@thesis{Fuchs2022, author = {Fuchs, Barbara}, title = {Vom Assistenten zum Freund}, subtitle = {Design eines sozialen pers{\"o}nlichen Roboters}, publisher = {Technische Hochschule Ingolstadt}, address = {Ingolstadt}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:573-34577}, pages = {vi, 79}, school = {Technische Hochschule Ingolstadt}, year = {2022}, abstract = {Mit der kontinuierlichen Verbreitung von sozialen Robotern ist es nur eine Frage der Zeit, bis sich die Hausrobotik auch im Privatbereich durchsetzt. Bis heute sind jedoch nur wenige soziale Roboter kommerziell erfolgreich, was oft weniger am Fortschritt der Technologie liegt, sondern an mangelnden Produktkonzepten. In dieser Arbeit wird deswegen ein neues Konzept f{\"u}r soziale Roboter vorgeschlagen: ein Pers{\"o}nlicher Roboter (kurz: PR), der als pers{\"o}nlicher, individueller Gegenstand einer einzigen Person dient. Es wird untersucht, welche F{\"a}higkeiten ein PR ben{\"o}tigt, um von seinem Nutzer als soziales Wesen wahrgenommen zu werden und welche Rolle er im Leben seines Besitzers spielen kann. Zudem wird fokussiert, wie ein Roboter seinen Besitzer in dessen sozialen Aufgaben unterst{\"u}tzen kann. {\"U}ber eine neuartige, explorative Online-Umfrage wird das Konzept und seine Features anschließend evaluiert.}, language = {de} } @inproceedings{HimmelsCzupalaFahmuelleretal.2022, author = {Himmels, Chantal and Czupala, Andr{\´e} Reinhold and Fahm{\"u}ller, Tobias and Fuchs, Barbara and Hauf, Lea and Heidler, Linda and Riener, Andreas}, title = {The Influence of Gaming Experience and Optic Flow on Simulator Sickness: Insights from a Driving Simulator Study}, booktitle = {Adjunct Proceedings: 14th International ACM Conference on Automotive User Interfaces and Interactive Vehicular Applications}, publisher = {ACM}, address = {New York}, isbn = {978-1-4503-9428-4}, doi = {https://doi.org/10.1145/3544999.3552532}, pages = {149 -- 152}, year = {2022}, language = {en} } @unpublished{HaghoferParlakBarteletal.2023, author = {Haghofer, Andreas and Parlak, Eda and Bartel, Alexander and Donovan, Taryn and Assenmacher, Charles-Antoine and Bolfa, Pompei and Dark, Michael and Fuchs-Baumgartinger, Andrea and Klang, Andrea and J{\"a}ger, Kathrin and Klopfleisch, Robert and Merz, Sophie and Richter, Barbara and Schulman, F. Yvonne and Ganz, Jonathan and Scharinger, Josef and Aubreville, Marc and Winkler, Stephan M. and Kiupel, Matti and Bertram, Christof}, title = {Nuclear Morphometry using a Deep Learning-based Algorithm has Prognostic Relevance for Canine Cutaneous Mast Cell Tumors}, publisher = {arXiv}, address = {Ithaca}, doi = {https://doi.org/10.48550/arXiv.2309.15031}, year = {2023}, abstract = {Variation in nuclear size and shape is an important criterion of malignancy for many tumor types; however, categorical estimates by pathologists have poor reproducibility. Measurements of nuclear characteristics (morphometry) can improve reproducibility, but manual methods are time consuming. In this study, we evaluated fully automated morphometry using a deep learning-based algorithm in 96 canine cutaneous mast cell tumors with information on patient survival. Algorithmic morphometry was compared with karyomegaly estimates by 11 pathologists, manual nuclear morphometry of 12 cells by 9 pathologists, and the mitotic count as a benchmark. The prognostic value of automated morphometry was high with an area under the ROC curve regarding the tumor-specific survival of 0.943 (95\% CI: 0.889 - 0.996) for the standard deviation (SD) of nuclear area, which was higher than manual morphometry of all