Multiclass classification of Autism Spectrum Disorder, attention deficit hyperactivity disorder, and typically developed individuals using fMRI functional connectivity analysis
- Neurodevelopmental conditions, such as Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Disorder (ADHD), present unique challenges due to overlapping symptoms, making an accurate diagnosis and targeted intervention difficult. Our study employs advanced machine learning techniques to analyze functional magnetic resonance imaging (fMRI) data from individuals with ASD, ADHD, and typically developed (TD) controls, totaling 120 subjects in the study. Leveraging multiclass classification (ML) algorithms, we achieve superior accuracy in distinguishing between ASD, ADHD, and TD groups, surpassing existing benchmarks with an area under the ROC curve near 98%. Our analysis reveals distinct neural signatures associated with ASD and ADHD: individuals with ADHD exhibit altered connectivity patterns of regions involved in attention and impulse control, whereas those with ASD show disruptions in brain regions critical for social and cognitive functions. The observed connectivity patterns, on which the ML c
| Author: | Caroline L. Alves, Francisco A. Rodrigues, Loriz Francisco Sallum, Thaise Toutain, Joel Porto, Patricia Aguiar, Christiane ThielemannORCiD, Michael Möckel |
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| URL: | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0305630 |
| DOI: | https://doi.org/https://doi.org/10.1371/journal.pone.0305630 |
| Parent Title (English): | plos one |
| Document Type: | Article |
| Language: | English |
| Year of Completion: | 2024 |
| Date of first Publication: | 2024/10/17 |
| Release Date: | 2024/10/21 |
| GND Keyword: | Aufmerksamkeitsdefizit-Syndrom; Autismus; Funktionelle Kernspintomografie |
| Volume: | 2024 |
| Issue: | 19(10) |
| First Page: | 1 |
| Last Page: | 35 |
| Urheberrecht: | 1 |
| Institutes: | Fakultät Ingenieurwissenschaften und Informatik / Labore / BIOMEMS Lab |
| research focus : | Intelligent Systems / Artifical Intelligence and Data Science |
| Reviewed: | ja |
| Licence (German): | Creative Commons - CC BY - Namensnennung 4.0 International |

