<?xml version="1.0" encoding="utf-8"?>
<export-example>
  <doc>
    <id>2728</id>
    <completedYear/>
    <publishedYear>2018</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>24</pageNumber>
    <edition/>
    <issue>3</issue>
    <volume>13</volume>
    <articleNumber>e0195126</articleNumber>
    <type>article</type>
    <publisherName>PLOS</publisherName>
    <publisherPlace>San Francisco</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2022-08-22</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">A Boolean network of the crosstalk between IGF and Wnt signaling in aging satellite cells</title>
    <abstract language="eng">Aging is a complex biological process, which determines the life span of an organism. Insulin-like growth factor (IGF) and Wnt signaling pathways govern the process of aging. Both pathways share common downstream targets that allow competitive crosstalk between these branches. Of note, a shift from IGF to Wnt signaling has been observed during aging of satellite cells. Biological regulatory networks necessary to recreate aging have not yet been discovered. Here, we established a mathematical in silico model that robustly recapitulates the crosstalk between IGF and Wnt signaling. Strikingly, it predicts critical nodes following a shift from IGF to Wnt signaling. These findings indicate that this shift might cause age-related diseases.</abstract>
    <parentTitle language="eng">PLOS ONE</parentTitle>
    <identifier type="issn">1932-6203</identifier>
    <identifier type="urn">urn:nbn:de:bvb:573-27280</identifier>
    <enrichment key="THI_relatedIdentifier">https://doi.org/10.1371/journal.pone.0195126</enrichment>
    <enrichment key="THI_articleversion">published</enrichment>
    <enrichment key="THI_review">peer-review</enrichment>
    <enrichment key="THI_openaccess">ja</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <licence>Creative Commons BY 4.0</licence>
    <author>
      <first_name>Lea</first_name>
      <last_name>Kubis</last_name>
    </author>
    <author>
      <first_name>Julian D.</first_name>
      <last_name>Schwab</last_name>
    </author>
    <author>
      <first_name>Silke D.</first_name>
      <last_name>Werle</last_name>
    </author>
    <author>
      <first_name>Ludwig</first_name>
      <last_name>Lausser</last_name>
    </author>
    <author>
      <first_name>Stefan</first_name>
      <last_name>Tümpel</last_name>
    </author>
    <author>
      <first_name>Astrid S.</first_name>
      <last_name>Pfister</last_name>
    </author>
    <author>
      <first_name>Michael</first_name>
      <last_name>Kühl</last_name>
    </author>
    <author>
      <first_name>Hans A.</first_name>
      <last_name>Kestler</last_name>
    </author>
    <collection role="open_access" number="">open_access</collection>
    <collection role="persons" number="49455">Lausser, Ludwig</collection>
    <thesisPublisher>Technische Hochschule Ingolstadt</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-haw/files/2728/file-1.pdf</file>
  </doc>
</export-example>
