&#13;
&#13;
Results. Tissue homogeneity, cell size, borders and clusters, capillary loops and the nucleus/ cytoplasm ratio were defined as the scoring criteria. Using this score, the CLE experts obtained an accuracy, sensitivity, and specificity of 90.8%, 95.1%, and 86.4%, respectively, and the CLE non-experts of 86.2%, 86.4%, and 86.1%. Interobserver agreement Fleiss’ kappa was 0.8 and 0.6, respectively.&#13;
&#13;
Conclusions. CLE can be reliably evaluated based on defined and reproducible imaging features, which demonstrate a high diagnostic value. CLE can be easily integrated into the intraoperative setting and generate real-time, in-vivo microscopic images to demarcate malignant changes.</abstract>
    <parentTitle language="eng">Acta otorhinolaryngologica italica</parentTitle>
    <identifier type="issn">1827-675X</identifier>
    <identifier type="urn">urn:nbn:de:bvb:573-29175</identifier>
    <enrichment key="THI_relatedIdentifier">https://doi.org/10.14639/0392-100X-N1643</enrichment>
    <enrichment key="THI_articleversion">published</enrichment>
    <enrichment key="THI_review">peer-review</enrichment>
    <enrichment key="THI_openaccess">ja</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <licence>Creative Commons BY-NC-ND 4.0</licence>
    <author>
      <first_name>Matti</first_name>
      <last_name>Sievert</last_name>
    </author>
    <author>
      <first_name>Konstantinos</first_name>
      <last_name>Mantsopoulos</last_name>
    </author>
    <author>
      <first_name>Sarina K.</first_name>
      <last_name>Müller</last_name>
    </author>
    <author>
      <first_name>Markus</first_name>
      <last_name>Eckstein</last_name>
    </author>
    <author>
      <first_name>Robin</first_name>
      <last_name>Rupp</last_name>
    </author>
    <author>
      <first_name>Marc</first_name>
      <last_name>Aubreville</last_name>
    </author>
    <author>
      <first_name>Florian</first_name>
      <last_name>Stelzle</last_name>
    </author>
    <author>
      <first_name>Nicolai</first_name>
      <last_name>Oetter</last_name>
    </author>
    <author>
      <first_name>Andreas</first_name>
      <last_name>Maier</last_name>
    </author>
    <author>
      <first_name>Heinrich</first_name>
      <last_name>Iro</last_name>
    </author>
    <author>
      <first_name>Miguel</first_name>
      <last_name>Goncalves</last_name>
    </author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>confocal laser endomicroscopy</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>head and neck cancer</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>classification system</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>non-invasive histological imaging</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>larynx</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>pharynx</value>
    </subject>
    <collection role="open_access" number="">open_access</collection>
    <collection role="institutes" number="19309">Fakultät Informatik</collection>
    <collection role="institutes" number="19379">AImotion Bavaria</collection>
    <thesisPublisher>Technische Hochschule Ingolstadt</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-haw/files/2917/1643-ArticleText-17164-2-10-20220307.pdf</file>
  </doc>
  <doc>
    <id>4835</id>
    <completedYear/>
    <publishedYear>2024</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>4217</pageFirst>
    <pageLast>4224</pageLast>
    <pageNumber/>
    <edition/>
    <issue>10</issue>
    <volume>134</volume>
    <articleNumber/>
    <type>article</type>
    <publisherName>Wiley</publisherName>
    <publisherPlace>Malden</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>2024-07-03</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Feasibility of Optical Biopsy During Endoscopic Sinus Surgery With Confocal Laser Endomicroscopy: A Pilot Study</title>
    <parentTitle language="eng">The Laryngoscope</parentTitle>
    <identifier type="issn">1531-4995</identifier>
    <enrichment key="opus_doi_flag">true</enrichment>
    <enrichment key="opus_import_data">{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,19]],"date-time":"2024-05-19T01:06:40Z","timestamp":1716080800454},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T00:00:00Z","timestamp":1715990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GO 3182\/2\u20101"]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"abstract":"&lt;jats:sec&gt;&lt;jats:title&gt;Objective&lt;\/jats:title&gt;&lt;jats:p&gt;Confocal laser endomicroscopy (CLE) is an optical imaging technique that allows in vivo, real\u2010time, microscope\u2010like assessment of superficial lesions. Although there is substantial data on CLE use in the upper GI tract, there is limited information regarding its application in the nasal cavity and paranasal sinuses. This study aims to assess the feasibility and diagnostic metrics of CLE in the nasal cavity and paranasal sinuses regarding differentiation between healthy\/benign and malignant tissue. These structures show, however, a wider variety of frequent and concomitant benign and malignant pathologies, which could pose an increased challenge for optical biopsy by CLE.