• search hit 2 of 23
Back to Result List

Ultrathin gold as sensor platform for biomolecules

  • Due to the increasing number of diabetes patients worldwide there is an enormous need for accurate, fast and someday also continuous or even closed loop monitoring of blood glucose level. More than 50 years after Clark and Lyons proposed the first glucose enzyme electrodes this concept is still widely in use today. Most concepts use the enzyme glucose oxidase (GOx) that reacts with glucose. These reactions cause a current that is proportional to the amount of glucose present at the sensor. Thus, if the sample volume is known, the blood sugar level can be measured. Although these electrodes have been in use for so long they have the disadvantage of a limited shelf time. In this work we present an enzyme free approach for glucose detection applying ultrathin gold films. According to the basic Fuchs-Sondheimer-theory and other more sophisticated models the resistivity of ultrathin metal films is dominated by scattering effects at their surface. Chemical reactions at the metallic surface are expected to change the conductivity properties and thus these changes can be used to detect molecules. This can be done by creating a self-assembled monolayer at the gold surface. When molecules such as glucose bind to the end groups of this layer the electron scattering and thus the conductivity of the film is expected to change. Ultrathin gold films with a thickness of 6 nm show the largest relative change in resistivity and are thus the preferred film thickness for this application. These gold films show a significant change in resistance when model molecules sodium sulfide and dextran are present, whereas the resistance of a platinum reference electrode does not change significantly.

Export metadata

Additional Services

Search Google Scholar
Metadaten
Author:Christoph Nick, Christina Hock, Florian Emmerich, Stefan Belle, Christiane Thielemann, Tim Asmus, Thomas Loose, Karlheinz Wienand
DOI:https://doi.org/10.1109/3M-NANO.2015.7425462
Parent Title (English):2015 International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO), Changchun, China
Document Type:Conference Proceeding
Language:English
Year of Completion:2015
Release Date:2020/04/29
Tag:biosensor; enzyme free glucose sensor; glucose; ultrathin gold
GND Keyword:Biosensor; Dünne Schicht; Gold
Urheberrecht:0
research focus :Intelligent Systems / Artifical Intelligence and Data Science
Intelligent Systems / Clean Tech
Intelligent Systems / Intelligent Sensors and Signals
Materials / Material Testing & Sensor Technology
Licence (German):Keine Lizenz - es gilt das deutsche Urheberrecht
Einverstanden ✔
Diese Webseite verwendet technisch erforderliche Session-Cookies. Durch die weitere Nutzung der Webseite stimmen Sie diesem zu. Unsere Datenschutzerklärung finden Sie hier.