Spatial-Temporal Genome Regulation in Stress-Response and Cell-Fate Change

  • Complex functioning of the genome in the cell nucleus is controlled at different levels: (a) the DNA base sequence containing all relevant inherited information; (b) epigenetic pathways consisting of protein interactions and feedback loops; (c) the genome architecture and organization activating or suppressing genetic interactions between different parts of the genome. Most research so far has shed light on the puzzle pieces at these levels. This article, however, attempts an integrative approach to genome expression regulation incorporating these different layers. Under environmental stress or during cell development, differentiation towards specialized cell types, or to dysfunctional tumor, the cell nucleus seems to react as a whole through coordinated changes at all levels of control. This implies the need for a framework in which biological, chemical, and physical manifestations can serve as a basis for a coherent theory of gene self-organization. An international symposium held at the Biomedical Research and Study Center in Riga, Latvia, on 25 July 2022 addressed novel aspects of the abovementioned topic. The present article reviews the most recent results and conclusions of the state-of-the-art research in this multidisciplinary field of science, which were delivered and discussed by scholars at the Riga symposium.

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Author:Jekaterina ErenpreisaORCiD, Alessandro GiulianiORCiD, Kenichi YoshikawaORCiD, Martin FalkORCiD, Georg HildenbrandORCiD, Kristine Salmina, Talivaldis Freivalds, Ninel Vainshelbaum, Jonas Weidner, Aaron Sievers, Götz Pilarczyk, Michael HausmannORCiD
DOI:https://doi.org/https://doi.org/10.3390/ijms24032658
ISSN:1422-0067
Parent Title (English):International Journal of Molecular Sciences
Publisher:MDPI AG
Document Type:Article
Language:English
Year of Completion:2023
Release Date:2024/11/14
GND Keyword:Zellkern; Genom
Volume:24
Issue:3
Article Number:2658
Institutes:Fakultät Ingenieurwissenschaften und Informatik / Studiengänge / Medical Engineering and Data Science (Bachelor)
Research Focuses / Research Horizons:Intelligent Systems / Artifical Intelligence and Data Science
Materials / Material Testing & Sensor Technology
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