&lt;\/jats:p&gt;&lt;\/jats:sec&gt;&lt;jats:sec&gt;&lt;jats:title&gt;Methods&lt;\/jats:title&gt;&lt;jats:p&gt;We performed CLE on a case series of six patients with various findings in the nose (three chronic rhinosinusitis, adenocarcinoma, meningoenzephalozele, esthesionneuroblastoma). Forty\u2010two sequences (3792 images) from various structures in the nasal cavity and\/or paranasal sinuses were acquired. Biopsies were taken at corresponding locations and analyzed in hematoxylin and eosin staining as a standard of reference. Three independent examiners blinded to the histopathology assessed the sequences.&lt;\/jats:p&gt;&lt;\/jats:sec&gt;&lt;jats:sec&gt;&lt;jats:title&gt;Results&lt;\/jats:title&gt;&lt;jats:p&gt;Healthy and inflamed mucosa could be distinguished from malignant lesions with an accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of 84.1%, 85.4%, 83.1%, 72.5%, and 92.1%, respectively, with a substantial agreement between raters (Fleiss &lt;jats:italic&gt;\u03ba&lt;\/jats:italic&gt;\u2009=\u20090.62).&lt;\/jats:p&gt;&lt;\/jats:sec&gt;&lt;jats:sec&gt;&lt;jats:title&gt;Conclusion&lt;\/jats:title&gt;&lt;jats:p&gt;This technique shows, despite its limitations, potential as an adjunctive imaging technique during sinus surgery; however, the creation of a scoring system based on reproducible and defined characteristics in a larger more diverse population should be the focus of further research to improve its diagnostic value and clinical utility.&lt;\/jats:p&gt;&lt;\/jats:sec&gt;&lt;jats:sec&gt;&lt;jats:title&gt;Level of Evidence&lt;\/jats:title&gt;&lt;jats:p&gt;NA &lt;jats:italic&gt;Laryngoscope&lt;\/jats:italic&gt;, 2024&lt;\/jats:p&gt;&lt;\/jats:sec&gt;","DOI":"10.1002\/lary.31503","type":"journal-article","created":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T13:26:50Z","timestamp":1716038810000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility of Optical Biopsy During Endoscopic Sinus Surgery With Confocal Laser Endomicroscopy: A Pilot Study"],"prefix":"10.1002","author":[{"ORCID":"http:\/\/orcid.org\/0009-0001-5050-7710","authenticated-orcid":false,"given":"Ann\u2010Kathrin","family":"Frenken","sequence":"first","affiliation":[{"name":"RWTH\u2010Aachen University  Aachen Germany"}]},{"ORCID":"http:\/\/orcid.org\/0000-0003-0741-4049","authenticated-orcid":false,"given":"Matti","family":"Sievert","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg, University Hospital  Erlangen Germany"}]},{"given":"Bharat","family":"Panuganti","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology The University of Alabama at Birmingham, School of Medicine  Birmingham Alabama U.S.A."}]},{"given":"Marc","family":"Aubreville","sequence":"additional","affiliation":[{"name":"Technische Hochschule Ingolstadt  Ingolstadt Germany"}]},{"given":"Till","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery University Hospital W\u00fcrzburg  W\u00fcrzburg Germany"}]},{"given":"Agmal","family":"Scherzad","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery University Hospital W\u00fcrzburg  W\u00fcrzburg Germany"}]},{"ORCID":"http:\/\/orcid.org\/0000-0001-7417-3009","authenticated-orcid":false,"given":"Thomas","family":"Gehrke","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery University Hospital W\u00fcrzburg  W\u00fcrzburg Germany"}]},{"given":"Matthias","family":"Scheich","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery University Hospital W\u00fcrzburg  W\u00fcrzburg Germany"}]},{"given":"Stephan","family":"Hackenberg","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery University Hospital W\u00fcrzburg  W\u00fcrzburg Germany"}]},{"given":"Miguel","family":"Goncalves","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery University Hospital W\u00fcrzburg  W\u00fcrzburg 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    <title language="eng">Diagnosis of malignancy in oropharyngeal confocal laser endomicroscopy using GPT 4.0 with vision</title>
    <parentTitle language="eng">European Archives of Oto-Rhino-Laryngology</parentTitle>
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      <first_name>Marc</first_name>
      <last_name>Aubreville</last_name>
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    <author>
      <first_name>Sarina Katrin</first_name>
      <last_name>Mueller</last_name>
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    <author>
      <first_name>Markus</first_name>
      <last_name>Eckstein</last_name>
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    <author>
      <first_name>Katharina</first_name>
      <last_name>Breininger</last_name>
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      <first_name>Heinrich</first_name>
      <last_name>Iro</last_name>
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      <first_name>Miguel</first_name>
      <last_name>Goncalves</last_name>
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    <completedYear/>
    <publishedYear>2022</publishedYear>
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    <language>eng</language>
    <pageFirst>4147</pageFirst>
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    <issue>8</issue>
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    <title language="eng">Validity of tissue homogeneity in confocal laser endomicroscopy on the diagnosis of laryngeal and hypopharyngeal squamous cell carcinoma</title>
    <abstract language="eng">Purpose&#13;
Confocal laser endomicroscopy (CLE) allows imaging of the laryngeal mucosa in a thousand-fold magnification. This study analyzes differences in tissue homogeneity between healthy mucosa and squamous cell carcinoma (SCC) via CLE.&#13;
