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  <doc>
    <id>1459</id>
    <completedYear/>
    <publishedYear>2020</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>26</pageFirst>
    <pageLast>31</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <articleNumber/>
    <type>conferenceobject</type>
    <publisherName>Springer Vieweg</publisherName>
    <publisherPlace>Wiesbaden</publisherPlace>
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    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2022-02-24</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Is crowd-algorithm collaboration an advanced alternative to crowd-sourcing on cytology slides?</title>
    <parentTitle language="deu">Bildverarbeitung für die Medizin 2020, Algorithmen – Systeme – Anwendungen. Proceedings des Workshops vom 15. bis 17. März 2020 in Berlin</parentTitle>
    <identifier type="isbn">978-3-658-29266-9</identifier>
    <identifier type="isbn">978-3-658-29267-6</identifier>
    <note>Access to this content is enabled by Nationallizenz Ebooks Medicine</note>
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    <author>
      <first_name>Christian</first_name>
      <last_name>Marzahl</last_name>
    </author>
    <editor>
      <first_name>Thomas</first_name>
      <last_name>Tolxdorff</last_name>
    </editor>
    <author>
      <first_name>Marc</first_name>
      <last_name>Aubreville</last_name>
    </author>
    <editor>
      <first_name>Thomas Martin</first_name>
      <last_name>Deserno</last_name>
    </editor>
    <author>
      <first_name>Christof</first_name>
      <last_name>Bertram</last_name>
    </author>
    <editor>
      <first_name>Heinz</first_name>
      <last_name>Handels</last_name>
    </editor>
    <author>
      <first_name>Stefan</first_name>
      <last_name>Gerlach</last_name>
    </author>
    <editor>
      <first_name>Andreas</first_name>
      <last_name>Maier</last_name>
    </editor>
    <author>
      <first_name>Jennifer</first_name>
      <last_name>Maier</last_name>
    </author>
    <editor>
      <first_name>Klaus H.</first_name>
      <last_name>Maier-Hein</last_name>
    </editor>
    <author>
      <first_name>Jörn</first_name>
      <last_name>Voigt</last_name>
    </author>
    <editor>
      <first_name>Christoph</first_name>
      <last_name>Palm</last_name>
    </editor>
    <author>
      <first_name>Jenny</first_name>
      <last_name>Hill</last_name>
    </author>
    <author>
      <first_name>Robert</first_name>
      <last_name>Klopfleisch</last_name>
    </author>
    <author>
      <first_name>Andreas</first_name>
      <last_name>Maier</last_name>
    </author>
  </doc>
  <doc>
    <id>1178</id>
    <completedYear>2020</completedYear>
    <publishedYear>2020</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>10</pageNumber>
    <edition/>
    <issue/>
    <volume>10</volume>
    <articleNumber>9795</articleNumber>
    <type>article</type>
    <publisherName>Springer Nature</publisherName>
    <publisherPlace>London</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2022-02-10</completedDate>
    <publishedDate>--</publishedDate>
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    <title language="eng">Deep Learning-based quantification of pulmonary hemosiderophages in cytology slides</title>
    <abstract language="eng">Exercise-induced pulmonary hemorrhage (EIPH) is a common condition in sport horses with negative impact on performance. Cytology of bronchoalveolar lavage fluid by use of a scoring system is considered the most sensitive diagnostic method. Macrophages are classified depending on the degree of cytoplasmic hemosiderin content. The current gold standard is manual grading, which is however monotonous and time-consuming. We evaluated state-of-the-art deep learning-based methods for single cell macrophage classification and compared them against the performance of nine cytology experts and evaluated inter- and intra-observer variability. Additionally, we evaluated object detection methods on a novel data set of 17 completely annotated cytology whole slide images (WSI) containing 78,047 hemosiderophages. Our deep learning-based approach reached a concordance of 0.85, partially exceeding human expert concordance (0.68 to 0.86, mean of 0.73, SD of 0.04). Intra-observer variability was high (0.68 to 0.88) and inter-observer concordance was moderate (Fleiss’ kappa = 0.67). Our object detection approach has a mean average precision of 0.66 over the five classes from the whole slide gigapixel image and a computation time of below two minutes. To mitigate the high inter- and intra-rater variability, we propose our automated object detection pipeline, enabling accurate, reproducible and quick EIPH scoring in WSI.</abstract>
