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Survey about do-it-yourself closed loop systems in the treatment of diabetes in Germany

  • Continuous glucose monitoring (CGM) improves treatment with lower blood glucose levels and less patient effort. In combination with continuous insulin application, glycemic control improves and hypoglycemic episodes should decrease. Direct feedback of CGM to continuous subcutaneous insulin application, using an algorithm is called a closed-loop (CL) artificial pancreas system. Commercial devices stop insulin application by predicting hypoglycemic blood glucose levels through direct interaction between the sensor and pump. The prediction is usually made for about 30 minutes and insulin delivery is restarted at the previous level if a rise in blood glucose is predicted within the next 30 minutes (hybrid closed loop system, HCL this is known as a predictive low glucose suspend system (PLGS)). In a fully CL system, sensor and pump communicate permanently with each other. Hybrid closedloop (HCL) systems, which require the user to estimate the meal size and provide a meal insulin basis, are commercially available in Germany at the moment. These systems result in fewer hyperglycemic and hypoglycemic episodes with improved glucose control. Open source initiatives have provided support by building do-it-yourself CL (DIYCL) devices for automated insulin application since 2014, and are used by a tech-savvy subgroup of patients. The first commercial hybrid CL system has been available in Germany since September 2019. We surveyed 1054 patients to determine which devices are currently used, which features would be in demand by potential users, and the benefits of DIYCL systems. 9.7% of these used a DIYCL system, while 50% would most likely trust these systems but more than 85% of the patients would use a commercial closed loop system, if available. The DIYCL users had a better glucose control regarding their time in range (TIR) and glycated hemoglobin (HbA1c).

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Metadaten
Author:Anna Laura Herzog, Jonas Busch, Christoph Wanner, Holger K. von Jouanne-Diedrich
URL:https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0243465
DOI:https://doi.org/https://doi.org/10.1371/journal. pone.0243465
Parent Title (English):Plos one
Editor:Maria Carmen Iglesias-Osma
Document Type:Article
Language:English
Year of Completion:2020
Date of first Publication:2020/12/17
Release Date:2021/07/05
GND Keyword:Kontinuierliches Glucosemonitoring
Volume:2020
Issue:Online/2020
First Page:1
Last Page:17
Urheberrecht:1
research focus :Wissensmanagement und Strukturwandel / Business Transformation and Innovation Management
Licence (German):Keine Lizenz - es gilt das deutsche Urheberrecht
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