pathologists combined (0.868, 95\% CI: 0.737 - 0.991) and the mitotic count (0.885, 95\% CI: 0.765 - 1.00). At the proposed thresholds, the hazard ratio for algorithmic morphometry (SD of nuclear area ≥9.0μm2) was 18.3 (95\% CI: 5.0 - 67.1), for manual morphometry (SD of nuclear area ≥10.9μm2) 9.0 (95\% CI: 6.0 - 13.4), for karyomegaly estimates 7.6 (95\% CI: 5.7 - 10.1), and for the mitotic count 30.5 (95\% CI: 7.8 - 118.0). Inter-rater reproducibility for karyomegaly estimates was fair (κ = 0.226) with highly variable sensitivity/specificity values for the individual pathologists. Reproducibility for manual morphometry (SD of nuclear area) was good (ICC = 0.654). This study supports the use of algorithmic morphometry as a prognostic test to overcome the limitations of estimates and manual measurements.}, language = {en} } @article{HaghoferParlakBarteletal.2024, author = {Haghofer, Andreas and Parlak, Eda and Bartel, Alexander and Donovan, Taryn and Assenmacher, Charles-Antoine and Bolfa, Pompei and Dark, Michael and Fuchs-Baumgartinger, Andrea and Klang, Andrea and J{\"a}ger, Kathrin and Klopfleisch, Robert and Merz, Sophie and Richter, Barbara and Schulman, F. Yvonne and Janout, Hannah and Ganz, Jonathan and Scharinger, Josef and Aubreville, Marc and Winkler, Stephan M. and Kiupel, Matti and Bertram, Christof}, title = {Nuclear pleomorphism in canine cutaneous mast cell tumors: Comparison of reproducibility and prognostic relevance between estimates, manual morphometry, and algorithmic morphometry}, volume = {62}, journal = {Veterinary Pathology}, number = {2}, publisher = {Sage}, address = {London}, issn = {1544-2217}, doi = {https://doi.org/10.1177/03009858241295399}, pages = {161 -- 177}, year = {2024}, abstract = {Variation in nuclear size and shape is an important criterion of malignancy for many tumor types; however, categorical estimates by pathologists have poor reproducibility. Measurements of nuclear characteristics can improve reproducibility, but current manual methods are time-consuming. The aim of this study was to explore the limitations of estimates and develop alternative morphometric solutions for canine cutaneous mast cell tumors (ccMCTs). We assessed the following nuclear evaluation methods for accuracy, reproducibility, and prognostic utility: (1) anisokaryosis estimates by 11 pathologists; (2) gold standard manual morphometry of at least 100 nuclei; (3) practicable manual morphometry with stratified sampling of 12 nuclei by 9 pathologists; and (4) automated morphometry using deep learning-based segmentation. The study included 96 ccMCTs with available outcome information. Inter-rater reproducibility of anisokaryosis estimates was low (k = 0.226), whereas it was good (intraclass correlation = 0.654) for practicable morphometry of the standard deviation (SD) of nuclear size. As compared with gold standard manual morphometry (area under the ROC curve [AUC] = 0.839, 95\% confidence interval [CI] = 0.701-0.977), the prognostic value (tumor-specific survival) of SDs of nuclear area for practicable manual morphometry and automated morphometry were high with an AUC of 0.868 (95\% CI = 0.737-0.991) and 0.943 (95\% CI = 0.889-0.996), respectively. This study supports the use of manual morphometry with stratified sampling of 12 nuclei and algorithmic morphometry to overcome the poor reproducibility of estimates. Further studies are needed to validate our findings, determine inter-algorithmic reproducibility and algorithmic robustness, and explore tumor heterogeneity of nuclear features in entire tumor sections.}, language = {en} }