&#13;
Materials and methods&#13;
We included five SCC patients with planned total laryngectomy in this study between October 2020 and February 2021. We captured CLE scans of the tumor and healthy mucosa. Analysis of image homogeneity to diagnose SCC was performed by measuring the signal intensity in four regions of interest (ROI) in each frame in a total of 60 sequences. Each sequence was assigned to the corresponding histological pattern, derived from hematoxylin and eosin staining. In addition, we recorded the subjective evaluation of seven investigators regarding tissue homogeneity.&#13;
&#13;
Results&#13;
Out of 3600 images, 1620 (45%) correlated with benign mucosa and 1980 (55%) with SCC. ROIs of benign mucosa and SCC had a mean and standard deviation (SD) of signal intensity of, respectively, 232.1 ± 3.34 and 467.3 ± 9.72 (P &lt; 0.001). The mean SD between the four different ROIs was 39.1 ± 1.03 for benign and 101.5 ± 2.6 for SCC frames (P &lt; 0.001). In addition, homogeneity yielded a sensitivity and specificity of 81.8% and 86.2%, respectively, regarding the investigator-dependent analysis.&#13;
&#13;
Conclusions&#13;
SCC shows a significant tissue inhomogeneity in comparison to the healthy epithelium. The results support this feature’s importance in identifying malignant mucosa areas during CLE examination. However, the examiner-dependent evaluation emphasizes that homogeneity is a sub-criterion that must be considered in a broad context.</abstract>
    <parentTitle language="eng">European Archives of Oto-Rhino-Laryngology and Head &amp; Neck</parentTitle>
    <identifier type="issn">1434-4726</identifier>
    <identifier type="issn">0937-4477</identifier>
    <identifier type="urn">urn:nbn:de:bvb:573-23180</identifier>
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    <licence>Creative Commons BY 4.0</licence>
    <author>
      <first_name>Matti</first_name>
      <last_name>Sievert</last_name>
    </author>
    <author>
      <first_name>Marc</first_name>
      <last_name>Aubreville</last_name>
    </author>
    <author>
      <first_name>Antoniu-Oreste</first_name>
      <last_name>Gostian</last_name>
    </author>
    <author>
      <first_name>Konstantinos</first_name>
      <last_name>Mantsopoulos</last_name>
    </author>
    <author>
      <first_name>Michael</first_name>
      <last_name>Koch</last_name>
    </author>
    <author>
      <first_name>Sarina K.</first_name>
      <last_name>Müller</last_name>
    </author>
    <author>
      <first_name>Markus</first_name>
      <last_name>Eckstein</last_name>
    </author>
    <author>
      <first_name>Robin</first_name>
      <last_name>Rupp</last_name>
    </author>
    <author>
      <first_name>Florian</first_name>
      <last_name>Stelzle</last_name>
    </author>
    <author>
      <first_name>Nicolai</first_name>
      <last_name>Oetter</last_name>
    </author>
    <author>
      <first_name>Andreas</first_name>
      <last_name>Maier</last_name>
    </author>
    <author>
      <first_name>Heinrich</first_name>
      <last_name>Iro</last_name>
    </author>
    <author>
      <first_name>Miguel</first_name>
      <last_name>Goncalves</last_name>
    </author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>confocal laser endomicroscopy</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>head and neck cancer</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>classification system</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>non-invasive histological imaging</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>larynx</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>pharynx</value>
    </subject>
    <collection role="open_access" number="">open_access</collection>
    <collection role="institutes" number="19309">Fakultät Informatik</collection>
    <collection role="institutes" number="19379">AImotion Bavaria</collection>
    <thesisPublisher>Technische Hochschule Ingolstadt</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-haw/files/2318/Sievert2022_ValidityOfTissueHomogeneity.pdf</file>
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    <id>2088</id>
    <completedYear/>
    <publishedYear>2021</publishedYear>
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    <language>eng</language>
    <pageFirst>26</pageFirst>
    <pageLast>32</pageLast>
    <pageNumber/>
    <edition/>
    <issue>88, S4</issue>
    <volume>2022</volume>
    <articleNumber/>
    <type>article</type>
    <publisherName>Elsevier</publisherName>
    <publisherPlace>Amsterdam</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>2022-03-18</completedDate>
    <publishedDate>--</publishedDate>
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    <title language="eng">Validation of a classification and scoring system for the diagnosis of laryngeal and pharyngeal squamous cell carcinomas by confocal laser endomicroscopy</title>
    <abstract language="eng">Introduction&#13;
Confocal laser endomicroscopy is an optical imaging technique that allows in vivo, real-time, microscope-like images of the upper aerodigestive tract’s mucosa. The assessment of morphological tissue characteristics for the correct differentiation between healthy and malignant suspected mucosa requires strict evaluation criteria.&#13;
&#13;
Objective&#13;
This study aims to validate an eight-point score for the correct assessment of malignancy.&#13;
&#13;
Methods&#13;