    <parentTitle language="eng">Scientific Reports</parentTitle>
    <identifier type="issn">2045-2322</identifier>
    <identifier type="urn">urn:nbn:de:bvb:573-11783</identifier>
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    <enrichment key="THI_relatedIdentifier">https://doi.org/10.1038/s41598-020-65958-2</enrichment>
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    <enrichment key="THI_articleversion">published</enrichment>
    <licence>Creative Commons BY 4.0</licence>
    <author>
      <first_name>Christian</first_name>
      <last_name>Marzahl</last_name>
    </author>
    <author>
      <first_name>Marc</first_name>
      <last_name>Aubreville</last_name>
    </author>
    <author>
      <first_name>Christof</first_name>
      <last_name>Bertram</last_name>
    </author>
    <author>
      <first_name>Jason</first_name>
      <last_name>Stayt</last_name>
    </author>
    <author>
      <first_name>Anne-Katherine</first_name>
      <last_name>Jasensky</last_name>
    </author>
    <author>
      <first_name>Florian</first_name>
      <last_name>Bartenschlager</last_name>
    </author>
    <author>
      <first_name>Marco</first_name>
      <last_name>Fragoso-Garcia</last_name>
    </author>
    <author>
      <first_name>Ann K.</first_name>
      <last_name>Barton</last_name>
    </author>
    <author>
      <first_name>Svenja</first_name>
      <last_name>Elsemann</last_name>
    </author>
    <author>
      <first_name>Samir</first_name>
      <last_name>Jabari</last_name>
    </author>
    <author>
      <first_name>Jens</first_name>
      <last_name>Krauth</last_name>
    </author>
    <author>
      <first_name>Prathmesh</first_name>
      <last_name>Madhu</last_name>
    </author>
    <author>
      <first_name>Jörn</first_name>
      <last_name>Voigt</last_name>
    </author>
    <author>
      <first_name>Jenny</first_name>
      <last_name>Hill</last_name>
    </author>
    <author>
      <first_name>Robert</first_name>
      <last_name>Klopfleisch</last_name>
    </author>
    <author>
      <first_name>Andreas</first_name>
      <last_name>Maier</last_name>
    </author>
    <collection role="open_access" number="">open_access</collection>
    <thesisPublisher>Technische Hochschule Ingolstadt</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-haw/files/1178/s41598-020-65958-2.pdf</file>
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  <doc>
    <id>1917</id>
    <completedYear/>
    <publishedYear>2020</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>24</pageFirst>
    <pageLast>32</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <articleNumber/>
    <type>conferenceobject</type>
    <publisherName>Springer</publisherName>
    <publisherPlace>Cham</publisherPlace>
    <creatingCorporation/>
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    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2022-03-11</completedDate>
    <publishedDate>--</publishedDate>
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    <title language="eng">Are Fast Labeling Methods Reliable? A Case Study of Computer-Aided Expert Annotations on Microscopy Slides</title>
    <parentTitle language="eng">Medical Image Computing and Computer Assisted Intervention – MICCAI 2020</parentTitle>
    <identifier type="issn">1611-3349</identifier>
    <identifier type="isbn">978-3-030-59710-8</identifier>
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    <enrichment key="THI_conferenceName">Medical Image Computing and Computer Assisted Intervention – MICCAI 2020, online, 04.-08.10.2020</enrichment>
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    <enrichment key="THI_furtherversion">https://opus4.kobv.de/opus4-haw/frontdoor/index/index/docId/1257</enrichment>
    <author>
      <first_name>Christian</first_name>
      <last_name>Marzahl</last_name>
    </author>
    <author>
      <first_name>Christof</first_name>
      <last_name>Bertram</last_name>
    </author>
    <author>
      <first_name>Marc</first_name>
      <last_name>Aubreville</last_name>
    </author>
    <author>
      <first_name>Anne</first_name>
      <last_name>Petrick</last_name>
