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Characterization of electrically conductive, printable ink based on alginate hydrogel and graphene nanoplatelets

  • In recent years, there has been an increasing interest in electrically conductive hydrogels for a wide range of biomedical applications, like tissue engineering or biosensors. In this study, we present a cost-effective conductive hydrogel based on alginate and graphene nanoplatelets for extrusion-based bioprinters. The hydrogel is prepared under ambient conditions avoiding high temperatures detrimental for cell culture environments. Investigation of the hydrogel revealed a conductivity of up to 7.5 S/cm, depending on the ratio of platelets. Furthermore, in vitro tests with human embyronic kidney cells - as an example cell type - showed good adhesion of the cells to the surface of the conductive hydrogel. Electrochemical measurements revealed a low electrode impedance which is desirable for the extracellular recording, but also low electrode capacitance, which is unfavorable for electrical stimulation purposes. Therefore, future experiments with the graphene nanoplatelets-based hydrogels will focus on electrodes for biosensors and extracellular recordings of neurons or cardiac myocytes.

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Author:Dennis Flachs, Johannes Etzel, Margot Mayer, Frederic Harbecke, Stefan Belle, Tim Rickmeyer, Christiane Thielemann
DOI:https://doi.org/https://doi.org/10.1016/j.bea.2022.100045
Parent Title (English):Biomedical Engineering Advances
Document Type:Article
Language:English
Year of Completion:2022
Release Date:2022/11/22
GND Keyword:Hydrogel; Biosensor; Alginate
Volume:2022
Issue:4
First Page:1
Last Page:2
Urheberrecht:0
Institutes:Fakultät Ingenieurwissenschaften / Labore / BIOMEMS Lab
research focus :Materials / Innovative Material Processing
Licence (German):Creative Commons - CC BY - Namensnennung 4.0 International
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