We performed confocal laser endomicroscopy between March and October 2020 in 13 patients. 197 sequences (11.820 images) originated from the marginal area of pharyngeal and laryngeal carcinomas. Specimens were taken at corresponding locations and analyzed in H&amp;E staining as a standard of reference. A total of six examiners evaluated the sequences based on a scoring system; they were blinded to the histopathological examination. The primary endpoints are sensitivity, specificity, and accuracy. Secondary endpoints are interrater reliability and receiver operator characteristics.&#13;
&#13;
Results&#13;
Healthy mucosa showed epithelium with uniform size and shape with distinct cytoplasmic membranes and regular vessel architecture. Confocal laser endomicroscopy of malignant cells demonstrated a disorganized arrangement of variable cellular morphology. We calculated an accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of 83.2%, 81.3%, 85.5%, 86.7%, and 79.7%, respectively, with a κ-value of 0.64, and an area under the curve of 0.86.&#13;
&#13;
Conclusion&#13;
The results confirm that this scoring system is applicable in the laryngeal and pharyngeal mucosa to classify benign and malignant tissue. A scoring system based on defined and reproducible characteristics can help translate this experimental method to broad clinical practice in head and neck diagnosis.</abstract>
    <parentTitle language="eng">Brazilian Journal of Otorhinolaryngology</parentTitle>
    <identifier type="issn">1808-8694</identifier>
    <identifier type="urn">urn:nbn:de:bvb:573-20887</identifier>
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    <licence>Creative Commons BY 4.0</licence>
    <author>
      <first_name>Matti</first_name>
      <last_name>Sievert</last_name>
    </author>
    <author>
      <first_name>Konstantinos</first_name>
      <last_name>Mantsopoulos</last_name>
    </author>
    <author>
      <first_name>Sarina K.</first_name>
      <last_name>Müller</last_name>
    </author>
    <author>
      <first_name>Robin</first_name>
      <last_name>Rupp</last_name>
    </author>
    <author>
      <first_name>Markus</first_name>
      <last_name>Eckstein</last_name>
    </author>
    <author>
      <first_name>Florian</first_name>
      <last_name>Stelzle</last_name>
    </author>
    <author>
      <first_name>Nicolai</first_name>
      <last_name>Oetter</last_name>
    </author>
    <author>
      <first_name>Andreas</first_name>
      <last_name>Maier</last_name>
    </author>
    <author>
      <first_name>Marc</first_name>
      <last_name>Aubreville</last_name>
    </author>
    <author>
      <first_name>Heinrich</first_name>
      <last_name>Iro</last_name>
    </author>
    <author>
      <first_name>Miguel</first_name>
      <last_name>Goncalves</last_name>
    </author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>confocal laser endomicroscopy</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>squamous cell carcinoma</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>head and neck cancer</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>diagnosis</value>
    </subject>
    <collection role="open_access" number="">open_access</collection>
    <collection role="institutes" number="19309">Fakultät Informatik</collection>
    <collection role="institutes" number="19379">AImotion Bavaria</collection>
    <thesisPublisher>Technische Hochschule Ingolstadt</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-haw/files/2088/1-s2.0-S1808869421001245-main.pdf</file>
  </doc>
  <doc>
    <id>2319</id>
    <completedYear/>
    <publishedYear>2021</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>2029</pageFirst>
    <pageLast>2037</pageLast>
    <pageNumber/>
    <edition/>
    <issue>4</issue>
    <volume>279</volume>
    <articleNumber/>
    <type>article</type>
    <publisherName>Springer Nature</publisherName>
    <publisherPlace>Cham</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>2022-05-04</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Impact of intraepithelial capillary loops and atypical vessels in confocal laser endomicroscopy for the diagnosis of laryngeal and hypopharyngeal squamous cell carcinoma</title>
    <abstract language="eng">Purpose&#13;
Confocal laser endomicroscopy (CLE) allows surface imaging of the laryngeal and pharyngeal mucosa in vivo at a thousand-fold magnification. This study aims to compare irregular blood vessels and intraepithelial capillary loops in healthy mucosa and squamous cell carcinoma (SCC) via CLE.&#13;
&#13;
Materials and methods&#13;
We included ten patients with confirmed SCC and planned total laryngectomy in this study between March 2020 and February 2021. CLE images of these patients were collected and compared with the corresponding histology in hematoxylin and eosin staining. We analyzed the characteristic endomicroscopic patterns of blood vessels and intraepithelial capillary loops for the diagnosis of SCC.&#13;
&#13;
Results&#13;
In a total of 54 sequences, we identified 243 blood vessels which were analyzed regarding structure, diameter, and Fluorescein leakage, confirming that irregular, corkscrew-like vessels (24.4% vs. 1.3%; P &lt; .001), dilated intraepithelial capillary loops (90.8% vs. 28.7%; P &lt; .001), and increased capillary leakage (40.7% vs. 2.5%; P &lt; .001), are significantly more frequently detected in SCC compared to the healthy epithelium. We defined a vessel diameter of 30 μm in capillary loops as a cut-off value, obtaining a sensitivity, specificity, PPV, and NPV and accuracy of 90.6%, 71.3%, 57.4%, 94.7%, and 77.1%, respectively, for the detection of malignancy based solely on capillary architecture.&#13;
