@article{FreierBockletHeltenetal.2023, author = {Freier, Carolin and Bocklet, Tobias and Helten, Anne-Kathrin and Hoffmann, Franziska and Hunger, Marianne and Kov{\´a}cs, L{\´a}szl{\´o} and Richter, Florian and Riedhammer, Korbinian and Schmohl, Tobias and Simon, Claudia}, title = {Wie kann videogest{\"u}tztes Lernen die Erwartungen Studierender und Dozierender erf{\"u}llen?}, volume = {15}, journal = {Soziale Passagen}, number = {2}, publisher = {Springer}, address = {Wiesbaden}, issn = {1867-0199}, doi = {https://doi.org/10.1007/s12592-023-00478-0}, pages = {631 -- 635}, year = {2023}, abstract = {ZusammenfassungIm BMBF-Verbundprojekt HAnS entwickeln und implementieren neun Hochschulen sowie drei hochschul{\"u}bergreifende Einrichtungen ein intelligentes Hochschul-Assistenz-System als Open-Source-L{\"o}sung. Videobasierte Lehrmaterialien werden verschriftlicht und durch eine Indexierung Stichwortsuchen erm{\"o}glicht; geplant ist, {\"u}ber einen KI-Tutor automatisiert {\"U}bungsaufgaben zu generieren. Studierende sollen so in ihrem Selbststudium digital unterst{\"u}tzt werden. Die technische Entwicklung wird interdisziplin{\"a}r - auch sozialwissenschaftlich und p{\"a}dagogisch - begleitet und in einem iterativen Vorgehen evidenzbasiert entsprechend Design-Based-Research angepasst. Wissen und Wertesystem der Anwender*innen, Didaktik, Ethik, Akzeptanz und Datenschutz werden dabei im Entwicklungsprozess einbezogen.}, language = {de} } @article{GlahnHaghoferDonovanetal.2024, author = {Glahn, Imaine and Haghofer, Andreas and Donovan, Taryn A. and Degasperi, Brigitte and Bartel, Alexander and Kreilmeier-Berger, Theresa and Hyndman, Philip S. and Janout, Hannah and Assenmacher, Charles-Antoine and Bartenschlager, Florian and Bolfa, Pompei and Dark, Michael J. and Klang, Andrea and Klopfleisch, Robert and Merz, Sophie and Richter, Barbara and Schulman, F. Yvonne and Ganz, Jonathan and Scharinger, Josef and Aubreville, Marc and Winkler, Stephan M. and Bertram, Christof A.}, title = {Automated Nuclear Morphometry: A Deep Learning Approach for Prognostication in Canine Pulmonary Carcinoma to Enhance Reproducibility}, volume = {11}, pages = {278}, journal = {Veterinary Sciences}, number = {6}, publisher = {MDPI}, address = {Basel}, issn = {2306-7381}, doi = {https://doi.org/10.3390/vetsci11060278}, year = {2024}, abstract = {The integration of deep learning-based tools into diagnostic workflows is increasingly prevalent due to their efficiency and reproducibility in various settings. We investigated the utility of automated nuclear morphometry for assessing nuclear pleomorphism (NP), a criterion of malignancy in the current grading system in canine pulmonary carcinoma (cPC), and its prognostic implications. We developed a deep learning-based algorithm for evaluating NP (variation in size, i.e., anisokaryosis and/or shape) using a segmentation model. Its performance was evaluated on 46 cPC cases with comprehensive follow-up data regarding its accuracy in nuclear segmentation and its prognostic ability. Its assessment of NP was compared to manual morphometry and established prognostic tests (pathologists' NP estimates (n = 11), mitotic count, histological grading, and TNM-stage). The standard deviation (SD) of the nuclear area, indicative of anisokaryosis, exhibited good discriminatory ability for tumor-specific survival, with an area under the curve (AUC) of 0.80 and a hazard ratio (HR) of 3.38. The algorithm achieved values comparable to manual morphometry. In contrast, the pathologists' estimates of anisokaryosis resulted in HR values ranging from 0.86 to 34.8, with slight inter-observer reproducibility (k = 0.204). Other conventional tests had no significant prognostic value in our study cohort. Fully automated morphometry promises a time-efficient and reproducible assessment of NP with a high prognostic value. Further refinement of the algorithm, particularly to address undersegmentation, and application to a larger study population are required.}, language = {en} }