    </author>
    <author>
      <first_name>Kristina</first_name>
      <last_name>Weiler</last_name>
    </author>
    <author>
      <first_name>Agnes C.</first_name>
      <last_name>Gläsel</last_name>
    </author>
    <author>
      <first_name>Marco</first_name>
      <last_name>Fragoso-Garcia</last_name>
    </author>
    <author>
      <first_name>Sophie</first_name>
      <last_name>Merz</last_name>
    </author>
    <author>
      <first_name>Florian</first_name>
      <last_name>Bartenschlager</last_name>
    </author>
    <author>
      <first_name>Judith</first_name>
      <last_name>Hoppe</last_name>
    </author>
    <author>
      <first_name>Alina</first_name>
      <last_name>Langenhagen</last_name>
    </author>
    <author>
      <first_name>Anne-Katherine</first_name>
      <last_name>Jasensky</last_name>
    </author>
    <author>
      <first_name>Jörn</first_name>
      <last_name>Voigt</last_name>
    </author>
    <author>
      <first_name>Robert</first_name>
      <last_name>Klopfleisch</last_name>
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    <author>
      <first_name>Andreas</first_name>
      <last_name>Maier</last_name>
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    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Pathology</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Microscopy</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Computer-aided labelling</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Expert-algorithm collaboration</value>
    </subject>
  </doc>
  <doc>
    <id>1257</id>
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    <publishedYear>2020</publishedYear>
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    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>10</pageNumber>
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    <type>preprint</type>
    <publisherName>arXiv</publisherName>
    <publisherPlace>Ithaca</publisherPlace>
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    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2022-02-15</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Are Fast Labeling Methods Reliable? A Case Study of Computer-Aided Expert Annotations on Microscopy Slides</title>
    <enrichment key="THI_relatedIdentifier">https://doi.org/10.48550/arXiv.2004.05838</enrichment>
    <enrichment key="THI_review">nein</enrichment>
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    <enrichment key="THI_furtherversion">https://opus4.kobv.de/opus4-haw/frontdoor/index/index/docId/1917</enrichment>
    <author>
      <first_name>Christian</first_name>
      <last_name>Marzahl</last_name>
    </author>
    <author>
      <first_name>Christof</first_name>
      <last_name>Bertram</last_name>
    </author>
    <author>
      <first_name>Marc</first_name>
      <last_name>Aubreville</last_name>
    </author>
    <author>
      <first_name>Anne</first_name>
      <last_name>Petrick</last_name>
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    <author>
      <first_name>Kristina</first_name>
      <last_name>Weiler</last_name>
    </author>
    <author>
      <first_name>Agnes C.</first_name>
      <last_name>Gläsel</last_name>
    </author>
    <author>
      <first_name>Marco</first_name>
      <last_name>Fragoso-Garcia</last_name>
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    <author>
      <first_name>Sophie</first_name>
      <last_name>Merz</last_name>
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    <author>
      <first_name>Florian</first_name>
      <last_name>Bartenschlager</last_name>
    </author>
    <author>
      <first_name>Judith</first_name>
      <last_name>Hoppe</last_name>
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    <author>
      <first_name>Alina</first_name>
      <last_name>Langenhagen</last_name>
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    <author>
      <first_name>Anne-Katherine</first_name>
      <last_name>Jasensky</last_name>
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    <author>
      <first_name>Jörn</first_name>
      <last_name>Voigt</last_name>
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    <author>
      <first_name>Robert</first_name>
      <last_name>Klopfleisch</last_name>
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    <author>
      <first_name>Andreas</first_name>
      <last_name>Maier</last_name>
    </author>
  </doc>
</export-example>