&#13;
Conclusion&#13;
Capillaries within malignant lesions are fundamentally different from those in healthy mucosa regions. The capillary architecture is a significant feature aiding the identification of malignant mucosa areas during in-vivo, real-time CLE examination.</abstract>
    <parentTitle language="eng">European Archives of Oto-Rhino-Laryngology and Head &amp; Neck</parentTitle>
    <identifier type="issn">1434-4726</identifier>
    <identifier type="issn">0937-4477</identifier>
    <identifier type="urn">urn:nbn:de:bvb:573-23196</identifier>
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    <licence>Creative Commons BY 4.0</licence>
    <author>
      <first_name>Matti</first_name>
      <last_name>Sievert</last_name>
    </author>
    <author>
      <first_name>Markus</first_name>
      <last_name>Eckstein</last_name>
    </author>
    <author>
      <first_name>Konstantinos</first_name>
      <last_name>Mantsopoulos</last_name>
    </author>
    <author>
      <first_name>Sarina K.</first_name>
      <last_name>Müller</last_name>
    </author>
    <author>
      <first_name>Florian</first_name>
      <last_name>Stelzle</last_name>
    </author>
    <author>
      <first_name>Marc</first_name>
      <last_name>Aubreville</last_name>
    </author>
    <author>
      <first_name>Nicolai</first_name>
      <last_name>Oetter</last_name>
    </author>
    <author>
      <first_name>Andreas</first_name>
      <last_name>Maier</last_name>
    </author>
    <author>
      <first_name>Heinrich</first_name>
      <last_name>Iro</last_name>
    </author>
    <author>
      <first_name>Miguel</first_name>
      <last_name>Goncalves</last_name>
    </author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>confocal laser endomicroscopy</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>head and neck squamous cell carcinoma</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>capillary loops</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>malignant vascularization</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>head and neck malignancies</value>
    </subject>
    <collection role="open_access" number="">open_access</collection>
    <collection role="institutes" number="19309">Fakultät Informatik</collection>
    <collection role="institutes" number="19379">AImotion Bavaria</collection>
    <thesisPublisher>Technische Hochschule Ingolstadt</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-haw/files/2319/Article_ImpactOfIntraepithelial.pdf</file>
  </doc>
  <doc>
    <id>3040</id>
    <completedYear/>
    <publishedYear>2022</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>6</pageNumber>
    <edition/>
    <issue>2</issue>
    <volume>44</volume>
    <articleNumber>103779</articleNumber>
    <type>article</type>
    <publisherName>Elsevier</publisherName>
    <publisherPlace>Amsterdam</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>2022-12-30</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Defining a baseline identification of artifacts in confocal laser endomicroscopy in head and neck cancer imaging</title>
    <parentTitle language="eng">American Journal of Otolaryngology</parentTitle>
    <identifier type="issn">1532-818X</identifier>
    <identifier type="issn">0196-0709</identifier>
    <enrichment key="THI_relatedIdentifier">https://doi.org/10.1016/j.amjoto.2022.103779</enrichment>
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    <enrichment key="THI_openaccess">nein</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <author>
      <first_name>Zhaoya</first_name>
      <last_name>Pan</last_name>
    </author>
    <author>
      <first_name>Katharina</first_name>
      <last_name>Breininger</last_name>
    </author>
    <author>
      <first_name>Marc</first_name>
      <last_name>Aubreville</last_name>
    </author>
    <author>
      <first_name>Florian</first_name>
      <last_name>Stelzle</last_name>
    </author>
    <author>
      <first_name>Nicolai</first_name>
      <last_name>Oetter</last_name>
    </author>
    <author>
      <first_name>Andreas</first_name>
      <last_name>Maier</last_name>
    </author>
    <author>
      <first_name>Konstantinos</first_name>
      <last_name>Mantsopoulos</last_name>
    </author>
    <author>
      <first_name>Heinrich</first_name>
      <last_name>Iro</last_name>
    </author>
    <author>
      <first_name>Miguel</first_name>
      <last_name>Goncalves</last_name>
    </author>
    <author>
      <first_name>Matti</first_name>
      <last_name>Sievert</last_name>
    </author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Confocal laser endomicroscopy</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Head and neck cancer</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Classification system</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Non-invasive histological imaging</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Larynx</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Pharynx</value>
    </subject>
    <collection role="institutes" number="19309">Fakultät Informatik</collection>
    <collection role="institutes" number="19379">AImotion Bavaria</collection>
  </doc>
  <doc>
    <id>3871</id>
    <completedYear/>
    <publishedYear>2021</publishedYear>
    <thesisYearAccepted/>
    <language>deu</language>
    <pageFirst>875</pageFirst>
    <pageLast>881</pageLast>
    <pageNumber/>
    <edition/>
    <issue>11</issue>
    <volume>100</volume>
    <articleNumber/>
    <type>article</type>
    <publisherName>Thieme</publisherName>
    <publisherPlace>Stuttgart</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="deu">Konfokale Laser-Endomikroskopie des Kopf-Hals-Plattenepithelkarzinoms: eine systematische Übersicht</title>
    <parentTitle language="deu">Laryngo-Rhino-Otologie</parentTitle>
    <additionalTitle language="eng">Confocal laser endomicroscopy of head and neck squamous cell carcinoma: a systematic review</additionalTitle>
    <identifier type="issn">0935-8943</identifier>
    <enrichment key="opus_doi_flag">true</enrichment>
    <enrichment key="opus_import_data">{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T18:07:58Z","timestamp":1680199678986},"reference-count":38,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngorhinootologie"],"published-print":{"date-parts":[[2021,11]]},"abstract":"&lt;jats:title&gt;Zusammenfassung&lt;\/jats:title&gt;&lt;jats:p&gt;\n          Hintergrund\u2002Die konfokale Laser-Endomikroskopie (CLE) bietet mit einer bis zu 1000-fachen Vergr\u00f6\u00dferungsleistung die M\u00f6glichkeit, Interzellularr\u00e4ume in vivo zu erkennen. Die CLE hat sich in verschiedensten Fachbereichen bereits etabliert. Dieser Artikel gibt einen \u00dcberblick \u00fcber die aktuelle Studienlage der CLE in der Diagnostik des Plattenepithelkarzinoms des Kopf-Hals-Bereichs.&lt;\/jats:p&gt;&lt;jats:p&gt;\n          Material und Methoden\u2002Systematische Literaturrecherche in folgenden Online-Datenbanken: PubMed, MEDLINE, Thompson Reuters Web of Science, SPIE nach den Suchbegriffen: confocal laser endomicroscopy, CLE, endomicroscopy, head and neck, larynx. 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\u00dcbersicht"],"prefix":"10.1055","volume":"100","author":[{"ORCID":"http:\/\/orcid.org\/0000-0003-0741-4049","authenticated-orcid":false,"given":"Matti","family":"Sievert","sequence":"additional","affiliation":[{"name":"Hals-Nasen-Ohrenklinik, Kopf- und Hals-Chirurgie, Universit\u00e4tsklinikum Erlangen, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Deutschland"}]},{"given":"Marc","family":"Auberville","sequence":"additional","affiliation":[{"name":"Bildverstehen und medizinische Anwendung der k\u00fcnstlichen Intelligenz, Fakult\u00e4t Informatik, Technische Hochschule Ingolstadt, Deutschland"}]},{"given":"Nicolai","family":"Oetter","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Mund-Kiefer-Gesichtschirurgie, Universit\u00e4tsklinikum Erlangen, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Deutschland"}]},{"given":"Florian","family":"Stelzle","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Mund-Kiefer-Gesichtschirurgie, Universit\u00e4tsklinikum Erlangen, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Deutschland"}]},{"given":"Andreas","family":"Maier","sequence":"additional","affiliation":[{"name":"Pattern Recognition Lab, Computer Science, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Deutschland"}]},{"given":"Konstantinos","family":"Mantsopoulos","sequence":"additional","affiliation":[{"name":"Hals-Nasen-Ohrenklinik, Kopf- und Hals-Chirurgie, Universit\u00e4tsklinikum Erlangen, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Deutschland"}]},{"given":"Heinrich","family":"Iro","sequence":"additional","affiliation":[{"name":"Hals-Nasen-Ohrenklinik, Kopf- und Hals-Chirurgie, Universit\u00e4tsklinikum Erlangen, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Deutschland"}]},{"given":"Miguel","family":"Goncalves","sequence":"additional","affiliation":[{"name":"Hals-Nasen-Ohrenklinik, Kopf- und Hals-Chirurgie, 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Betz","year":"2016","journal-title":"HNO"},{"key":"ref4","first-page":"47","article-title":"Intraoperative onlinebildgesteuerte Biopsien auf Basis eines Deep-Learning-Algorithmus zur automatischen Detektion von Kopf-Hals-Karzinomen mittels Real-Time Nah-Infrarot ICG-Fluoreszenz-Endoskopie","volume":"98","author":"A Dittberner","year":"2019","journal-title":"Laryngo-Rhino-Otologie"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1053\/j.gastro.2010.06.029","article-title":"Confocal laser endomicroscopy: Technical advances and clinical application","volume":"139","author":"H Neumann","year":"2010","journal-title":"Gastroenterology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1097\/LBR.0000000000000412","article-title":"Probe-based confocal laser endomicroscopy in metastatic pulmonary calcification","volume":"25","author":"I Vasilev","year":"2018","journal-title":"J Bronchology Interv 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    <author>
      <first_name>Matti</first_name>
      <last_name>Sievert</last_name>
    </author>
    <author>
      <first_name>Marc</first_name>
      <last_name>Aubreville</last_name>
    </author>
    <author>
      <first_name>Nicolai</first_name>
      <last_name>Oetter</last_name>
    </author>
    <author>
      <first_name>Florian</first_name>
      <last_name>Stelzle</last_name>
    </author>
    <author>
      <first_name>Andreas</first_name>
      <last_name>Maier</last_name>
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    <author>
      <first_name>Konstantinos</first_name>
      <last_name>Mantsopoulos</last_name>
    </author>
    <author>
      <first_name>Heinrich</first_name>
      <last_name>Iro</last_name>
    </author>
    <author>
      <first_name>Miguel</first_name>
      <last_name>Goncalves</last_name>
    </author>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>konfokale Laser-Endomikroskopie</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>CLE</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Kopf-Hals-Malignom</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Larynxkarzinom</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Bildanalyse</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>confocal laser endomicroscopy</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>head and neck malignancy</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>laryngeal carcinoma</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>image analysis</value>
    </subject>
    <collection role="institutes" number="19309">Fakultät Informatik</collection>
  </doc>
  <doc>
    <id>1091</id>
    <completedYear>2021</completedYear>
    <publishedYear>2021</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>4433</pageFirst>
    <pageLast>4439</pageLast>
    <pageNumber/>
    <edition/>
    <issue>11</issue>
    <volume>278</volume>
    <articleNumber/>
    <type>article</type>
    <publisherName>Springer Nature</publisherName>
    <publisherPlace>Cham</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>2021-12-22</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Intraoperative free margins assessment of oropharyngeal squamous cell carcinoma with confocal laser endomicroscopy: a pilot study</title>
    <abstract language="eng">Purpose&#13;
This pilot study aimed to assess the feasibility of intraoperative assessment of safe margins with confocal laser endomicroscopy (CLE) during oropharyngeal squamous cell carcinoma (OPSCC) surgery.&#13;
&#13;
Methods&#13;
We included five consecutive patients confirmed OPSCC and planned tumor resection in September and October 2020. Healthy appearing mucosa in the marginal zone, and the tumor margin, were examined with CLE and biopsy during tumor resection. A total of 12,809 CLE frames were correlated with the gold standard of hematoxylin and eosin staining. Three head and neck surgeons and one pathologist were asked to identify carcinoma in a sample of 169 representative images, blinded to the histological results.&#13;
&#13;
Results&#13;
Healthy mucosa showed epithelium with uniform size and shape with distinct cytoplasmic membranes and regular vessel architecture. CLE optical biopsy of OPSCC demonstrated a disorganized arrangement of variable cellular morphology. We calculated an accuracy, sensitivity, specificity, PPV, and NPV of 86%, 90%, 79%, 88%, and 82%, respectively, with inter-rater reliability and κ-value of 0.60.&#13;
&#13;
Conclusion&#13;
CLE can be easily integrated into the intraoperative setting, generate real-time, in-vivo microscopic images of the oropharynx for evaluation and demarcation of cancer. It can eventually contribute to a less radical approach by enabling a more precise evaluation of the cancer margin.</abstract>
    <parentTitle language="eng">European Archives of Oto-Rhino-Laryngology and Head &amp; Neck</parentTitle>
    <identifier type="issn">1434-4726</identifier>
    <identifier type="issn">0937-4477</identifier>
    <identifier type="urn">urn:nbn:de:bvb:573-10914</identifier>
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    <licence>Creative Commons BY 4.0</licence>
    <author>
      <first_name>Matti</first_name>
      <last_name>Sievert</last_name>
    </author>
    <author>
      <first_name>Florian</first_name>
      <last_name>Stelzle</last_name>
    </author>
    <author>
      <first_name>Marc</first_name>
      <last_name>Aubreville</last_name>
    </author>
    <author>
      <first_name>Sarina K.</first_name>
      <last_name>Müller</last_name>
    </author>
    <author>
      <first_name>Markus</first_name>
      <last_name>Eckstein</last_name>
    </author>
    <author>
      <first_name>Nicolai</first_name>
      <last_name>Oetter</last_name>
    </author>
    <author>
      <first_name>Andreas</first_name>
      <last_name>Maier</last_name>
    </author>
    <author>
      <first_name>Konstantinos</first_name>
      <last_name>Mantsopoulos</last_name>
    </author>
    <author>
      <first_name>Heinrich</first_name>
      <last_name>Iro</last_name>
    </author>
    <author>
      <first_name>Miguel</first_name>
      <last_name>Goncalves</last_name>
    </author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Confocal laser endomicroscopy</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Oropharyngeal squamous cell carcinoma</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Safe surgical margins</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Head and neck malignancies</value>
    </subject>
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    <collection role="institutes" number="19309">Fakultät Informatik</collection>
    <collection role="institutes" number="19379">AImotion Bavaria</collection>
    <thesisPublisher>Technische Hochschule Ingolstadt</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-haw/files/1091/Sievert2021_Article_IntraoperativeFreeMargins.pdf</file>
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  <doc>
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    <completedYear/>
    <publishedYear>2024</publishedYear>
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    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>11</pageNumber>
    <edition/>
    <issue>5</issue>
    <volume>28</volume>
    <articleNumber>266</articleNumber>
    <type>article</type>
    <publisherName>Springer</publisherName>
    <publisherPlace>Berlin</publisherPlace>
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    <title language="eng">Oral mucosa - an examination map for confocal laser endomicroscopy within the oral cavity: an experimental clinical study</title>
    <abstract language="eng">Objectives&#13;
Confocal laser endomicroscopy (CLE) is an optical method that enables microscopic visualization of oral mucosa. Previous studies have shown that it is possible to differentiate between physiological and malignant oral mucosa. However, differences in mucosal architecture were not taken into account. The objective was to map the different oral mucosal morphologies and to establish a “CLE map” of physiological mucosa as baseline for further application of this powerful technology. &#13;
                &#13;
Materials and methods&#13;
The CLE database consisted of 27 patients. The following spots were examined: (1) upper lip (intraoral) (2) alveolar ridge (3) lateral tongue (4) floor of the mouth (5) hard palate (6) intercalary line. All sequences were examined by two CLE experts for morphological differences and video quality. &#13;
&#13;
Results&#13;
Analysis revealed clear differences in image quality and possibility of depicting tissue morphologies between the various localizations of oral mucosa: imaging of the alveolar ridge and hard palate showed visually most discriminative tissue morphology. Labial mucosa was also visualized well using CLE. Here, typical morphological features such as uniform cells with regular intercellular gaps and vessels could be clearly depicted. Image generation and evaluation was particularly difficult in the area of the buccal mucosa, the lateral tongue and the floor of the mouth. &#13;
&#13;
Conclusion&#13;
A physiological “CLE map” for the entire oral cavity could be created for the first time. &#13;
&#13;
Clinical relevance&#13;
This will make it possible to take into account the existing physiological morphological features when differentiating between normal mucosa and oral squamous cell carcinoma in future work.</abstract>
    <parentTitle language="eng">Clinical Oral Investigations</parentTitle>
    <identifier type="issn">1436-3771</identifier>
    <identifier type="urn">urn:nbn:de:bvb:573-56000</identifier>
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    <licence>Creative Commons BY 4.0</licence>
    <author>
      <first_name>Nicolai</first_name>
      <last_name>Oetter</last_name>
    </author>
    <author>
      <first_name>Jonas</first_name>
      <last_name>Pröll</last_name>
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    <author>
      <first_name>Matti</first_name>
      <last_name>Sievert</last_name>
    </author>
    <author>
      <first_name>Miguel</first_name>
      <last_name>Goncalves</last_name>
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      <first_name>Maximilian</first_name>
      <last_name>Rohde</last_name>
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      <first_name>Christopher-Philipp</first_name>
      <last_name>Nobis</last_name>
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    <author>
      <first_name>Christian</first_name>
      <last_name>Knipfer</last_name>
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    <author>
      <first_name>Marc</first_name>
      <last_name>Aubreville</last_name>
    </author>
    <author>
      <first_name>Zhaoya</first_name>
      <last_name>Pan</last_name>
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    <author>
      <first_name>Katharina</first_name>
      <last_name>Breininger</last_name>
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      <first_name>Andreas</first_name>
      <last_name>Maier</last_name>
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    <author>
      <first_name>Marco</first_name>
      <last_name>Kesting</last_name>
    </author>
    <author>
      <first_name>Florian</first_name>
      <last_name>Stelzle</last_name>
    </author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Confocal laser endomicroscopy</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Oral cavity</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Oral carcinoma</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Optical methods</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Oral cavity squamous cell carcinoma</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Head and neck cancer</value>
    </subject>
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    <collection role="institutes" number="19309">Fakultät Informatik</collection>
    <collection role="institutes" number="19379">AImotion Bavaria</collection>
    <collection role="Import" number="deepgreen">DeepGreen</collection>
    <thesisPublisher>Technische Hochschule Ingolstadt</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-haw/files/5600/s00784-024-05664-9.pdf</file>
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